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protein coding gene - gpi3 (SPBC3D6.07) - pig-A, phosphatidylinositol N-acetylglucosaminyltransferase subunit Gpi3

Gene summary

Standard name
gpi3
Systematic ID
SPBC3D6.07
Product
pig-A, phosphatidylinositol N-acetylglucosaminyltransferase subunit Gpi3
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
P87172
ORFeome ID
25/25D03
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 1282427..1284325 forward strand

Annotation

PBO:0003560 - 2.4.1.198

Disease association

MONDO:0018346 - ferro-cerebro-cutaneous syndrome

References:

MONDO:0010466 - multiple congenital anomalies-hypotonia-seizures syndrome 2

References:

MONDO:0010438 - paroxysmal nocturnal hemoglobinuria 1

References:

GO biological process

GO:0006506 - GPI anchor biosynthetic process

References:

GO cellular component

GO:0000506 - glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex

References:

GO molecular function

GO:0017176 - phosphatidylinositol N-acetylglucosaminyltransferase activity

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

References:

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0001042 - inviable after spore germination, single or double cell division

References:

Genotypes:

FYPO:0000313 - inviable after spore germination, without cell division, with abnormal germ tube morphology

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00534Glycos_transf_1Glyco_trans_1Pfam
PF08288PIGAPIGA_GPI_anchor_biosynthesisPfam
cd03796GT4_PIG-A-likePIG-A/GPI3CDD
G3DSA:3.40.50.2000:FF:000026CATH-FunFam
G3DSA:3.40.50.2000:FF:000053CATH-FunFam
G3DSA:3.40.50.2000CATH-Gene3D
SSF53756SUPERFAMILY
PTHR45871PANTHER

Orthologs

References / Literature

PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:30824696 - Systematic analysis reveals the prevalence and principles of bypassable gene essentiality.
Li J et al. Nat Commun 2019 Mar 01;10(1):1002
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs