protein coding gene - cdc10 (SPBC336.12c) - DNA-binding transcription factor, MBF transcription factor complex subunit Cdc10

Gene summary

Standard name

cdc10

Systematic ID

SPBC336.12c

Product

DNA-binding transcription factor, MBF transcription factor complex subunit Cdc10

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

P01129

ORFeome ID

33/33G05

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 2760741..2763800 reverse strand

Annotation

Protein features

Orthologs

• cdc10 (SJAG_02810) Schizosaccharomyces japonicus
• SWI6 (YLR182W) Saccharomyces cerevisiae

References / Literature

PMID:9870697 - Differential effects of caffeine on DNA damage and replication cell cycle checkpoints in the fission yeast Schizosaccharomyces pombe.

Osman F et al. Mol Gen Genet 1998 Nov;260(4):319-34

PMID:9430640 - Regulation of the G1 phase of the cell cycle by periodic stabilization and degradation of the p25rum1 CDK inhibitor.

Benito J et al. EMBO J 1998 Jan 15;17(2):482-97

PMID:7926774 - pct1+, which encodes a new DNA-binding partner of p85cdc10, is required for meiosis in the fission yeast Schizosaccharomyces pombe.

Zhu Y et al. Genes Dev 1994 Apr 15;8(8):885-98

PMID:8838655 - Fission yeast Nda1 and Nda4, MCM homologs required for DNA replication, are constitutive nuclear proteins.

Okishio N et al. J Cell Sci 1996 Feb;109 ( Pt 2):319-26

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:11795845 - The role of DSC1 components cdc10+, rep1+ and rep2+ in MCB gene transcription at the mitotic G1-S boundary in fission yeast.

White S et al. Curr Genet 2001 Dec;40(4):251-9

PMID:29813053 - Specific detection of fission yeast primary septum reveals septum and cleavage furrow ingression during early anaphase independent of mitosis completion.

G Cortés JC et al. PLoS Genet 2018 May;14(5):e1007388

PMID:15128870 - A role for the Cdc14-family phosphatase Flp1p at the end of the cell cycle in controlling the rapid degradation of the mitotic inducer Cdc25p in fission yeast.

Esteban V et al. J Cell Sci 2004 May 15;117(Pt 12):2461-8

PMID:7916658 - The fission yeast cdc18+ gene product couples S phase to START and mitosis.

Kelly TJ et al. Cell 1993 Jul 30;74(2):371-82

PMID:7588609 - Fission yeast Rep2 is a putative transcriptional activator subunit for the cell cycle 'start' function of Res2-Cdc10.

Nakashima N et al. EMBO J 1995 Oct 02;14(19):4794-802

PMID:9203579 - The Spg1p GTPase is an essential, dosage-dependent inducer of septum formation in Schizosaccharomyces pombe.

Schmidt S et al. Genes Dev 1997 Jun 15;11(12):1519-34

PMID:11084332 - Cut8, essential for anaphase, controls localization of 26S proteasome, facilitating destruction of cyclin and Cut2.

Tatebe H et al. Curr Biol 2000 Nov 02;10(21):1329-38

PMID:21118960 - The fission yeast rDNA-binding protein Reb1 regulates G1 phase under nutritional stress.

Rodríguez-Sánchez L et al. J Cell Sci 2011 Jan 01;124(Pt 1):25-34

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:23695302 - Functional characterization of fission yeast transcription factors by overexpression analysis.

Vachon L et al. Genetics 2013 Aug;194(4):873-84

PMID:15827087 - End4/Sla2 is involved in establishment of a new growth zone in Schizosaccharomyces pombe.

Castagnetti S et al. J Cell Sci 2005 May 01;118(Pt 9):1843-50

PMID:8087848 - Temporal order of S phase and mitosis in fission yeast is determined by the state of the p34cdc2-mitotic B cyclin complex.

Hayles J et al. Cell 1994 Sep 09;78(5):813-22

PMID:7883794 - Regulation of the cell cycle timing of Start in fission yeast by the rum1+ gene.

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PMID:8632802 - Cut2 proteolysis required for sister-chromatid seperation in fission yeast.

Funabiki H et al. Nature 1996 May 30;381(6581):438-41

PMID:9118941 - Functional characterization of the fission yeast Start-specific transcription factor Res2.

Zhu Y et al. EMBO J 1997 Mar 03;16(5):1023-34

PMID:30824696 - Systematic analysis reveals the prevalence and principles of bypassable gene essentiality.

Li J et al. Nat Commun 2019 Mar 01;10(1):1002

PMID:8313888 - cdt1 is an essential target of the Cdc10/Sct1 transcription factor: requirement for DNA replication and inhibition of mitosis.

Hofmann JF et al. EMBO J 1994 Jan 15;13(2):425-34

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:18662996 - The DNA replication checkpoint directly regulates MBF-dependent G1/S transcription.

Dutta C et al. Mol Cell Biol 2008 Oct;28(19):5977-85

PMID:19750219 - The role of specific checkpoint-induced S-phase transcripts in resistance to replicative stress.

Dutta C et al. PLoS One 2009 Sep 11;4(9):e6944

PMID:9200612 - tea1 and the microtubular cytoskeleton are important for generating global spatial order within the fission yeast cell.

Mata J et al. Cell 1997 Jun 13;89(6):939-49

PMID:16096637 - Fission yeast MO25 protein is localized at SPB and septum and is essential for cell morphogenesis.

Kanai M et al. EMBO J 2005 Sep 07;24(17):3012-25

PMID:10490657 - Association of fission yeast Orp1 and Mcm6 proteins with chromosomal replication origins.

Ogawa Y et al. Mol Cell Biol 1999 Oct;19(10):7228-36

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:2894685 - Control over the onset of DNA synthesis in fission yeast.

Simanis V et al. Philos Trans R Soc Lond B Biol Sci 1987 Dec 15;317(1187):507-16

PMID:6943408 - Cell division cycle mutants altered in DNA replication and mitosis in the fission yeast Schizosaccharomyces pombe.

Nasmyth K et al. Mol Gen Genet 1981;182(1):119-24

PMID:10779336 - Fission yeast Eso1p is required for establishing sister chromatid cohesion during S phase.

Tanaka K et al. Mol Cell Biol 2000 May;20(10):3459-69

PMID:26201080 - The DNA-Binding Domain of S. pombe Mrc1 (Claspin) Acts to Enhance Stalling at Replication Barriers.

Zech J et al. PLoS One 2015;10(7):e0132595

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:9108295 - The Schizosaccharomyces pombe cdc6 gene encodes the catalytic subunit of DNA polymerase delta.

Iino Y et al. Mol Gen Genet 1997 Mar 18;254(1):93-7

PMID:9303312 - Control of S-phase periodic transcription in the fission yeast mitotic cycle.

Baum B et al. EMBO J 1997 Aug 01;16(15):4676-88

PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.

Mata J et al. Nat Genet 2002 Sep;32(1):143-7

PMID:14648198 - DSC1-MCB regulation of meiotic transcription in Schizosaccharomyces pombe.

Cunliffe L et al. Mol Genet Genomics 2004 Feb;271(1):60-71

PMID:16816948 - Pol5p, a novel binding partner to Cdc10p in fission yeast involved in rRNA production.

Nadeem FK et al. Mol Genet Genomics 2006 Oct;276(4):391-401

PMID:2406029 - Mutation of fission yeast cell cycle control genes abolishes dependence of mitosis on DNA replication.

Enoch T et al. Cell 1990 Feb 23;60(4):665-73

PMID:8223442 - The activity of S.pombe DSC-1-like factor is cell cycle regulated and dependent on the activity of p34cdc2.

Reymond A et al. EMBO J 1993 Nov;12(11):4325-34

PMID:9405296 - Genes that cause aberrant cell morphology by overexpression in fission yeast: a role of a small GTP-binding protein Rho2 in cell morphogenesis.

Hirata D et al. J Cell Sci 1998 Jan;111 ( Pt 2):149-59

PMID:1934126 - Common genes and pathways in the regulation of the mitotic and meiotic cell cycles of Schizosaccharomyces pombe.

Grallert B et al. Curr Genet 1991 Aug;20(3):199-204

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134

PMID:12411492 - Plo1(+) regulates gene transcription at the M-G(1) interval during the fission yeast mitotic cell cycle.

Anderson M et al. EMBO J 2002 Nov 01;21(21):5745-55

PMID:26912660 - Gad8 Protein Is Found in the Nucleus Where It Interacts with the MluI Cell Cycle Box-binding Factor (MBF) Transcriptional Complex to Regulate the Response to DNA Replication Stress.

Cohen A et al. J Biol Chem 2016 Apr 22;291(17):9371-81

PMID:17936710 - Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination.

Limbo O et al. Mol Cell 2007 Oct 12;28(1):134-46

PMID:20501954 - Search for kinases related to transition of growth polarity in fission yeast.

Koyano T et al. Biosci Biotechnol Biochem 2010;74(5):1129-33

PMID:7593289 - Interaction of cdc2 and rum1 regulates Start and S-phase in fission yeast.

Labib K et al. J Cell Sci 1995 Oct;108 ( Pt 10):3285-94

PMID:8121488 - Regulation of progression through the G1 phase of the cell cycle by the rum1+ gene.

Moreno S et al. Nature 1994 Jan 20;367(6460):236-42

PMID:19714215 - The fission yeast homeodomain protein Yox1p binds to MBF and confines MBF-dependent cell-cycle transcription to G1-S via negative feedback.

Aligianni S et al. PLoS Genet 2009 Aug;5(8):e1000626

PMID:8886983 - The fission yeast sts5+ gene is required for maintenance of growth polarity and functionally interacts with protein kinase C and an osmosensing MAP-kinase pathway.

Toda T et al. J Cell Sci 1996 Sep;109 ( Pt 9):2331-42

PMID:8895572 - The role of proteolysis in cell cycle progression in Schizosaccharomyces pombe.

Yamano H et al. EMBO J 1996 Oct 01;15(19):5268-79

PMID:11513869 - mik1(+) G1-S transcription regulates mitotic entry in fission yeast.

Ng SS et al. FEBS Lett 2001 Aug 17;503(2-3):131-4

PMID:20624220 - Kin1 is a plasma membrane-associated kinase that regulates the cell surface in fission yeast.

Cadou A et al. Mol Microbiol 2010 Sep;77(5):1186-202

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:8521469 - p65cdc18 plays a major role controlling the initiation of DNA replication in fission yeast.

Nishitani H et al. Cell 1995 Nov 03;83(3):397-405

PMID:7739540 - The Schizosaccharomyces pombe MBF complex requires heterodimerization for entry into S phase.

Ayté J et al. Mol Cell Biol 1995 May;15(5):2589-99

PMID:9312055 - Fission yeast Cut2 required for anaphase has two destruction boxes.

Funabiki H et al. EMBO J 1997 Oct 01;16(19):5977-87

PMID:21304269 - A homeodomain transcription factor regulates the DNA replication checkpoint in yeast.

Purtill FS et al. Cell Cycle 2011 Feb 15;10(4):664-70

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:7909513 - A B-type cyclin negatively regulates conjugation via interacting with cell cycle 'start' genes in fission yeast.

Obara-Ishihara T et al. EMBO J 1994 Apr 15;13(8):1863-72

PMID:8292390 - A novel mutation involved in the mitotic checkpoint in the fission yeast Schizosaccharomyces pombe.

Ishiguro J et al. Jpn J Genet 1993 Aug;68(4):265-76

PMID:958201 - Genetic control of the cell division cycle in the fission yeast Schizosaccharomyces pombe.

Nurse P et al. Mol Gen Genet 1976 Jul 23;146(2):167-78

PMID:9693370 - Mutational effect of fission yeast polalpha on cell cycle events.

Bhaumik D et al. Mol Biol Cell 1998 Aug;9(8):2107-23

PMID:9153313 - Isolation and characterization of the Schizosaccharomyces pombe rhp9 gene: a gene required for the DNA damage checkpoint but not the replication checkpoint.

Willson J et al. Nucleic Acids Res 1997 Jun 01;25(11):2138-46

PMID:35320724 - Cdc48 influence on separase levels is independent of mitosis and suggests translational sensitivity of separase.

Vijayakumari D et al. Cell Rep 2022 Mar 22;38(12):110554

PMID:17895368 - Schizosaccharomyces pombe protein phosphatase 1 in mitosis, endocytosis and a partnership with Wsh3/Tea4 to control polarised growth.

Alvarez-Tabarés I et al. J Cell Sci 2007 Oct 15;120(Pt 20):3589-601

PMID:31719112 - Checkpoint Regulation of Nuclear Tos4 Defines S Phase Arrest in Fission Yeast.

Kim SM et al. G3 (Bethesda) 2020 Jan 07;10(1):255-266

PMID:23986474 - Mutation of a conserved residue enhances the sensitivity of analogue-sensitised kinases to generate a novel approach to the study of mitosis in fission yeast.

Tay YD et al. J Cell Sci 2013 Nov 01;126(Pt 21):5052-61

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:8187760 - Genetic analysis of cell morphogenesis in fission yeast--a role for casein kinase II in the establishment of polarized growth.

Snell V et al. EMBO J 1994 May 01;13(9):2066-74

PMID:19109429 - GINS inactivation phenotypes reveal two pathways for chromatin association of replicative alpha and epsilon DNA polymerases in fission yeast.

Pai CC et al. Mol Biol Cell 2009 Feb;20(4):1213-22

PMID:15297457 - On the slowing of S phase in response to DNA damage in fission yeast.

Kumar S et al. J Biol Chem 2004 Oct 15;279(42):43574-80

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:12871901 - The Schizosaccharomyces pombe cdt2(+) gene, a target of G1-S phase-specific transcription factor complex DSC1, is required for mitotic and premeiotic DNA replication.

Yoshida SH et al. Genetics 2003 Jul;164(3):881-93

PMID:24713849 - Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex.

Egan ED et al. RNA 2014 Jun;20(6):867-81

PMID:10559981 - A Rad3-Rad26 complex responds to DNA damage independently of other checkpoint proteins.

Edwards RJ et al. Nat Cell Biol 1999 Nov;1(7):393-8

PMID:8313892 - The Schizosaccharomyces pombe cdc5+ gene encodes an essential protein with homology to c-Myb.

Ohi R et al. EMBO J 1994 Jan 15;13(2):471-83

PMID:17112379 - The CENP-B homolog, Abp1, interacts with the initiation protein Cdc23 (MCM10) and is required for efficient DNA replication in fission yeast.

Locovei AM et al. Cell Div 2006 Nov 17;1:27

PMID:1522142 - Cytoskeletal and DNA structure abnormalities result from bypass of requirement for the cdc10 start gene in the fission yeast Schizosaccharomyces pombe.

Marks J et al. J Cell Sci 1992 Mar;101 ( Pt 3):517-28

PMID:9092625 - Characterisation of Schizosaccharomyces pombe rad31, a UBA-related gene required for DNA damage tolerance.

Shayeghi M et al. Nucleic Acids Res 1997 Mar 15;25(6):1162-9

PMID:9392077 - Measurement of nuclear DNA content in fission yeast by flow cytometry.

Carlson CR et al. Yeast 1997 Nov;13(14):1329-35

PMID:10574765 - Mis-specification of cortical identity in a fission yeast PAK mutant.

Sawin KE et al. Curr Biol 1999 Nov 18;9(22):1335-8

PMID:15302827 - The forkhead transcription factor Fkh2 regulates the cell division cycle of Schizosaccharomyces pombe.

Bulmer R et al. Eukaryot Cell 2004 Aug;3(4):944-54

PMID:9928931 - The S/M checkpoint at 37 degrees C and the recovery of viability of the mutant poldeltats3 require the crb2+/rhp9+ gene in fission yeast.

Grenon M et al. Mol Gen Genet 1999 Jan;260(6):522-34

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:21132016 - Yox1 links MBF-dependent transcription to completion of DNA synthesis.

Gómez-Escoda B et al. EMBO Rep 2011 Jan;12(1):84-9

PMID:1734281 - Control of DNA synthesis genes in fission yeast by the cell-cycle gene cdc10+.

Lowndes NF et al. Nature 1992 Jan 30;355(6359):449-53

PMID:11854409 - The multiprotein exocyst complex is essential for cell separation in Schizosaccharomyces pombe.

Wang H et al. Mol Biol Cell 2002 Feb;13(2):515-29

PMID:31719163 - A novel interplay between GEFs orchestrates Cdc42 activity during cell polarity and cytokinesis in fission yeast.

Hercyk BS et al. J Cell Sci 2019 Dec 03;132(23)

PMID:12898217 - MCB-mediated regulation of cell cycle-specific cdc22+ transcription in fission yeast.

Maqbool Z et al. Mol Genet Genomics 2003 Sep;269(6):765-75

PMID:7957098 - Fission yeast cut5 links nuclear chromatin and M phase regulator in the replication checkpoint control.

Saka Y et al. EMBO J 1994 Nov 15;13(22):5319-29

PMID:9472012 - The Cdk inhibitors p25rum1 and p40SIC1 are functional homologues that play similar roles in the regulation of the cell cycle in fission and budding yeast.

Sánchez-Díaz A et al. J Cell Sci 1998 Mar;111 ( Pt 6):843-51

PMID:12972571 - Fission yeast Cdc23/Mcm10 functions after pre-replicative complex formation to promote Cdc45 chromatin binding.

Gregan J et al. Mol Biol Cell 2003 Sep;14(9):3876-87

PMID:8799851 - The kinetics of the B cyclin p56cdc13 and the phosphatase p80cdc25 during the cell cycle of the fission yeast Schizosaccharomyces pombe.

Creanor J et al. J Cell Sci 1996 Jun;109 ( Pt 6):1647-53

PMID:9490640 - A NIMA homologue promotes chromatin condensation in fission yeast.

Krien MJ et al. J Cell Sci 1998 Apr;111 ( Pt 7):967-76

PMID:8168485 - res2+, a new member of the cdc10+/SWI4 family, controls the 'start' of mitotic and meiotic cycles in fission yeast.

Miyamoto M et al. EMBO J 1994 Apr 15;13(8):1873-80

PMID:24006488 - The DNA damage and the DNA replication checkpoints converge at the MBF transcription factor.

Ivanova T et al. Mol Biol Cell 2013 Nov;24(21):3350-7

PMID:7796804 - A pre-start checkpoint preventing mitosis in fission yeast acts independently of p34cdc2 tyrosine phosphorylation.

Hayles J et al. EMBO J 1995 Jun 15;14(12):2760-71

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:11683390 - In vivo localisation of fission yeast cyclin-dependent kinase cdc2p and cyclin B cdc13p during mitosis and meiosis.

Decottignies A et al. J Cell Sci 2001 Jul;114(Pt 14):2627-40

PMID:8521500 - p25rum1 orders S phase and mitosis by acting as an inhibitor of the p34cdc2 mitotic kinase.

Correa-Bordes J et al. Cell 1995 Dec 15;83(6):1001-9

PMID:9034336 - Fission yeast pheromone blocks S-phase by inhibiting the G1 cyclin B-p34cdc2 kinase.

Stern B et al. EMBO J 1997 Feb 03;16(3):534-44

PMID:9303310 - p25rum1 promotes proteolysis of the mitotic B-cyclin p56cdc13 during G1 of the fission yeast cell cycle.

Correa-Bordes J et al. EMBO J 1997 Aug 01;16(15):4657-64

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:27984725 - CDK Substrate Phosphorylation and Ordering the Cell Cycle.

Swaffer MP et al. Cell 2016 Dec 15;167(7):1750-1761.e16

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

PMID:7916653 - Sct1 functions in partnership with Cdc10 in a transcription complex that activates cell cycle START and inhibits differentiation.

Caligiuri M et al. Cell 1993 Feb 26;72(4):607-19

PMID:30134042 - The INO80 complex activates the transcription of S-phase genes in a cell cycle-regulated manner.

Knezevic I et al. FEBS J 2018 Oct;285(20):3870-3881

PMID:9614176 - Cyclin B proteolysis and the cyclin-dependent kinase inhibitor rum1p are required for pheromone-induced G1 arrest in fission yeast.

Stern B et al. Mol Biol Cell 1998 Jun;9(6):1309-21

PMID:16916637 - Constraining G1-specific transcription to late G1 phase: the MBF-associated corepressor Nrm1 acts via negative feedback.

de Bruin RA et al. Mol Cell 2006 Aug;23(4):483-96

PMID:18257517 - Phosphoproteome analysis of fission yeast.

Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97

PMID:1464317 - A new cdc gene required for S phase entry of Schizosaccharomyces pombe encodes a protein similar to the cdc 10+ and SWI4 gene products.

Tanaka K et al. EMBO J 1992 Dec;11(13):4923-32

PMID:9679144 - Regulation of cell polarity by microtubules in fission yeast.

Sawin KE et al. J Cell Biol 1998 Jul 27;142(2):457-71

PMID:12925774 - Schizosacchromyces pombe Dpb2 binds to origin DNA early in S phase and is required for chromosomal DNA replication.

Feng W et al. Mol Biol Cell 2003 Aug;14(8):3427-36

PMID:12186947 - A novel chk1-dependent G1/M checkpoint in fission yeast.

Synnes M et al. J Cell Sci 2002 Sep 15;115(Pt 18):3609-18

PMID:23297348 - Comprehensive proteomics analysis reveals new substrates and regulators of the fission yeast clp1/cdc14 phosphatase.

Chen JS et al. Mol Cell Proteomics 2013 May;12(5):1074-86

PMID:2777915 - Characterization of the fission yeast cdc10+ protein that is required for commitment to the cell cycle.

Simanis V et al. J Cell Sci 1989 Jan;92 ( Pt 1):51-6

PMID:9755169 - Cdc18 transcription and proteolysis couple S phase to passage through mitosis.

Baum B et al. EMBO J 1998 Oct 01;17(19):5689-98

PMID:11027263 - Schizosaccharomyces pombe Hsk1p is a potential cds1p target required for genome integrity.

Snaith HA et al. Mol Cell Biol 2000 Nov;20(21):7922-32

PMID:26205977 - Highly condensed chromatins are formed adjacent to subtelomeric and decondensed silent chromatin in fission yeast.

Matsuda A et al. Nat Commun 2015 Jul 24;6:7753

PMID:3870979 - ran1+ controls the transition from mitotic division to meiosis in fission yeast.

Beach D et al. Curr Genet 1985;10(4):297-311

PMID:36045206 - Cell Cycle Synchrony Methods for Fission Yeast, Schizosaccharomyces pombe.

Kianfard Z et al. Methods Mol Biol 2022;2579:169-179

PMID:9573052 - Pom1p, a fission yeast protein kinase that provides positional information for both polarized growth and cytokinesis.

Bähler J et al. Genes Dev 1998 May 01;12(9):1356-70

PMID:11389847 - Transcriptional termination factors for RNA polymerase II in yeast.

Aranda A et al. Mol Cell 2001 May;7(5):1003-11

PMID:11739790 - Two related kinesins, klp5+ and klp6+, foster microtubule disassembly and are required for meiosis in fission yeast.

West RR et al. Mol Biol Cell 2001 Dec;12(12):3919-32

PMID:8168486 - A zinc finger protein controls the onset of premeiotic DNA synthesis of fission yeast in a Mei2-independent cascade.

Sugiyama A et al. EMBO J 1994 Apr 15;13(8):1881-7

PMID:8657126 - Cig2, a B-type cyclin, promotes the onset of S in Schizosaccharomyces pombe.

Mondesert O et al. Mol Cell Biol 1996 Apr;16(4):1527-33

PMID:11781565 - Feedback regulation of the MBF transcription factor by cyclin Cig2.

Ayté J et al. Nat Cell Biol 2001 Dec;3(12):1043-50

PMID:10888871 - Mitotic replication initiation proteins are not required for pre-meiotic S phase.

Forsburg SL et al. Nat Genet 2000 Jul;25(3):263-8

PMID:10564266 - Cell cycle-regulated transcription in fission yeast: Cdc10-Res protein interactions during the cell cycle and domains required for regulated transcription.

Whitehall S et al. Mol Biol Cell 1999 Nov;10(11):3705-15

PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.

Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85

PMID:1406591 - Mutations in the cdc10 start gene of Schizosaccharomyces pombe implicate the region of homology between cdc10 and SWI6 as important for p85cdc10 function.

Reymond A et al. Mol Gen Genet 1992 Sep;234(3):449-56

PMID:18682565 - DNA replication checkpoint promotes G1-S transcription by inactivating the MBF repressor Nrm1.

de Bruin RA et al. Proc Natl Acad Sci U S A 2008 Aug 12;105(32):11230-5

PMID:17085965 - Function of rax2p in the polarized growth of fission yeast.

Choi E et al. Mol Cells 2006 Oct 31;22(2):146-53

PMID:17998401 - Nuclear size control in fission yeast.

Neumann FR et al. J Cell Biol 2007 Nov 19;179(4):593-600

PMID:19487461 - Cyclin-dependent kinase inhibits reinitiation of a normal S-phase program during G2 in fission yeast.

Kiang L et al. Mol Cell Biol 2009 Aug;29(15):4025-32

PMID:4018034 - Cloning, sequencing and transcriptional control of the Schizosaccharomyces pombe cdc10 'start' gene.

Aves SJ et al. EMBO J 1985 Feb;4(2):457-63

PMID:10388806 - Rereplication phenomenon in fission yeast requires MCM proteins and other S phase genes.

Snaith HA et al. Genetics 1999 Jul;152(3):839-51

PMID:3448096 - Schizosaccharomyces pombe mutants affected in their division response to starvation.

Young PG et al. J Cell Sci 1987 Oct;88 ( Pt 3):295-304

PMID:8631306 - A single fission yeast mitotic cyclin B p34cdc2 kinase promotes both S-phase and mitosis in the absence of G1 cyclins.

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