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protein coding gene - rrn7 (SPBC336.09c) - RNA polymerase I and II general transcription initiation factor subunit Rrn7

Gene summary

Standard name
rrn7
Systematic ID
SPBC336.09c
Product
RNA polymerase I and II general transcription initiation factor subunit Rrn7
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9UST5
ORFeome ID
35/35B03
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 2756276..2758283 reverse strand

Annotation

GO biological process

GO:0042790 - nucleolar large rRNA transcription by RNA polymerase I

References:

GO:0060963 - positive regulation of ribosomal protein gene transcription by RNA polymerase II

References:

GO:0001188 - RNA polymerase I preinitiation complex assembly

References:

GO:0006361 - transcription initiation at RNA polymerase I promoter

References:

GO:0006367 - transcription initiation at RNA polymerase II promoter

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GO cellular component

GO:0005829 - cytosol

References:

GO:0005634 - nucleus

References:

GO:0070860 - RNA polymerase I core factor complex

References:

GO:0000120 - RNA polymerase I transcription regulator complex

References:

GO molecular function

GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific

References:

GO:0001164 - RNA polymerase I core promoter sequence-specific DNA binding

References:

GO:0001181 - RNA polymerase I general transcription initiation factor activity

References:

GO:0000979 - RNA polymerase II core promoter sequence-specific DNA binding

References:

Modification

MOD:00046 - O-phospho-L-serine

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MOD:00047 - O-phospho-L-threonine

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000059 - abnormal mitotic cell cycle

References:

Genotypes:

FYPO:0001838 - decreased protein phosphorylation during vegetative growth

References:

Genotypes:

FYPO:0000780 - increased transcription during vegetative growth

References:

Genotypes:

FYPO:0001490 - inviable elongated vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0001511 - inviable vegetative cell, abnormal cell shape, normal cell size

References:

Genotypes:

FYPO:0000655 - normal DNA binding

References:

Genotypes:

FYPO:0001855 - normal transcription during vegetative growth

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF11781Zn_ribbon_RRN7TF_Rrn7_ZfPfam
PF20644Rrn7_cyclin_NRrn7_cyclin_NPfam
PF20645Rrn7_cyclin_CRrn7_cyclin_CPfam
PTHR31576TAF1B/Rrn7PANTHER
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder

Orthologs

References / Literature

PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.
Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7
PMID:28060464 - RNA polymerase II components and Rrn7 form a preinitiation complex on the HomolD box to promote ribosomal protein gene expression in Schizosaccharomyces pombe.
Montes M et al. FEBS J 2017 Feb;284(4):615-633
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:25410910 - Casein kinase 2 inhibits HomolD-directed transcription by Rrn7 in Schizosaccharomyces pombe.
Moreira-Ramos S et al. FEBS J 2015 Feb;282(3):491-503
PANTHER:PTHR31576 - Unknown title
PMID:27902423 - Characterization of cis -elements in the promoter of trz2 encoding Schizosaccharomyces pombe mitochondrial tRNA 3'-end processing enzyme.
Liu J et al. Microbiology (Reading) 2017 Jan;163(1):75-85
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:12095692 - Characterization of a fission yeast subunit of an RNA polymerase I essential transcription initiation factor, SpRrn7h/TAF(I)68, that bridges yeast and mammals: association with SpRrn11h and the core ribosomal RNA gene promoter.
Boukhgalter B et al. Gene 2002 May 29;291(1-2):187-201
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6