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protein coding gene - dcp1 (SPBC3B9.21) - mRNA decapping complex regulatory subunit Dcp1

Gene summary

Standard name
dcp1
Systematic ID
SPBC3B9.21
Product
mRNA decapping complex regulatory subunit Dcp1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9P805
ORFeome ID
07/07D05
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 3996517..3997467 forward strand

Annotation

PBO:0001562 - 3.6.1.30

Complementation

PBO:0018076 - functionally complemented by human DCP1A

References:

PBO:0018077 - functionally complemented by human DCP1B

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PBO:0018075 - functionally complements S. cerevisiae DCP1

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GO biological process

GO:0000290 - deadenylation-dependent decapping of nuclear-transcribed mRNA

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GO:0110156 - mRNA methylguanosine-cap decapping

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GO:0000956 - nuclear-transcribed mRNA catabolic process

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GO cellular component

GO:0010494 - cytoplasmic stress granule

References:

GO:0005829 - cytosol

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GO:0005634 - nucleus

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GO:0000932 - P-body

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GO:0098745 - RNA decapping complex

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GO molecular function

GO:0170008 - mRNA phosphatase activator activity

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GO:0005515 - protein binding

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GO:0003723 - RNA binding

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000059 - abnormal mitotic cell cycle

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Genotypes:

FYPO:0003934 - abolished nuclear mRNA catabolic process

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Genotypes:

FYPO:0003941 - decreased m7G(5')pppN diphosphatase activity

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Genotypes:

FYPO:0003933 - decreased nuclear 5'-3' exonucleolytic mRNA catabolic process

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Genotypes:

FYPO:0003529 - inviable after spore germination, multiple cell divisions, cell cycle arrest in mitotic interphase, elongated cells

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0003932 - normal nuclear 5'-3' exonucleolytic mRNA catabolic process

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Genotypes:

FYPO:0000703 - normal protein-protein interaction

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Genotypes:

FYPO:0001357 - normal vegetative cell population growth

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF06058DCP1Dcp1Pfam
cd09804Dcp1CDD
G3DSA:2.30.29.30:FF:001123CATH-FunFam
G3DSA:2.30.29.30PH-like_dom_sfCATH-Gene3D
SSF50729SUPERFAMILY
PTHR16290Dcp1PANTHER

Orthologs

References / Literature

PMID:28472520 - A synergistic network of interactions promotes the formation of in vitro processing bodies and protects mRNA against decapping.
Schütz S et al. Nucleic Acids Res 2017 Jun 20;45(11):6911-6922
PMID:23319050 - Pdc1 functions in the assembly of P bodies in Schizosaccharomyces pombe.
Wang CY et al. Mol Cell Biol 2013 Mar;33(6):1244-53
PMID:18280239 - Structural basis of dcp2 recognition and activation by dcp1.
She M et al. Mol Cell 2008 Feb 15;29(3):337-49
PMID:20547592 - Vgl1, a multi-KH domain protein, is a novel component of the fission yeast stress granules required for cell survival under thermal stress.
Wen WL et al. Nucleic Acids Res 2010 Oct;38(19):6555-66
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:22907753 - Posttranscriptional regulation of cell-cell interaction protein-encoding transcripts by Zfs1p in Schizosaccharomyces pombe.
Wells ML et al. Mol Cell Biol 2012 Oct;32(20):4206-14
PMID:26896847 - Ensembl comparative genomics resources.
Herrero J et al. Database (Oxford) 2016;2016
PMID:16341225 - Crystal structure and functional analysis of Dcp2p from Schizosaccharomyces pombe.
She M et al. Nat Struct Mol Biol 2006 Jan;13(1):63-70
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:22323607 - Interdomain dynamics and coactivation of the mRNA decapping enzyme Dcp2 are mediated by a gatekeeper tryptophan.
Floor SN et al. Proc Natl Acad Sci U S A 2012 Feb 21;109(8):2872-7
PMID:15671491 - Decapping reaction of mRNA requires Dcp1 in fission yeast: its characterization in different species from yeast to human.
Sakuno T et al. J Biochem 2004 Dec;136(6):805-12
PMID:19430462 - Decapping is preceded by 3' uridylation in a novel pathway of bulk mRNA turnover.
Rissland OS et al. Nat Struct Mol Biol 2009 Jun;16(6):616-23
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:27694842 - Structural basis of mRNA-cap recognition by Dcp1-Dcp2.
Mugridge JS et al. Nat Struct Mol Biol 2016 Nov;23(11):987-994
PMID:15372076 - A chromodomain protein, Chp1, is required for the establishment of heterochromatin in fission yeast.
Sadaie M et al. EMBO J 2004 Oct 01;23(19):3825-35
PMID:28533364 - Changes in conformational equilibria regulate the activity of the Dcp2 decapping enzyme.
Wurm JP et al. Proc Natl Acad Sci U S A 2017 Jun 06;114(23):6034-6039
PMID:33946513 - The Putative RNA-Binding Protein Dri1 Promotes the Loading of Kinesin-14/Klp2 to the Mitotic Spindle and Is Sequestered into Heat-Induced Protein Aggregates in Fission Yeast.
Yukawa M et al. Int J Mol Sci 2021 Apr 30;22(9)
PMID:27183195 - Structure of the Dcp2-Dcp1 mRNA-decapping complex in the activated conformation.
Valkov E et al. Nat Struct Mol Biol 2016 Jun;23(6):574-9
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:32071154 - Fission Yeast Puf2, a Pumilio and FBF Family RNA-Binding Protein, Links Stress Granules to Processing Bodies.
Hsiao WY et al. Mol Cell Biol 2020 Apr 13;40(9)
PMID:33109728 - High-Throughput Identification of Nuclear Envelope Protein Interactions in Schizosaccharomyces pombe Using an Arrayed Membrane Yeast-Two Hybrid Library.
Varberg JM et al. G3 (Bethesda) 2020 Dec 03;10(12):4649-4663
PMID:22085934 - The structural basis of Edc3- and Scd6-mediated activation of the Dcp1:Dcp2 mRNA decapping complex.
Fromm SA et al. EMBO J 2012 Jan 18;31(2):279-90
PMID:29084823 - Phosphorylation of the RNA-binding protein Zfs1 modulates sexual differentiation in fission yeast.
Navarro FJ et al. J Cell Sci 2017 Dec 15;130(24):4144-4154
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:27354705 - The S. pombe mRNA decapping complex recruits cofactors and an Edc1-like activator through a single dynamic surface.
Wurm JP et al. RNA 2016 Sep;22(9):1360-72
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053