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protein coding gene - abc3 (SPBC359.05) - vacuolar heme ABC transmembrane exporter Abc3

Gene summary

Standard name
abc3
Systematic ID
SPBC359.05
Product
vacuolar heme ABC transmembrane exporter Abc3
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9P5N0
ORFeome ID
39/39E06
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 122642..127461 forward strand

Annotation

Disease association

MONDO:0013768 - arterial calcification, generalized, of infancy, 2

References:

MONDO:0009925 - autosomal recessive inherited pseudoxanthoma elasticum

References:

MONDO:0009380 - Dubin-Johnson syndrome

References:

MONDO:0030058 - hearing loss, autosomal dominant 77

References:

MONDO:0008333 - pseudoxanthoma elasticum, forme fruste

References:

GO biological process

GO:0140357 - heme export from vacuole to cytoplasm

References:

GO cellular component

GO:0000324 - fungal-type vacuole

References:

GO:0000329 - fungal-type vacuole membrane

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GO:0016020 - membrane

References:

GO:0005774 - vacuolar membrane

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GO molecular function

GO:0015439 - ABC-type heme transporter activity

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GO:0005524 - ATP binding

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GO:0016887 - ATP hydrolysis activity

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GO:0020037 - heme binding

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Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:01148 - ubiquitinylated lysine

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Multi-locus phenotype

FYPO:0004911 - abolished glutathione import into vacuole

References:

Genotypes:

FYPO:0002829 - decreased cellular phytochelatin level

References:

Genotypes:

FYPO:0002243 - increased acid phosphatase activity

References:

Genotypes:

FYPO:0004247 - normal vacuolar morphology during vegetative growth

References:

Genotypes:

FYPO:0001357 - normal vegetative cell population growth

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Genotypes:

FYPO:0001420 - normal vegetative cell population growth rate

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Genotypes:

FYPO:0004912 - phytochelatin absent from vacuole

References:

Genotypes:

FYPO:0000096 - sensitive to cadmium

References:

Genotypes:

FYPO:0002015 - sensitive to iron ion starvation

References:

Genotypes:

FYPO:0001234 - slow vegetative cell population growth

References:

Genotypes:

Protein features

PBO:0111874 - ABC transporter family

References:

PBO:0111875 - MDR subfamily

Protein sequence feature

SO:0001812 - transmembrane_helix

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Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PomGeneEx:0000012 - RNA level decreased

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PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000684 - decreased cell population growth on glycerol carbon source

References:

Genotypes:

FYPO:0009073 - decreased cell population growth on lysine nitrogen source

References:

Genotypes:

FYPO:0004698 - decreased heme binding

References:

Genotypes:

FYPO:0006890 - decreased heme export from vacuole

References:

Genotypes:

FYPO:0001852 - decreased transcription during iron starvation

References:

Genotypes:

FYPO:0009093 - increased cell population growth on lysine and serine nitrogen source

References:

Genotypes:

FYPO:0009098 - increased cell population growth on mannitol carbon source

References:

Genotypes:

FYPO:0000636 - increased cell population growth rate

References:

Genotypes:

FYPO:0002006 - increased cellular iron level

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Genotypes:

FYPO:0000780 - increased transcription during vegetative growth

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Genotypes:

FYPO:0001309 - increased viability in stationary phase

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Genotypes:

FYPO:0003849 - normal growth on fluconazole

References:

Genotypes:

FYPO:0003852 - normal growth on FR901464

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Genotypes:

FYPO:0000979 - normal growth on miconazole

References:

Genotypes:

FYPO:0003851 - normal growth on MTT

References:

Genotypes:

FYPO:0003850 - normal growth on oligomycin

References:

Genotypes:

FYPO:0003719 - normal growth on tributyltin

References:

Genotypes:

FYPO:0002620 - normal growth on trichostatin A

References:

Genotypes:

FYPO:0004248 - normal protein localization to vacuolar membrane

References:

Genotypes:

FYPO:0002693 - resistance to diamide

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Genotypes:

FYPO:0001453 - resistance to ethanol

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Genotypes:

FYPO:0001583 - resistance to lithium

References:

Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0005193 - resistance to torin1

References:

Genotypes:

FYPO:0000830 - resistance to vanadate

References:

Genotypes:

FYPO:0000095 - sensitive to bleomycin

References:

Genotypes:

FYPO:0002237 - sensitive to cerulenin

References:

Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0009088 - sensitive to magnesium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF00005ABC_tranABC_transporter-like_ATP-bdPFAM
PF00664ABC_membraneABC1_TM_domPFAM
cd03244ABCC_MRP_domain2CDD
cd03250ABCC_MRP_domain1CDD
cd18595ABC_6TM_MRP1_2_3_6_D1_likeCDD
cd18580ABC_6TM_ABCC_D2ABCC_6TM_D2CDD
PS00211ABC_TRANSPORTER_1ABC_transporter-like_CSPROSITE_PATTERNS
PS50893ABC_TRANSPORTER_2ABC_transporter-like_ATP-bdPROSITE_PROFILES
PS50929ABC_TM1FABC1_TM_domPROSITE_PROFILES
SM00382AAA_5AAA+_ATPaseSMART
G3DSA:1.20.1560.10:FF:000020FUNFAM
G3DSA:1.20.1560.10:FF:000001FUNFAM
G3DSA:3.40.50.300:FF:000997FUNFAM
G3DSA:3.40.50.300:FF:000565FUNFAM
SSF52540P-loop containing nucleoside triphosphate hydrolasesP-loop_NTPaseSUPERFAMILY
SSF90123ABC transporter transmembrane regionABC1_TM_sfSUPERFAMILY
G3DSA:3.40.50.300P-loop_NTPaseGENE3D
G3DSA:1.20.1560.10ABC transporter type 1, transmembrane domainABC1_TM_sfGENE3D
PTHR24223ATP-BINDING CASSETTE SUB-FAMILY CABC_transporter_C-likePANTHER
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder

Orthologs

References / Literature

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:38899862 - Suppression of inositol pyrophosphate toxicosis and hyper-repression of the fission yeast PHO regulon by loss-of-function mutations in chromatin remodelers Snf22 and Sol1.
Schwer B et al. mBio 2024 Jun 20;:e0125224
GO_REF:0000002 - Comments
PMID:12529438 - Global transcriptional responses of fission yeast to environmental stress.
Chen D et al. Mol Biol Cell 2003 Jan;14(1):214-29
PMID:20937798 - Tonoplast-localized Abc2 transporter mediates phytochelatin accumulation in vacuoles and confers cadmium tolerance.
Mendoza-Cózatl DG et al. J Biol Chem 2010 Dec 24;285(52):40416-26
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:16849797 - A survey of all 11 ABC transporters in fission yeast: two novel ABC transporters are required for red pigment accumulation in a Schizosaccharomyces pombe adenine biosynthetic mutant.
Iwaki T et al. Microbiology (Reading) 2006 Aug;152(Pt 8):2309-2321
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:29549126 - The major facilitator transporter Str3 is required for low-affinity heme acquisition in Schizosaccharomyces pombe .
Normant V et al. J Biol Chem 2018 Apr 27;293(17):6349-6362
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:19915076 - abc3+ encodes an iron-regulated vacuolar ABC-type transporter in Schizosaccharomyces pombe.
Pouliot B et al. Eukaryot Cell 2010 Jan;9(1):59-73
PMID:24385927 - The PAF complex and Prf1/Rtf1 delineate distinct Cdk9-dependent pathways regulating transcription elongation in fission yeast.
Mbogning J et al. PLoS Genet 2013;9(12):e1004029
PMID:21297349 - Bfr1p is responsible for tributyltin resistance in Schizosaccharomyces pombe.
Akiyama K et al. J Toxicol Sci 2011 Jan;36(1):117-20
PMID:28193844 - Heme Assimilation in Schizosaccharomyces pombe Requires Cell-surface-anchored Protein Shu1 and Vacuolar Transporter Abc3.
Mourer T et al. J Biol Chem 2017 Mar 24;292(12):4898-4912
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:35820914 - Antagonistic effects of mitochondrial matrix and intermembrane space proteases on yeast aging.
Vega M et al. BMC Biol 2022 Jul 12;20(1):160
PMID:23163955 - Analysis of stress-induced duplex destabilization (SIDD) properties of replication origins, genes and intergenes in the fission yeast, Schizosaccharomyces pombe.
Yadav MP et al. BMC Res Notes 2012 Nov 19;5:643
PMID:21340088 - Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.
Arita Y et al. Mol Biosyst 2011 May;7(5):1463-72
PMID:22840777 - Analyzing fission yeast multidrug resistance mechanisms to develop a genetically tractable model system for chemical biology.
Kawashima SA et al. Chem Biol 2012 Jul 27;19(7):893-901
PMID:25452419 - Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.
Sideri T et al. G3 (Bethesda) 2014 Dec 01;5(1):145-55