protein coding gene - dad4 (SPBC3B9.22c) - DASH complex subunit Dad4

Gene summary

Standard name: dad4
Systematic ID: SPBC3B9.22c
Product: DASH complex subunit Dad4
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: Q50HP4
ORFeome ID: 52/52E03
Characterisation status: biological role published
Feature type: mRNA gene
Genomic location: chromosome II: 4005063..4006382 reverse strand

Annotation

GO biological process

GO:1990758 - mitotic sister chromatid biorientation

References:

PMID:22375062

GO:1990976 - protein transport along microtubule to mitotic spindle pole body

References:

GO_REF:0000024

GO:0051455 - spindle attachment to meiosis I kinetochore

References:

GO_REF:0000111

GO cellular component

GO:0042729 - DASH complex

References:

PMID:16079914

GO:0072686 - mitotic spindle

References:

GO_REF:0000002

Modification

MOD:00046 - O-phospho-L-serine

References:

PMID:30726745

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

References:

PMID:27984744

Quantitative gene expression

PBO:0011963 - RNA level

References:

PMID:23101633

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011063 - conserved in fungi only

PBO:0006222 - predominantly single copy (one to one)

Protein features

ID	Name	InterPro name	DB name
PF08650	DASH_Dad4	DASH_Dad4	Pfam
PTHR28222		DASH_Dad4	PANTHER

Orthologs

dad4 (SJAG_05319) Schizosaccharomyces japonicus
DAD4 (YDR320C-A) Saccharomyces cerevisiae

References / Literature

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.: Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.: Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
GO_REF:0000002 - Comments
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.: Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:22375062 - Plo1 phosphorylates Dam1 to promote chromosome bi-orientation in fission yeast.: Buttrick GJ et al. J Cell Sci 2012 Apr 01;125(Pt 7):1645-51
PMID:23166349 - Csi1 links centromeres to the nuclear envelope for centromere clustering.: Hou H et al. J Cell Biol 2012 Nov 26;199(5):735-44
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:16079914 - Molecular analysis of kinetochore architecture in fission yeast.: Liu X et al. EMBO J 2005 Aug 17;24(16):2919-30
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83