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protein coding gene - alr2 (SPBC359.02) - alanine racemase Alr2

Gene summary

Standard name
alr2
Systematic ID
SPBC359.02
Product
alanine racemase Alr2
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
alr1
UniProt ID
Q9P5N3
ORFeome ID
17/17E05
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 107759..109353 forward strand

Annotation

GO biological process

GO:0055130 - D-alanine catabolic process

References:

GO cellular component

GO:0005829 - cytosol

References:

GO molecular function

GO:0008784 - alanine racemase activity

References:

GO:0030170 - pyridoxal phosphate binding

References:

Modification

MOD:00128 - N6-pyridoxal phosphate-L-lysine

References:

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

References:

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000311 - inviable after spore germination with normal, unseptated germ tube morphology

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

Warnings

PBO:0000085 - possible horizontal transfer

References:

Protein features

IDNameInterPro nameDB name
PF01168Ala_racemase_NAla_racemase_NPFAM
PF00842Ala_racemase_CAla_racemase_CPFAM
cd06827PLPDE_III_AR_proteobactCDD
PS00395ALANINE_RACEMASEAla_racemase_pyridoxalP-BSPROSITE_PATTERNS
SM01005Ala_racemase_C_2Ala_racemase_CSMART
PR00992ALARACEMASEAla_racemasePRINTS
G3DSA:3.20.20.10:FF:000002FUNFAM
SSF50621Alanine racemase C-terminal domain-likeAla_racemase/Decarboxylase_CSUPERFAMILY
SSF51419PLP-binding barrelPLP-binding_barrelSUPERFAMILY
G3DSA:3.20.20.10Alanine racemasePLP-binding_barrelGENE3D
G3DSA:2.40.37.10Lyase, Ornithine Decarboxylase; Chain A, domain 1Ala_racemase/Decarboxylase_CGENE3D
PTHR30511ALANINE RACEMASEAla_racemasePANTHER
MF_01201Ala_racemaseAla_racemaseHAMAP
TIGR00492alrAla_racemaseNCBIFAM

References / Literature

PMID:22235339 - The S. pombe histone H2A dioxygenase Ofd2 regulates gene expression during hypoxia.
Lando D et al. PLoS One 2012;7(1):e29765
PMID:21317872 - Red1 promotes the elimination of meiosis-specific mRNAs in vegetatively growing fission yeast.
Sugiyama T et al. EMBO J 2011 Mar 16;30(6):1027-39
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:12529438 - Global transcriptional responses of fission yeast to environmental stress.
Chen D et al. Mol Biol Cell 2003 Jan;14(1):214-29
PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.
Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7
PMID:38899862 - Suppression of inositol pyrophosphate toxicosis and hyper-repression of the fission yeast PHO regulon by loss-of-function mutations in chromatin remodelers Snf22 and Sol1.
Schwer B et al. mBio 2024 Jun 20;:e0125224
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:32896087 - Mitochondrial respiration is required to provide amino acids during fermentative proliferation of fission yeast.
Malecki M et al. EMBO Rep 2020 Nov 05;21(11):e50845
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:23658229 - Red5 and three nuclear pore components are essential for efficient suppression of specific mRNAs during vegetative growth of fission yeast.
Sugiyama T et al. Nucleic Acids Res 2013 Jul;41(13):6674-86
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:27053105 - Mga2 Transcription Factor Regulates an Oxygen-responsive Lipid Homeostasis Pathway in Fission Yeast.
Burr R et al. J Biol Chem 2016 Jun 03;291(23):12171-83
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31