PomBase - protein coding gene - gpd3 (SPBC354.12) - glyceraldehyde 3-phosphate dehydrogenase Gpd3 - The Schizosaccharomyces pombe genome database

Protein features

ID	Name	InterPro name	DB name
PF02800	Gp_dh_C	GlycerAld_3-P_DH_cat	PFAM
PF00044	Gp_dh_N	GlycerAld_3-P_DH_NAD(P)-bd	PFAM
cd05214	GAPDH_I_N		CDD
cd18126	GAPDH_I_C		CDD
PS00071	GAPDH	GlycerAld_3-P_DH_AS	PROSITE_PATTERNS
SM00846	gp_dh_n_7	GlycerAld_3-P_DH_NAD(P)-bd	SMART
PR00078	G3PDHDRGNASE	GlycerAld/Erythrose_P_DH	PRINTS
G3DSA:3.40.50.720:FF:000266			FUNFAM
G3DSA:3.30.360.10:FF:000001			FUNFAM
SSF51735	NAD(P)-binding Rossmann-fold domains	NAD(P)-bd_dom_sf	SUPERFAMILY
SSF55347	Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain		SUPERFAMILY
G3DSA:3.30.360.10	Dihydrodipicolinate Reductase; domain 2		GENE3D
G3DSA:3.40.50.720			GENE3D
PTHR10836	GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE	GlycerAld/Erythrose_P_DH	PANTHER
PIRSF000149	GAPDH	GlycerAld/Erythrose_P_DH	PIRSF
TIGR01534	GAPDH-I	Glyceraldehyde-3-P_DH_1	NCBIFAM

References / Literature

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.: Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:24957674 - Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.: Anver S et al. EMBO Rep 2014 Aug;15(8):894-902
PMID:21504829 - Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.: Stewart EV et al. Mol Cell 2011 Apr 22;42(2):160-71
PMID:24442611 - Endogenous U2·U5·U6 snRNA complexes in S. pombe are intron lariat spliceosomes.: Chen W et al. RNA 2014 Mar;20(3):308-20
PMID:36174923 - Schizosaccharomyces pombe MAP kinase Sty1 promotes survival of Δppr10 cells with defective mitochondrial protein synthesis.: Hu Y et al. Int J Biochem Cell Biol 2022 Nov;152:106308
PMID:17556368 - The Birt-Hogg-Dube and tuberous sclerosis complex homologs have opposing roles in amino acid homeostasis in Schizosaccharomyces pombe.: van Slegtenhorst M et al. J Biol Chem 2007 Aug 24;282(34):24583-90
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.: Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.: Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.: Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.: Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:31064814 - Proximity-dependent biotinylation mediated by TurboID to identify protein-protein interaction networks in yeast.: Larochelle M et al. J Cell Sci 2019 May 31;132(11)
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:26896847 - Ensembl comparative genomics resources.: Herrero J et al. Database (Oxford) 2016;2016
PMID:24818994 - The S. pombe translation initiation factor eIF4G is Sumoylated and associates with the SUMO protease Ulp2.: Jongjitwimol J et al. PLoS One 2014;9(5):e94182
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.: Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:25117315 - A potential protective role for thiamine in glucose-driven oxidative stress.: Palabiyik B et al. Genet Mol Res 2014 Jul 25;13(3):5582-93
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.: Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.: Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134
PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.: Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41
PMID:18257517 - Phosphoproteome analysis of fission yeast.: Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97
PMID:26890608 - A functional genome-wide genetic screening identifies new pathways controlling the G1/S transcriptional wave.: Gaspa L et al. Cell Cycle 2016;15(5):720-9
PMID:36820394 - Inorganic polyphosphate abets silencing of a sub-telomeric gene cluster in fission yeast.: Sanchez AM et al. MicroPubl Biol 2023;2023
PMID:32282918 - Genetic interactions and transcriptomics implicate fission yeast CTD prolyl isomerase Pin1 as an agent of RNA 3' processing and transcription termination that functions via its effects on CTD phosphatase Ssu72.: Sanchez AM et al. Nucleic Acids Res 2020 May 21;48(9):4811-4826
PMID:18406331 - Glycolytic enzyme GAPDH promotes peroxide stress signaling through multistep phosphorelay to a MAPK cascade.: Morigasaki S et al. Mol Cell 2008 Apr 11;30(1):108-13
PMID:23213482 - TORC2 and the AGC kinase Gad8 regulate phosphorylation of the ribosomal protein S6 in fission yeast.: Du W et al. Biol Open 2012 Sep 15;1(9):884-8
PMID:31276588 - Inositol pyrophosphates impact phosphate homeostasis via modulation of RNA 3' processing and transcription termination.: Sanchez AM et al. Nucleic Acids Res 2019 Sep 19;47(16):8452-8469
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:38133430 - Genetic suppressor screen identifies Tgp1 (glycerophosphocholine transporter), Kcs1 (IP 6 kinase), and Plc1 (phospholipase C) as determinants of inositol pyrophosphate toxicosis in fission yeast.: Bednor L et al. mBio 2023 Dec 22;:e0306223
PMID:23050226 - A genetic screen to discover pathways affecting cohesin function in Schizosaccharomyces pombe identifies chromatin effectors.: Chen Z et al. G3 (Bethesda) 2012 Oct;2(10):1161-8
PMID:30647105 - Comparative Genomic Screen in Two Yeasts Reveals Conserved Pathways in the Response Network to Phenol Stress.: Alhoch B et al. G3 (Bethesda) 2019 Mar 07;9(3):639-650
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:26152728 - A Two-step Protein Quality Control Pathway for a Misfolded DJ-1 Variant in Fission Yeast.: Mathiassen SG et al. J Biol Chem 2015 Aug 21;290(34):21141-21153
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.: Køhler JB et al. Nat Commun 2015 Nov 05;6:8827
PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.: Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85
PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.: Lee J et al. Nat Commun 2017 Feb 20;8:14527
PMID:15620689 - Glyceraldehyde-3-phosphate dehydrogenase and actin associate with RNA polymerase II and interact with its Rpb7 subunit.: Mitsuzawa H et al. FEBS Lett 2005 Jan 03;579(1):48-52
PMID:21652630 - Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.: Snaith HA et al. J Cell Sci 2011 Jul 01;124(Pt 13):2187-99
PMID:22540037 - Predicting the fission yeast protein interaction network.: Pancaldi V et al. G3 (Bethesda) 2012 Apr;2(4):453-67
GO_REF:0000033 - Annotation inferences using phylogenetic trees

protein coding gene - gpd3 (SPBC354.12) - glyceraldehyde 3-phosphate dehydrogenase Gpd3

Gene summary

Annotation

PBO:0003249 - 1.2.1.12

GO biological process

GO:0061621 - canonical glycolysis

GO cellular component

GO:0005829 - cytosol

GO molecular function

GO:0004365 - glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity

Modification

MOD:00046 - O-phospho-L-serine

MOD:00047 - O-phospho-L-threonine

MOD:00696 - phosphorylated residue

MOD:01149 - sumoylated lysine

MOD:01148 - ubiquitinylated lysine

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

PomGeneEx:0000011 - RNA level increased

Quantitative gene expression

PBO:0006310 - protein level

PBO:0011963 - RNA level

Single locus phenotype

FYPO:0000250 - decreased cell population growth on proline nitrogen source

FYPO:0000239 - increased transcription from MCB promoter

FYPO:0000764 - resistance to cycloheximide

FYPO:0009038 - resistance to egtazic acid

FYPO:0001453 - resistance to ethanol

FYPO:0001583 - resistance to lithium

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

FYPO:0006680 - sensitive to bisphenol A

FYPO:0006930 - sensitive to butylated hydroxyanisole

FYPO:0000087 - sensitive to hydrogen peroxide

FYPO:0000089 - sensitive to methyl methanesulfonate

FYPO:0002060 - viable vegetative cell population

FYPO:0002177 - viable vegetative cell with normal cell morphology

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Warnings

PBO:0003248 - merged with ncRNA

Protein features

Orthologs

References / Literature