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protein coding gene - SPBC337.11 - lipid raft associated CH-OH group oxidoreductase, implicated in lipid/sterol metabolism

Gene summary

Systematic ID
SPBC337.11
Product
lipid raft associated CH-OH group oxidoreductase, implicated in lipid/sterol metabolism
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O74822
ORFeome ID
14/14A08
Characterisation status
conserved unknown
Feature type
mRNA gene
Genomic location
chromosome II: 1050041..1051446 forward strand

Annotation

GO molecular function

GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000251 - decreased cell population growth on galactose carbon source

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Genotypes:

FYPO:0009091 - decreased cell population growth on lysine and proline nitrogen source

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Genotypes:

FYPO:0004806 - incomplete cell wall disassembly at cell fusion site

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FYPO:0001309 - increased viability in stationary phase

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FYPO:0000067 - resistance to brefeldin A

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FYPO:0000763 - resistance to cadmium

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FYPO:0002693 - resistance to diamide

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FYPO:0001453 - resistance to ethanol

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FYPO:0001583 - resistance to lithium

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FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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FYPO:0009039 - resistance to potassium chloride

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FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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FYPO:0003383 - resistance to tert-butyl hydroperoxide

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FYPO:0000830 - resistance to vanadate

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FYPO:0001701 - sensitive to bortezomib

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FYPO:0007931 - sensitive to egtazic acid

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FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

Protein features

IDNameInterPro nameDB name
PF00107ADH_zinc_NADH-like_CPfam
PF08240ADH_NADH-like_NPfam
cd05289MDR_like_2CDD
SM00829PKS_ERERSMART
G3DSA:3.90.180.10CATH-Gene3D
SSF50129GroES-like_sfSUPERFAMILY
SSF51735NAD(P)-bd_dom_sfSUPERFAMILY
PTHR43482Lipid_raft_assoc_Zn_ADHPANTHER

Orthologs

References / Literature

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:26098123 - Promoter nucleosome dynamics regulated by signalling through the CTD code.
Materne P et al. Elife 2015 Jun 22;4:e09008
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:29188185 - Metabolic engineering of Schizosaccharomyces pombe via CRISPR-Cas9 genome editing for lactic acid production from glucose and cellobiose.
Ozaki A et al. Metab Eng Commun 2017 Dec;5:60-67
PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.
Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160
GO_REF:0000050 - Manual transfer of GO annotation data to genes by curator judgment of sequence model
PMID:21760946 - Identification of genes affecting the toxicity of anti-cancer drug bortezomib by genome-wide screening in S. pombe.
Takeda K et al. PLoS One 2011;6(7):e22021
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623