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protein coding gene - vma7 (SPBC3B9.18c) - V-type ATPase V1 subunit F

Gene summary

Standard name
vma7
Systematic ID
SPBC3B9.18c
Product
V-type ATPase V1 subunit F
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O43046
ORFeome ID
03/03D07
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 4021130..4021849 reverse strand

Annotation

PBO:0000695 - 3.6.3.14

GO biological process

GO:1902600 - proton transmembrane transport

References:

GO cellular component

GO:0005829 - cytosol

References:

GO:0000329 - fungal-type vacuole membrane

References:

GO:0005634 - nucleus

References:

GO:0000221 - vacuolar proton-transporting V-type ATPase, V1 domain

References:

GO molecular function

GO:0016887 - ATP hydrolysis activity

References:

GO:0046961 - proton-transporting ATPase activity, rotational mechanism

References:

Modification

MOD:01148 - ubiquitinylated lysine

References:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000311 - inviable after spore germination with normal, unseptated germ tube morphology

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Genotypes:

FYPO:0002151 - inviable spore

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF01990ATP-synt_FATPase_V1-cplx_f_g_suPfam
G3DSA:3.40.50.10580:FF:000002CATH-FunFam
G3DSA:3.40.50.10580ATPase_V1_fsu_sfCATH-Gene3D
SSF159468ATPase_V1_fsu_sfSUPERFAMILY
PTHR13861PANTHER
PIRSF015945ATPase_V1_F_eukATPase_V1-cplx_fsu_eukPIRSF
TIGR01101V_ATP_synt_FATPase_V1-cplx_fsu_eukNCBIFAM

Orthologs

References / Literature

GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.
Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.
Paulo JA et al. J Proteomics 2020 Jan 06;210:103531
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)