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protein coding gene - cox10 (SPBC365.02c) - protoheme IX farnesyltransferase

Gene summary

Standard name
cox10
Systematic ID
SPBC365.02c
Product
protoheme IX farnesyltransferase
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9Y7Y4
ORFeome ID
43/43H07
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 2501202..2502662 reverse strand

Annotation

Disease association

MONDO:0033635 - mitochondrial complex IV deficiency, nuclear type 3

References:

GO biological process

GO:0006784 - heme A biosynthetic process

References:

GO cellular component

GO:0099617 - matrix side of mitochondrial inner membrane

References:

GO:0005739 - mitochondrion

References:

GO molecular function

GO:0008495 - protoheme IX farnesyltransferase activity

References:

Protein sequence feature

SO:0001808 - mitochondrial_targeting_signal

References:

SO:0001812 - transmembrane_helix

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0008143 - heme A absent from cell

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF01040UbiAUbiA_prenyltransferasePfam
cd13957PT_UbiA_Cox10Protohaem_IX_farnesylTrfaseCDD
PS00943UBIAUbiA_prenylTrfase_CSPROSITE patterns
G3DSA:1.10.357.140:FF:000004CATH-FunFam
G3DSA:1.10.357.140UbiA_sfCATH-Gene3D
PTHR43448Protohaem_IX_farnesylTrfasePANTHER
PIRSF001773COX10Protohaem_IX_farnesylTrfase_mtPIRSF
TIGR01473cyoE_ctaBProtohaem_IX_farnesylTrfaseNCBIFAM
Transmembrane alpha helixDeepTMHMM
MF_00154CyoE_CtaBProtohaem_IX_farnesylTrfaseHAMAP

Orthologs

References / Literature

PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:33109728 - High-Throughput Identification of Nuclear Envelope Protein Interactions in Schizosaccharomyces pombe Using an Arrayed Membrane Yeast-Two Hybrid Library.
Varberg JM et al. G3 (Bethesda) 2020 Dec 03;10(12):4649-4663
PMID:30824696 - Systematic analysis reveals the prevalence and principles of bypassable gene essentiality.
Li J et al. Nat Commun 2019 Mar 01;10(1):1002
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:11248251 - Involvement of mitochondrial ferredoxin and Cox15p in hydroxylation of heme O.
Barros MH et al. FEBS Lett 2001 Mar 09;492(1-2):133-8
GO_REF:0000033 - Annotation inferences using phylogenetic trees