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protein coding gene - arh1 (SPBC3B8.01c) - mitochondrial [2Fe-2S] cluster assembly NADPH-ferredoxin reductase Arh1

Gene summary

Standard name
arh1
Systematic ID
SPBC3B8.01c
Product
mitochondrial [2Fe-2S] cluster assembly NADPH-ferredoxin reductase Arh1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O59710
ORFeome ID
24/24B01
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 3397359..3399191 forward strand

Annotation

Disease association

MONDO:0060582 - auditory neuropathy-optic atrophy syndrome

References:

MONDO:0004069 - inborn mitochondrial metabolism disorder

References:

MONDO:0971174 - multiple mitochondrial dysfunctions syndrome 9b

References:

MONDO:0019497 - nonsyndromic genetic hearing loss

References:

MONDO:0003608 - optic atrophy

References:

GO biological process

GO:0044571 - [2Fe-2S] cluster assembly

References:

GO:0006744 - ubiquinone biosynthetic process

References:

GO cellular component

GO:0099128 - mitochondrial [2Fe-2S] assembly complex

References:

GO:0005743 - mitochondrial inner membrane

References:

GO:0005739 - mitochondrion

References:

GO molecular function

GO:0071949 - FAD binding

References:

GO:0008860 - ferredoxin-NAD+ reductase activity

References:

GO:0004324 - ferredoxin-NADP+ reductase activity

References:

Protein sequence feature

SO:0001808 - mitochondrial_targeting_signal

References:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0006435 - increased FAD binding

References:

Genotypes:

FYPO:0000951 - inviable small vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF07992Pyr_redox_2FAD/NAD-binding_domPfam
PR00419ADXRDTASEPRINTS
G3DSA:3.40.50.720CATH-Gene3D
G3DSA:3.50.50.60FAD/NAD-bd_sfCATH-Gene3D
SSF51971SUPERFAMILY
PTHR48467Ferredox_RdtasePANTHER
PIRSF000362FNRFerredox_Rdtase_adrenodPIRSF

Orthologs

References / Literature

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
GO_REF:0000051 - S. pombe keyword mapping
PMID:21536008 - Structural and thermodynamic characterization of the adrenodoxin-like domain of the electron-transfer protein Etp1 from Schizosaccharomyces pombe.
Müller JJ et al. J Inorg Biochem 2011 Jul;105(7):957-65
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:18399988 - The endogenous adrenodoxin reductase-like flavoprotein arh1 supports heterologous cytochrome P450-dependent substrate conversions in Schizosaccharomyces pombe.
Ewen KM et al. FEMS Yeast Res 2008 May;8(3):432-41
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:34660592 - Biogenesis of Iron-Sulfur Clusters and Their Role in DNA Metabolism.
Shi R et al. Front Cell Dev Biol 2021;9:735678
PMID:28965846 - FDXR Mutations Cause Sensorial Neuropathies and Expand the Spectrum of Mitochondrial Fe-S-Synthesis Diseases.
Paul A et al. Am J Hum Genet 2017 Oct 05;101(4):630-637
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531