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protein coding gene - rrn6 (SPBC3B8.11) - RNA polymerase I general transcription initiation factor subunit Rrn6

Gene summary

Standard name
rrn6
Systematic ID
SPBC3B8.11
Product
RNA polymerase I general transcription initiation factor subunit Rrn6
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O59719
ORFeome ID
38/38F05
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 3369297..3372287 reverse strand

Annotation

GO biological process

GO:0042790 - nucleolar large rRNA transcription by RNA polymerase I

References:

GO:0006361 - transcription initiation at RNA polymerase I promoter

References:

GO cellular component

GO:0005829 - cytosol

References:

GO:0005634 - nucleus

References:

GO:0070860 - RNA polymerase I core factor complex

References:

GO molecular function

GO:0001181 - RNA polymerase I general transcription initiation factor activity

References:

GO:0001179 - RNA polymerase I general transcription initiation factor binding

References:

GO:0001163 - RNA polymerase I transcription regulatory region sequence-specific DNA binding

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000059 - abnormal mitotic cell cycle

References:

Genotypes:

FYPO:0000314 - inviable after spore germination with elongated germ tube

References:

Genotypes:

FYPO:0001042 - inviable after spore germination, single or double cell division

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF10214Rrn6_beta-propRRN6_beta-propPfam
PF20639Rrn6_K-richRrn6_K-richPfam
PTHR28221RNA_pol_I-sp_TIF_RRN6-likePANTHER

Orthologs

References / Literature

PMID:12490702 - Characterization of the fission yeast ribosomal DNA binding factor: components share homology with Upstream Activating Factor and with SWI/SNF subunits.
Liu M et al. Nucleic Acids Res 2002 Dec 15;30(24):5347-59
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:23695164 - Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.
Das J et al. Sci Signal 2013 May 21;6(276):ra38
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83