protein coding gene - mrps16 (SPBC354.06) - mitochondrial ribosomal protein subunit S16

Gene summary

Standard name: mrps16
Systematic ID: SPBC354.06
Product: mitochondrial ribosomal protein subunit S16
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: O43020
ORFeome ID: 43/43A02
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome II: 555825..557248 forward strand

Annotation

Disease association

MONDO:0012510 - combined oxidative phosphorylation defect type 2

References:

PB_REF:0000006

MONDO:0000732 - combined oxidative phosphorylation deficiency

References:

PB_REF:0000003

GO biological process

GO:0032543 - mitochondrial translation

References:

GO_REF:0000024

GO cellular component

GO:0005763 - mitochondrial small ribosomal subunit

References:

GO_REF:0000033

GO molecular function

GO:0003735 - structural constituent of ribosome

References:

GO_REF:0000033

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PMID:39367033

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0002111 - inviable tapered vegetative cell

References:

PMID:23697806

Genotypes:

mrps16delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

mrps16delta

FYPO:0002199 - inviable vegetative cell with normal cell morphology

References:

PMID:23697806

Genotypes:

mrps16delta

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000070 - gene structure updated

References:

PMID:21511999

Protein features

ID	Name	InterPro name	DB name
PF00886	Ribosomal_S16	Ribosomal_bS16	Pfam
G3DSA:3.30.1320.10		Ribosomal_bS16_dom_sf	CATH-Gene3D
SSF54565		Ribosomal_bS16_dom_sf	SUPERFAMILY
PTHR12919		Ribosomal_bS16	PANTHER
TIGR00002	S16	Ribosomal_bS16	NCBIFAM
MF_00385	Ribosomal_bS16	Ribosomal_bS16	HAMAP

Orthologs

MRPS16 (HGNC:14048) Homo sapiens
mrps16 (SJAG_02324) Schizosaccharomyces japonicus
MRPS16 (YPL013C) Saccharomyces cerevisiae

References / Literature

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.: Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PB_REF:0000003 - Disease Association Curation
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36