protein coding gene - dpb4 (SPBC3D6.09) - DNA polymerase epsilon subunit Dpb4

Gene summary

Standard name

dpb4

Systematic ID

SPBC3D6.09

Product

DNA polymerase epsilon subunit Dpb4

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

P87174

ORFeome ID

10/10B08

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 1285946..1287121 forward strand

Annotation

Protein features

Orthologs

• POLE3 (HGNC:13546) Homo sapiens
• dpb4 (SJAG_04879) Schizosaccharomyces japonicus
• DPB4 (YDR121W) Saccharomyces cerevisiae

References / Literature

PMID:29109278 - Coordinated regulation of heterochromatin inheritance by Dpb3-Dpb4 complex.

He H et al. Proc Natl Acad Sci U S A 2017 Nov 21;114(47):12524-12529

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.

Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:38479839 - Coordination of histone chaperones for parental histone segregation and epigenetic inheritance.

Fang Y et al. Genes Dev 2024 Mar 13;

PMID:28281664 - Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.

Rallis C et al. Sci Rep 2017 Mar 10;7:44257

PMID:15388803 - Identification and cloning of two putative subunits of DNA polymerase epsilon in fission yeast.

Spiga MG et al. Nucleic Acids Res 2004;32(16):4945-53

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:25076038 - Large scale screening of genetic interaction with sgf73(+) in fission yeast.

Guo Y et al. Yi Chuan 2014 Jul;36(7):723-31

PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.

Blyth J et al. Genetics 2018 Feb;208(2):589-603

PMID:22718908 - DNA polymerization-independent functions of DNA polymerase epsilon in assembly and progression of the replisome in fission yeast.

Handa T et al. Mol Biol Cell 2012 Aug;23(16):3240-53

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:39094570 - A replisome-associated histone H3-H4 chaperone required for epigenetic inheritance.

Yu J et al. Cell 2024 Sep 05;187(18):5010-5028.e24

PMID:19109429 - GINS inactivation phenotypes reveal two pathways for chromatin association of replicative alpha and epsilon DNA polymerases in fission yeast.

Pai CC et al. Mol Biol Cell 2009 Feb;20(4):1213-22

PMID:24713849 - Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex.

Egan ED et al. RNA 2014 Jun;20(6):867-81

PMID:40861011 - Faithful inheritance: Parental histone recycling and epigenetic memory in fission yeast.

Fang Y et al. Cell Insight 2025 Oct;4(5):100275

PMID:33693625 - Dri1 mediates heterochromatin assembly via RNAi and histone deacetylation.

Ban H et al. Genetics 2021 May 17;218(1)