protein coding gene - sec61 (SPBC354.02c) - Sec61 translocon alpha subunit Sec61

Gene summary

Standard name: sec61
Systematic ID: SPBC354.02c
Product: Sec61 translocon alpha subunit Sec61
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: P79088
ORFeome ID: 26/26E09
Characterisation status: biological role published
Feature type: mRNA gene
Genomic location: chromosome II: 544751..547014 reverse strand

Annotation

Disease association

MONDO:0000608 - familial juvenile hyperuricemic nephropathy

References:

PB_REF:0000003

MONDO:0014891 - hyperuricemic nephropathy, familial juvenile type 4

References:

PB_REF:0000006

MONDO:0958013 - immunodeficiency, common variable, 15

References:

PB_REF:0000006

MONDO:0958017 - neutropenia, severe congenital, 11, autosomal dominant

References:

PB_REF:0000006

GO biological process

GO:0006620 - post-translational protein targeting to endoplasmic reticulum membrane

References:

GO_REF:0000024

GO:0045048 - protein insertion into ER membrane

References:

GO_REF:0000111

GO:0006616 - SRP-dependent cotranslational protein targeting to membrane, translocation

References:

GO_REF:0000033

GO cellular component

GO:0005783 - endoplasmic reticulum

References:

GO:0000324 - fungal-type vacuole

References:

PMID:25803873

GO:0005784 - Sec61 translocon complex

References:

GO_REF:0000024

GO molecular function

GO:0005048 - signal sequence receptor activity

References:

GO_REF:0000033

GO:0008320 - transmembrane protein transporter activity

References:

GO_REF:0000033

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

References:

PMID:39367033

Protein sequence feature

SO:0001812 - transmembrane_helix

References:

PMID:11152613

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PMID:39367033

PomGeneEx:0000012 - RNA level decreased

References:

PMID:27984744

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0000636 - increased cell population growth rate

References:

PMID:25452419

Genotypes:

sec61delta

FYPO:0002151 - inviable spore

References:

PMID:23697806

Genotypes:

sec61delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

sec61delta

Taxonomic conservation

PBO:0011072 - conserved in archaea

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

ID	Name	InterPro name	DB name
PF00344	SecY	SecY/SEC61-alpha	Pfam
PF10559	Plug_translocon	Translocon_Sec61/SecY_plug_dom	Pfam
PS00755	SECY_1	SecY_CS	PROSITE patterns
PS00756	SECY_2	SecY_CS	PROSITE patterns
G3DSA:1.10.3370.10:FF:000009			CATH-FunFam
G3DSA:1.10.3370.10		SecY_dom_sf	CATH-Gene3D
SSF103491		SecY_dom_sf	SUPERFAMILY
PTHR10906		SecY/SEC61-alpha	PANTHER
PIRSF004557	SecY	SecY/SEC61-alpha	PIRSF
NF006341	secY		NCBIFAM
TIGR00967	3a0501s007	SecY/SEC61-alpha	NCBIFAM
Transmembrane alpha helix			DeepTMHMM

Orthologs

SEC61A2 (HGNC:17702) Homo sapiens
SEC61A1 (HGNC:18276) Homo sapiens
sec61 (SJAG_02330) Schizosaccharomyces japonicus
SEC61 (YLR378C) Saccharomyces cerevisiae

References / Literature

PMID:33109728 - High-Throughput Identification of Nuclear Envelope Protein Interactions in Schizosaccharomyces pombe Using an Arrayed Membrane Yeast-Two Hybrid Library.: Varberg JM et al. G3 (Bethesda) 2020 Dec 03;10(12):4649-4663
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.: Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:9427389 - Cloning of SEC61 homologues from Schizosaccharomyces pombe and Yarrowia lipolytica reveals the extent of functional conservation within this core component of the ER translocation machinery.: Broughton J et al. J Cell Sci 1997 Nov;110 ( Pt 21):2715-27
PMID:25452419 - Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.: Sideri T et al. G3 (Bethesda) 2014 Dec 01;5(1):145-55
PMID:12618370 - Schizosaccharomyces pombe essential genes: a pilot study.: Decottignies A et al. Genome Res 2003 Mar;13(3):399-406
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.: Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
PMID:12376568 - An evolutionarily conserved fission yeast protein, Ned1, implicated in normal nuclear morphology and chromosome stability, interacts with Dis3, Pim1/RCC1 and an essential nucleoporin.: Tange Y et al. J Cell Sci 2002 Nov 15;115(Pt 22):4375-85
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:25803873 - Calnexin is essential for survival under nitrogen starvation and stationary phase in Schizosaccharomyces pombe.: Núñez A et al. PLoS One 2015;10(3):e0121059
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.: Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.: Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.: Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PB_REF:0000003 - Disease Association Curation
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.: Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.: Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.: Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7