protein coding gene - pmt3 (SPBC365.06) - ubiquitin-like protein modifier SUMO

Gene summary

Standard name

pmt3

Systematic ID

SPBC365.06

Product

ubiquitin-like protein modifier SUMO

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

ubl2, smt3

UniProt ID

O13351

ORFeome ID

31/31E04

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 2506845..2510260 forward strand

Annotation

Protein features

Orthologs

• SUMO3 (HGNC:11124) Homo sapiens
• SUMO2 (HGNC:11125) Homo sapiens
• SUMO1 (HGNC:12502) Homo sapiens
• SUMO4 (HGNC:21181) Homo sapiens
• pmt3 (SJAG_03843) Schizosaccharomyces japonicus
• SMT3 (YDR510W) Saccharomyces cerevisiae

References / Literature

PMID:23828040 - Involvement of Schizosaccharomyces pombe rrp1+ and rrp2+ in the Srs2- and Swi5/Sfr1-dependent pathway in response to DNA damage and replication inhibition.

Dziadkowiec D et al. Nucleic Acids Res 2013 Sep;41(17):8196-209

PMID:29162938 - RNA metabolism is the primary target of formamide in vivo.

Hoyos-Manchado R et al. Sci Rep 2017 Nov 21;7(1):15895

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.

Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)

PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.

Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31

PMID:41330900 - PolySUMOylation of PCNA and Rad52 restricts centromeric recombination in fission yeast.

Markowska K et al. Nat Commun 2025 Dec 02;16(1):10837

PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.

Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:17762864 - Conserved function of RNF4 family proteins in eukaryotes: targeting a ubiquitin ligase to SUMOylated proteins.

Sun H et al. EMBO J 2007 Sep 19;26(18):4102-12

PMID:24818994 - The S. pombe translation initiation factor eIF4G is Sumoylated and associates with the SUMO protease Ulp2.

Jongjitwimol J et al. PLoS One 2014;9(5):e94182

PMID:17762865 - SUMO-targeted ubiquitin ligases in genome stability.

Prudden J et al. EMBO J 2007 Sep 19;26(18):4089-101

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:11600706 - SUMO modification of Rad22, the Schizosaccharomyces pombe homologue of the recombination protein Rad52.

Ho JC et al. Nucleic Acids Res 2001 Oct 15;29(20):4179-86

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:11820777 - Isolation and characterization of a novel F-box protein Pof10 in fission yeast.

Ikebe C et al. Biochem Biophys Res Commun 2002 Feb 08;290(5):1399-407

PMID:29216371 - Fission yeast Ccq1 is a modulator of telomerase activity.

Armstrong CA et al. Nucleic Acids Res 2018 Jan 25;46(2):704-716

PMID:19756689 - SUMOylation is required for normal development of linear elements and wild-type meiotic recombination in Schizosaccharomyces pombe.

Spirek M et al. Chromosoma 2010 Feb;119(1):59-72

PMID:24925530 - Tpz1TPP1 SUMOylation reveals evolutionary conservation of SUMO-dependent Stn1 telomere association.

Garg M et al. EMBO Rep 2014 Aug;15(8):871-7

PMID:11452028 - Expression of hsp16 in response to nucleotide depletion is regulated via the spc1 MAPK pathway in Schizosaccharomyces pombe.

Taricani L et al. Nucleic Acids Res 2001 Jul 15;29(14):3030-40

PMID:12597774 - Characterization of SUMO-conjugating enzyme mutants in Schizosaccharomyces pombe identifies a dominant-negative allele that severely reduces SUMO conjugation.

Ho JC et al. Biochem J 2003 May 15;372(Pt 1):97-104

PMID:19416828 - Schizosaccharomyces pombe Rtf2 mediates site-specific replication termination by inhibiting replication restart.

Inagawa T et al. Proc Natl Acad Sci U S A 2009 May 12;106(19):7927-32

PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:28552615 - SUMO-Targeted DNA Translocase Rrp2 Protects the Genome from Top2-Induced DNA Damage.

Wei Y et al. Mol Cell 2017 Jun 01;66(5):581-596.e6

PMID:24711392 - SUMOylation regulates telomere length by targeting the shelterin subunit Tpz1(Tpp1) to modulate shelterin-Stn1 interaction in fission yeast.

Miyagawa K et al. Proc Natl Acad Sci U S A 2014 Apr 22;111(16):5950-5

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:39786922 - The fission yeast SUMO-targeted ubiquitin ligase Slx8 functionally associates with clustered centromeres and the silent mating-type region at the nuclear periphery.

Chakraborty S et al. Biol Open 2024 Dec 15;13(12)

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:28475613 - SUMO-targeted ubiquitin ligase activity can either suppress or promote genome instability, depending on the nature of the DNA lesion.

Nie M et al. PLoS Genet 2017 May;13(5):e1006776

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:26787556 - Crystal structure and SUMO binding of Slx1-Slx4 complex.

Lian FM et al. Sci Rep 2016 Jan 20;6:19331

PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.

Køhler JB et al. Nat Commun 2015 Nov 05;6:8827

PMID:33159083 - The nuclear pore primes recombination-dependent DNA synthesis at arrested forks by promoting SUMO removal.

Kramarz K et al. Nat Commun 2020 Nov 06;11(1):5643

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:29774234 - The fission yeast Stn1-Ten1 complex limits telomerase activity via its SUMO-interacting motif and promotes telomeres replication.

Matmati S et al. Sci Adv 2018 May;4(5):eaar2740

PMID:15932060 - The telomere-binding protein Taz1p as a target for modification by a SUMO-1 homologue in fission yeast.

Spink K et al. Biochem Genet 2005 Apr;43(3-4):103-17

PMID:19264558 - Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance.

Deshpande GP et al. DNA Repair (Amst) 2009 May 01;8(5):672-9

PMID:30824696 - Systematic analysis reveals the prevalence and principles of bypassable gene essentiality.

Li J et al. Nat Commun 2019 Mar 01;10(1):1002

PMID:20625380 - A genome-wide screen for Schizosaccharomyces pombe deletion mutants that affect telomere length.

Liu NN et al. Cell Res 2010 Aug;20(8):963-5

PMID:38917328 - SUMO protease and proteasome recruitment at the nuclear periphery differently affect replication dynamics at arrested forks.

Schirmeisen K et al. Nucleic Acids Res 2024 Jun 25;

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:18931302 - Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes.

Dixon SJ et al. Proc Natl Acad Sci U S A 2008 Oct 28;105(43):16653-8

PMID:15359282 - Role of the fission yeast SUMO E3 ligase Pli1p in centromere and telomere maintenance.

Xhemalce B et al. EMBO J 2004 Oct 01;23(19):3844-53

PMID:28180297 - Fission yeast Stn1 is crucial for semi-conservative replication at telomeres and subtelomeres.

Takikawa M et al. Nucleic Acids Res 2017 Feb 17;45(3):1255-1269

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:39880258 - Determination of enzyme kinetic parameters of fast-acting Schizosaccharomyces pombe Ulp1 catalytic domain using Forster resonance energy transfer (FRET) assay.

Babbal SM et al. Int J Biol Macromol 2025 Jan 27;:140312

PMID:10567589 - Characterization of a fission yeast SUMO-1 homologue, pmt3p, required for multiple nuclear events, including the control of telomere length and chromosome segregation.

Tanaka K et al. Mol Cell Biol 1999 Dec;19(12):8660-72

PMID:26221037 - Pli1(PIAS1) SUMO ligase protected by the nuclear pore-associated SUMO protease Ulp1SENP1/2.

Nie M et al. J Biol Chem 2015 Sep 11;290(37):22678-85

PMID:14745200 - Truncated Sla1 induces haploid meiosis through the Pat1-Mei2 system in fission yeast.

Tanabe K et al. Biosci Biotechnol Biochem 2004 Jan;68(1):266-70

PMID:22730331 - Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions.

Nie M et al. J Biol Chem 2012 Aug 24;287(35):29610-9

PMID:26404184 - High Confidence Fission Yeast SUMO Conjugates Identified by Tandem Denaturing Affinity Purification.

Nie M et al. Sci Rep 2015 Sep 25;5:14389

PMID:11884512 - Cell-cycle-dependent localisation of Ulp1, a Schizosaccharomyces pombe Pmt3 (SUMO)-specific protease.

Taylor DL et al. J Cell Sci 2002 Mar 15;115(Pt 6):1113-22

PMID:25795664 - Genetic Interaction Landscape Reveals Critical Requirements for Schizosaccharomyces pombe Brc1 in DNA Damage Response Mutants.

Sánchez A et al. G3 (Bethesda) 2015 Mar 19;5(5):953-62

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:28821619 - Dsc E3 ligase localization to the Golgi requires the ATPase Cdc48 and cofactor Ufd1 for activation of sterol regulatory element-binding protein in fission yeast.

Burr R et al. J Biol Chem 2017 Sep 29;292(39):16333-16350

PMID:21247416 - Ubiquitin-proteasome genes as targets for modulation of cisplatin sensitivity in fission yeast.

Gatti L et al. BMC Genomics 2011 Jan 19;12:44

PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.

Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85

PMID:21444718 - DNA repair and global sumoylation are regulated by distinct Ubc9 noncovalent complexes.

Prudden J et al. Mol Cell Biol 2011 Jun;31(11):2299-310

PMID:31072933 - Suppressor screening reveals common kleisin-hinge interaction in condensin and cohesin, but different modes of regulation.

Xu X et al. Proc Natl Acad Sci U S A 2019 May 28;116(22):10889-10898