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protein coding gene - nup120 (SPBC3B9.16c) - nucleoporin, WD repeat Nup120

Gene summary

Standard name
nup120
Systematic ID
SPBC3B9.16c
Product
nucleoporin, WD repeat Nup120
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O43044
ORFeome ID
30/30E02
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 4015226..4018850 reverse strand

Annotation

Disease association

MONDO:0032582 - nephrotic syndrome, type 19

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GO biological process

GO:0016973 - poly(A)+ mRNA export from nucleus

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GO cellular component

GO:0005635 - nuclear envelope

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GO:0034399 - nuclear periphery

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GO:0005643 - nuclear pore

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GO:0031080 - nuclear pore outer ring

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GO molecular function

GO:0005515 - protein binding

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GO:0017056 - structural constituent of nuclear pore

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Qualitative gene expression

PomGeneEx:0000018 - protein level increased

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PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0003066 - abnormal sporulation resulting in formation of ascus with fewer than four spores

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Genotypes:

FYPO:0004481 - abolished cell population growth at high temperature

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Genotypes:

FYPO:0000705 - abolished protein-protein interaction

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Genotypes:

FYPO:0000080 - decreased cell population growth at low temperature

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Genotypes:

FYPO:0001407 - decreased cell population growth on glucose carbon source

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Genotypes:

FYPO:0001645 - decreased protein-protein interaction

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Genotypes:

FYPO:0002021 - dispersed actin cortical patch localization during vegetative growth

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Genotypes:

FYPO:0000825 - increased RNA level during vegetative growth

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Genotypes:

FYPO:0002148 - inviable after spore germination, multiple cell divisions, abnormal morphology

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Genotypes:

FYPO:0004118 - inviable after spore germination, multiple cell divisions, normal septum morphology

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0000355 - normal endoplasmic reticulum morphology

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Genotypes:

FYPO:0008103 - normal protein localization to perinuclear endoplasmic reticulum

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Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

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Genotypes:

FYPO:0000091 - sensitive to thiabendazole

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Genotypes:

FYPO:0003612 - viable spore population

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF11715Beta-prop_Nup120_160Beta-prop_Nup120_160Pfam
PF21486NUP120_helicalNup120_helicalPfam
PF23300HEAT_Nup120HEAT_Nup120Pfam
PTHR21286Nucleoporin_Nup160PANTHER

Orthologs

References / Literature

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:41259369 - Hydroxyurea induces an oxidative stress response that triggers ER expansion and cytoplasmic protein aggregation.
Sánchez-Molina A et al. PLoS Biol 2025 Nov 19;23(11):e3003493
PMID:23019579 - Structural evolution of the membrane-coating module of the nuclear pore complex.
Liu X et al. Proc Natl Acad Sci U S A 2012 Oct 09;109(41):16498-503
PMID:24637836 - Characterization of nuclear pore complex components in fission yeast Schizosaccharomyces pombe.
Asakawa H et al. Nucleus 2014;5(2):149-62
PMID:15116432 - Identification of genes encoding putative nucleoporins and transport factors in the fission yeast Schizosaccharomyces pombe: a deletion analysis.
Chen XQ et al. Yeast 2004 Apr 30;21(6):495-509
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:22955883 - Molecular basis for Nup37 and ELY5/ELYS recruitment to the nuclear pore complex.
Bilokapic S et al. Proc Natl Acad Sci U S A 2012 Sep 18;109(38):15241-6
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:32848252 - Closed mitosis requires local disassembly of the nuclear envelope.
Dey G et al. Nature 2020 Sep;585(7823):119-123
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:15226438 - The fission yeast Nup107-120 complex functionally interacts with the small GTPase Ran/Spi1 and is required for mRNA export, nuclear pore distribution, and proper cell division.
Baï SW et al. Mol Cell Biol 2004 Jul;24(14):6379-92
PMID:23658229 - Red5 and three nuclear pore components are essential for efficient suppression of specific mRNAs during vegetative growth of fission yeast.
Sugiyama T et al. Nucleic Acids Res 2013 Jul;41(13):6674-86
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:20970342 - Virtual breakdown of the nuclear envelope in fission yeast meiosis.
Asakawa H et al. Curr Biol 2010 Nov 09;20(21):1919-25
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PANTHER:PTHR21286 - Unknown title