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protein coding gene - mrpl3 (SPBC3B9.14c) - mitochondrial ribosomal protein subunit L44

Gene summary

Standard name
mrpl3
Systematic ID
SPBC3B9.14c
Product
mitochondrial ribosomal protein subunit L44
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O43042
ORFeome ID
22/22D06
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 4009482..4010871 reverse strand

Annotation

Disease association

MONDO:0000732 - combined oxidative phosphorylation deficiency

References:

MONDO:0004069 - inborn mitochondrial metabolism disorder

References:

MONDO:0014162 - infantile hypertrophic cardiomyopathy due to MRPL44 deficiency

References:

GO biological process

GO:0032543 - mitochondrial translation

References:

GO:0006396 - RNA processing

References:

GO cellular component

GO:0005737 - cytoplasm

References:

GO:0005762 - mitochondrial large ribosomal subunit

References:

GO:0005739 - mitochondrion

References:

GO molecular function

GO:0003725 - double-stranded RNA binding

References:

GO:0004525 - ribonuclease III activity

References:

GO:0003735 - structural constituent of ribosome

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00696 - phosphorylated residue

References:

Protein sequence feature

SO:0001808 - mitochondrial_targeting_signal

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002111 - inviable tapered vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0002199 - inviable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00636Ribonuclease_3RNase_III_domPFAM
PF00035dsrmdsRBD_domPFAM
cd19873DSRM_MRPL3_likeRibosomal_mL44_DSRM_fungCDD
cd00593RIBOcRNase_III_domCDD
PS50142RNASE_3_2RNase_III_domPROSITE_PROFILES
SM00535riboneu5RNase_III_domSMART
SM00358DRBM_3dsRBD_domSMART
SSF69065RNase III domain-likeRNase_III_sfSUPERFAMILY
SSF54768dsRNA-binding domain-likeSUPERFAMILY
G3DSA:1.10.1520.10Ribonuclease III domainRNase_III_sfGENE3D
G3DSA:3.30.160.20GENE3D
PTHR11207RIBONUCLEASE IIIPANTHER

Orthologs

References / Literature

PMID:30321377 - Proteomic profiling and functional characterization of post-translational modifications of the fission yeast RNA exosome.
Telekawa C et al. Nucleic Acids Res 2018 Nov 30;46(21):11169-11183
PB_REF:0000003 - Disease Association Curation
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.
Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134
GO_REF:0000002 - Comments
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
GO_REF:0000033 - Annotation inferences using phylogenetic trees
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83