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protein coding gene - qrs1 (SPBC342.02) - mitochondrial glutaminyl-tRNA ligase Qrs1

Gene summary

Standard name
qrs1
Systematic ID
SPBC342.02
Product
mitochondrial glutaminyl-tRNA ligase Qrs1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9Y7Y8
ORFeome ID
28/28G04
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 4203334..4205852 forward strand

Annotation

PBO:0004854 - 6.1.1.18

Disease association

MONDO:0014335 - diffuse cerebral and cerebellar atrophy - intractable seizures - progressive microcephaly syndrome

References:

GO biological process

GO:0006425 - glutaminyl-tRNA aminoacylation

References:

GO cellular component

GO:0005829 - cytosol

References:

GO:0005759 - mitochondrial matrix

References:

GO molecular function

GO:0005524 - ATP binding

References:

GO:0004819 - glutamine-tRNA ligase activity

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000311 - inviable after spore germination with normal, unseptated germ tube morphology

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00749tRNA-synt_1cGlu/Gln-tRNA-synth_Ib_cat-domPfam
PF03950tRNA-synt_1c_CGlu/Gln-tRNA-synth_Ib_codon-bdPfam
PF04557tRNA_synt_1c_R2Gln-tRNA-synth_Ib_RNA-bd_2Pfam
PF04558tRNA_synt_1c_R1Gln-tRNA-synth_Ib_RNA-bd_NPfam
PF20974tRNA-synt_1c_C2tRNA-synt_1c_C2Pfam
cd00807GlnRS_coreCDD
PS00178AA_TRNA_LIGASE_Iaa-tRNA-synth_I_CSPROSITE patterns
PR00987TRNASYNTHGLUGlu/Gln-tRNA-synthPRINTS
G3DSA:1.10.10.2420:FF:000001CATH-FunFam
G3DSA:1.10.1160.10:FF:000001CATH-FunFam
G3DSA:1.10.8.1290:FF:000002CATH-FunFam
G3DSA:2.40.240.10:FF:000007CATH-FunFam
G3DSA:2.40.240.10:FF:000015CATH-FunFam
G3DSA:3.40.50.620:FF:000183CATH-FunFam
G3DSA:3.90.800.10:FF:000001CATH-FunFam
G3DSA:1.10.10.2420Gln-tRNA-synth_Ib_RNA-bd_N_2CATH-Gene3D
G3DSA:1.10.8.1290Gln-tRNA-synth_Ib_RNA-bd_N_1CATH-Gene3D
G3DSA:2.40.240.10Rbsml_bL25/Gln-tRNA_synth_NCATH-Gene3D
G3DSA:3.40.50.620Rossmann-like_a/b/a_foldCATH-Gene3D
SSF50715Ribosomal_bL25/Gln-tRNA_synthSUPERFAMILY
SSF52374SUPERFAMILY
PTHR43097Gln/Glu-tRNA_LigasePANTHER
TIGR00440glnSGln-tRNA-synthNCBIFAM
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder
mobidb-lite-Polyampholytedisorder_predictionMobiDB-Polyampholyte
mobidb-lite-Positive-Polyelectrolytedisorder_predictionMobiDB-Positive-Polyelectrolyte

Orthologs

References / Literature

GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.
Lee J et al. Nat Commun 2017 Feb 20;8:14527
PMID:31064814 - Proximity-dependent biotinylation mediated by TurboID to identify protein-protein interaction networks in yeast.
Larochelle M et al. J Cell Sci 2019 May 31;132(11)
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:21386897 - Systematic two-hybrid and comparative proteomic analyses reveal novel yeast pre-mRNA splicing factors connected to Prp19.
Ren L et al. PLoS One 2011 Feb 28;6(2):e16719
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
GO_REF:0000002 - Comments
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:22730331 - Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions.
Nie M et al. J Biol Chem 2012 Aug 24;287(35):29610-9
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7