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protein coding gene - srp101 (SPBC3B9.03) - signal recognition particle receptor alpha subunit Srp101

Gene summary

Standard name
srp101
Systematic ID
SPBC3B9.03
Product
signal recognition particle receptor alpha subunit Srp101
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O43032
ORFeome ID
26/26E12
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 3993391..3995471 forward strand

Annotation

GO biological process

GO:0006886 - intracellular protein transport

References:

GO:0006614 - SRP-dependent cotranslational protein targeting to membrane

References:

GO cellular component

GO:0005829 - cytosol

References:

GO:0005634 - nucleus

References:

GO:0005785 - signal recognition particle receptor complex

References:

GO molecular function

GO:0005525 - GTP binding

References:

GO:0003924 - GTPase activity

References:

GO:0005047 - signal recognition particle binding

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

References:

MOD:01148 - ubiquitinylated lysine

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002151 - inviable spore

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00448SRP54SRP54_GTPase_domPfam
PF02881SRP54_NSignal_recog_particl_SRP54_hlxPfam
PF04086SRP-alpha_NSRPRA_NPfam
cd14826SR_alpha_SRXCDD
PS00300SRP54SRP54_GTPase_domPROSITE patterns
SM00382AAAAAA+_ATPaseSMART
SM00962SRP54SRP54_GTPase_domSMART
SM00963SRP54_NSignal_recog_particl_SRP54_hlxSMART
G3DSA:1.20.120.140:FF:000009CATH-FunFam
G3DSA:3.40.50.300:FF:000566CATH-FunFam
G3DSA:1.20.120.140SRP54_N_sfCATH-Gene3D
G3DSA:3.30.450.60CATH-Gene3D
G3DSA:3.40.50.300P-loop_NTPaseCATH-Gene3D
SSF47364SRP/SRP_NSUPERFAMILY
SSF52540P-loop_NTPaseSUPERFAMILY
SSF64356Longin-like_dom_sfSUPERFAMILY
PTHR43134PANTHER
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder
mobidb-lite-Polyampholytedisorder_predictionMobiDB-Polyampholyte

Orthologs

References / Literature

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
GO_REF:0000002 - Comments
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.
Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
GO_REF:0000033 - Annotation inferences using phylogenetic trees
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)