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protein coding gene - mnh1 (SPBC3B9.08c) - exon junction complex subunit, Mago-nashi homolog Mnh1

Gene summary

Standard name
mnh1
Systematic ID
SPBC3B9.08c
Product
exon junction complex subunit, Mago-nashi homolog Mnh1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
magoh, mago
UniProt ID
O43037
ORFeome ID
09/09F05
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 4001529..4002695 reverse strand

Annotation

GO biological process

GO:0045292 - mRNA cis splicing, via spliceosome

References:

GO:0071030 - nuclear mRNA surveillance of spliceosomal pre-mRNA splicing

References:

GO cellular component

GO:0005829 - cytosol

References:

GO:0035145 - exon-exon junction complex

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GO:0005634 - nucleus

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Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

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Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0001894 - abnormal sporulation resulting in formation of ascus with more or fewer than four spores

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Genotypes:

FYPO:0009092 - decreased cell population growth on lysine and serine nitrogen source

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Genotypes:

FYPO:0007562 - decreased cell population growth on serine nitrogen source

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Genotypes:

FYPO:0008147 - decreased mRNA splicing, meiotic genes

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Genotypes:

FYPO:0003029 - decreased mRNA splicing, via spliceosome

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Genotypes:

FYPO:0004167 - increased cell population growth on glycerol carbon source

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Genotypes:

FYPO:0003947 - normal nonsense-mediated decay

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Genotypes:

FYPO:0009041 - resistance to 2,2′-dipyridyl

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Genotypes:

FYPO:0000067 - resistance to brefeldin A

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Genotypes:

FYPO:0000764 - resistance to cycloheximide

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0001583 - resistance to lithium

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Genotypes:

FYPO:0001034 - resistance to tunicamycin

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Genotypes:

FYPO:0000830 - resistance to vanadate

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Genotypes:

FYPO:0000096 - sensitive to cadmium

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Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0000055 - no apparent S. cerevisiae ortholog

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0004337 - non-consensus GC donor

Protein features

IDNameInterPro nameDB name
PF02792Mago_nashiMago_nashiPfam
cd11295Mago_nashiMago_nashiCDD
G3DSA:3.30.1560.10:FF:000001CATH-FunFam
G3DSA:3.30.1560.10Mago_nashi_sfCATH-Gene3D
SSF89817Mago_nashi_sfSUPERFAMILY
PTHR12638Mago_nashiPANTHER

Orthologs

References / Literature

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:23173672 - Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.
Pan X et al. BMC Genomics 2012 Nov 23;13:662
PMID:22144913 - Widespread cotranslational formation of protein complexes.
Duncan CD et al. PLoS Genet 2011 Dec;7(12):e1002398
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:27365210 - The fission yeast MTREC and EJC orthologs ensure the maturation of meiotic transcripts during meiosis.
Marayati BF et al. RNA 2016 Sep;22(9):1349-59
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:36095128 - Splicing of branchpoint-distant exons is promoted by Cactin, Tls1 and the ubiquitin-fold-activated Sde2.
Anil AT et al. Nucleic Acids Res 2022 Sep 23;50(17):10000-10014
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:20360683 - Splicing-dependent NMD does not require the EJC in Schizosaccharomyces pombe.
Wen J et al. EMBO J 2010 May 05;29(9):1537-51
PMID:12618370 - Schizosaccharomyces pombe essential genes: a pilot study.
Decottignies A et al. Genome Res 2003 Mar;13(3):399-406