protein coding gene - cox10 (SPBC365.02c) - protoheme IX farnesyltransferase

Gene summary

Standard name: cox10
Systematic ID: SPBC365.02c
Product: protoheme IX farnesyltransferase
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: Q9Y7Y4
ORFeome ID: 43/43H07
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome II: 2501202..2502662 reverse strand

Annotation

Disease association

MONDO:0033635 - mitochondrial complex IV deficiency, nuclear type 3

References:

PB_REF:0000006

GO biological process

GO:0006784 - heme A biosynthetic process

References:

PMID:11248251

GO cellular component

GO:0099617 - matrix side of mitochondrial inner membrane

References:

GO_REF:0000024

GO:0005739 - mitochondrion

References:

PMID:16823372

GO molecular function

GO:0008495 - protoheme IX farnesyltransferase activity

References:

GO_REF:0000033

Protein sequence feature

SO:0001808 - mitochondrial_targeting_signal

References:

PMID:36408920

SO:0001812 - transmembrane_helix

References:

PMID:11152613

Quantitative gene expression

PBO:0006310 - protein level

References:

PMID:24763107

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0008143 - heme A absent from cell

References:

PMID:11248251

Genotypes:

cox10delta

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

cox10delta

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

PMID:23697806

Genotypes:

cox10delta

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

ID	Name	InterPro name	DB name
PF01040	UbiA	UbiA_prenyltransferase	PFAM
cd13957	PT_UbiA_Cox10	Protohaem_IX_farnesylTrfase	CDD
PS00943	UBIA	UbiA_prenylTrfase_CS	PROSITE_PATTERNS
G3DSA:1.10.357.140:FF:000004			FUNFAM
G3DSA:1.10.357.140	UbiA prenyltransferase	UbiA_sf	GENE3D
PTHR43448	PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL	Protohaem_IX_farnesylTrfase	PANTHER
PIRSF001773	COX10	Protohaem_IX_farnesylTrfase_mt	PIRSF
MF_00154	CyoE_CtaB	Protohaem_IX_farnesylTrfase	HAMAP
TIGR01473	cyoE_ctaB	Protohaem_IX_farnesylTrfase	NCBIFAM

Orthologs

COX10 (HGNC:2260) Homo sapiens
cox10 (SJAG_03173) Schizosaccharomyces japonicus
COX10 (YPL172C) Saccharomyces cerevisiae

References / Literature

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.: Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:11248251 - Involvement of mitochondrial ferredoxin and Cox15p in hydroxylation of heme O.: Barros MH et al. FEBS Lett 2001 Mar 09;492(1-2):133-8
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.: Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.: Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:30824696 - Systematic analysis reveals the prevalence and principles of bypassable gene essentiality.: Li J et al. Nat Commun 2019 Mar 01;10(1):1002
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.: UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:33109728 - High-Throughput Identification of Nuclear Envelope Protein Interactions in Schizosaccharomyces pombe Using an Arrayed Membrane Yeast-Two Hybrid Library.: Varberg JM et al. G3 (Bethesda) 2020 Dec 03;10(12):4649-4663
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs