protein coding gene - gcn2 (SPBC36B7.09) - eIF2 alpha kinase Gcn2

Gene summary

Standard name

gcn2

Systematic ID

SPBC36B7.09

Product

eIF2 alpha kinase Gcn2

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

ppk28, SPBP18G5.01

UniProt ID

Q9HGN1

ORFeome ID

50/50B01

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 2396432..2401552 forward strand

Annotation

Protein features

Orthologs

• EIF2AK4 (HGNC:19687) Homo sapiens
• gcn2 (SJAG_00169) Schizosaccharomyces japonicus
• GCN2 (YDR283C) Saccharomyces cerevisiae

References / Literature

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:20444689 - Methylation of ribosomal protein L42 regulates ribosomal function and stress-adapted cell growth.

Shirai A et al. J Biol Chem 2010 Jul 16;285(29):22448-60

PMID:21340088 - Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.

Arita Y et al. Mol Biosyst 2011 May;7(5):1463-72

PMID:33970532 - Magnesium depletion extends fission yeast lifespan via general amino acid control activation.

Ohtsuka H et al. Microbiologyopen 2021 Mar;10(2):e1176

PMID:19033384 - The G1-S checkpoint in fission yeast is not a general DNA damage checkpoint.

Krohn M et al. J Cell Sci 2008 Dec 15;121(Pt 24):4047-54

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.

Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.

Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895

PMID:23108671 - Fission yeast TORC1 prevents eIF2α phosphorylation in response to nitrogen and amino acids via Gcn2 kinase.

Valbuena N et al. J Cell Sci 2012 Dec 15;125(Pt 24):5955-9

PMID:36478272 - Translation-complex profiling of fission yeast cells reveals dynamic rearrangements of scanning ribosomal subunits upon nutritional stress.

Duncan CDS et al. Nucleic Acids Res 2022 Dec 09;50(22):13011-13025

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:15821139 - Systematic deletion analysis of fission yeast protein kinases.

Bimbó A et al. Eukaryot Cell 2005 Apr;4(4):799-813

PMID:16278445 - Stress-activated protein kinase pathway functions to support protein synthesis and translational adaptation in response to environmental stress in fission yeast.

Dunand-Sauthier I et al. Eukaryot Cell 2005 Nov;4(11):1785-93

PMID:24333428 - Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2.

Cambiaghi TD et al. Biochem Biophys Res Commun 2014 Jan 10;443(2):592-7

PMID:26493332 - Stress-induced inhibition of translation independently of eIF2α phosphorylation.

Knutsen JH et al. J Cell Sci 2015 Dec 01;128(23):4420-7

PMID:33534698 - Tripartite suppression of fission yeast TORC1 signaling by the GATOR1-Sea3 complex, the TSC complex, and Gcn2 kinase.

Fukuda T et al. Elife 2021 Feb 03;10

PMID:20547592 - Vgl1, a multi-KH domain protein, is a novel component of the fission yeast stress granules required for cell survival under thermal stress.

Wen WL et al. Nucleic Acids Res 2010 Oct;38(19):6555-66

PMID:24280780 - Crosstalk between the Tor and Gcn2 pathways in response to different stresses.

Rødland GE et al. Cell Cycle 2014;13(3):453-61

PMID:23671279 - Receptor for activated C-kinase (RACK1) homolog Cpc2 facilitates the general amino acid control response through Gcn2 kinase in fission yeast.

Tarumoto Y et al. J Biol Chem 2013 Jun 28;288(26):19260-8

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:18502752 - Int6/eIF3e promotes general translation and Atf1 abundance to modulate Sty1 MAPK-dependent stress response in fission yeast.

Udagawa T et al. J Biol Chem 2008 Aug 08;283(32):22063-75

PB_REF:0000003 - Disease Association Curation

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:28771613 - Activation of Gcn2 in response to different stresses.

Anda S et al. PLoS One 2017;12(8):e0182143

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:32841241 - Hypomodified tRNA in evolutionarily distant yeasts can trigger rapid tRNA decay to activate the general amino acid control response, but with different consequences.

De Zoysa T et al. PLoS Genet 2020 Aug;16(8):e1008893

PMID:23687372 - New roles of the fission yeast eIF2α kinases Hri1 and Gcn2 in response to nutritional stress.

Martín R et al. J Cell Sci 2013 Jul 15;126(Pt 14):3010-20

PMID:34085593 - Multiplexed suppression of TOR complex 1 induces autophagy during starvation.

Fukuda T et al. Autophagy 2021 Jul;17(7):1794-1795

PMID:38295128 - A connection between the ribosome and two S. pombe tRNA modification mutants subject to rapid tRNA decay.

De Zoysa T et al. PLoS Genet 2024 Jan 31;20(1):e1011146

PMID:17952063 - TOR signalling regulates mitotic commitment through the stress MAP kinase pathway and the Polo and Cdc2 kinases.

Petersen J et al. Nat Cell Biol 2007 Nov;9(11):1263-72

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:17369398 - A novel checkpoint mechanism regulating the G1/S transition.

Tvegård T et al. Genes Dev 2007 Mar 15;21(6):649-54

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:21098141 - Cellular stress induces cytoplasmic RNA granules in fission yeast.

Nilsson D et al. RNA 2011 Jan;17(1):120-33