PomBase - protein coding gene - syf2 (SPBC3E7.13c) - Prp19 complex subunit Syf2 - The Schizosaccharomyces pombe genome database

ID	Name	InterPro name	DB name
PF08231	SYF2	mRNA_splic_SYF2	PFAM
PTHR13264	GCIP-INTERACTING PROTEIN P29	mRNA_splic_SYF2	PANTHER
Coil	Coil		COILS
mobidb-lite-Disorder	disorder_prediction		MOBIDB-Disorder
mobidb-lite-Polyampholyte	disorder_prediction		MOBIDB-Polyampholyte

References / Literature

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:11884590 - Proteomics analysis reveals stable multiprotein complexes in both fission and budding yeasts containing Myb-related Cdc5p/Cef1p, novel pre-mRNA splicing factors, and snRNAs.: Ohi MD et al. Mol Cell Biol 2002 Apr;22(7):2011-24
PMID:28446597 - The histone variant H2A.Z promotes splicing of weak introns.: Nissen KE et al. Genes Dev 2017 Apr 01;31(7):688-701
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.: Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:28947618 - Sde2 is an intron-specific pre-mRNA splicing regulator activated by ubiquitin-like processing.: Thakran P et al. EMBO J 2018 Jan 04;37(1):89-101
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:24442611 - Endogenous U2·U5·U6 snRNA complexes in S. pombe are intron lariat spliceosomes.: Chen W et al. RNA 2014 Mar;20(3):308-20
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:36361590 - Defining the Functional Interactome of Spliceosome-Associated G-Patch Protein Gpl1 in the Fission Yeast Schizosaccharomyces pombe .: Selicky T et al. Int J Mol Sci 2022 Oct 24;23(21)
PMID:20404563 - High-throughput knockout screen in Schizosaccharomyces pombe identifies a novel gene required for efficient homolog disjunction during meiosis I.: Rumpf C et al. Cell Cycle 2010 May;9(9):1802-8
PMID:21386897 - Systematic two-hybrid and comparative proteomic analyses reveal novel yeast pre-mRNA splicing factors connected to Prp19.: Ren L et al. PLoS One 2011 Feb 28;6(2):e16719
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.: Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:24874881 - The proper splicing of RNAi factors is critical for pericentric heterochromatin assembly in fission yeast.: Kallgren SP et al. PLoS Genet 2014;10(5):e1004334
PMID:26644575 - Discovery of a nucleocytoplasmic O-mannose glycoproteome in yeast.: Halim A et al. Proc Natl Acad Sci U S A 2015 Dec 22;112(51):15648-53
PMID:25274039 - A systematic genetic screen identifies new factors influencing centromeric heterochromatin integrity in fission yeast.: Bayne EH et al. Genome Biol 2014;15(10):481
PMID:31219728 - Identification of proteins associated with splicing factors Ntr1, Ntr2, Brr2 and Gpl1 in the fission yeast Schizosaccharomyces pombe .: Cipakova I et al. Cell Cycle 2019 Jul;18(14):1532-1536
PMID:24713849 - Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex.: Egan ED et al. RNA 2014 Jun;20(6):867-81
PMID:39833470 - Structures of aberrant spliceosome intermediates on their way to disassembly.: Soni K et al. Nat Struct Mol Biol 2025 Jan 20;
PMID:24014766 - Structural and functional characterization of the N terminus of Schizosaccharomyces pombe Cwf10.: Livesay SB et al. Eukaryot Cell 2013 Nov;12(11):1472-89
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.: Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.: Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:15755920 - Dim1p is required for efficient splicing and export of mRNA encoding lid1p, a component of the fission yeast anaphase-promoting complex.: Carnahan RH et al. Eukaryot Cell 2005 Mar;4(3):577-87

protein coding gene - syf2 (SPBC3E7.13c) - Prp19 complex subunit Syf2

Gene summary

Annotation

GO biological process

GO:0045292 - mRNA cis splicing, via spliceosome

GO cellular component

GO:0071013 - catalytic step 2 spliceosome

GO:0071014 - post-mRNA release spliceosomal complex

GO:0000974 - Prp19 complex

GO:0005681 - spliceosomal complex

GO:0071004 - U2-type prespliceosome

Modification

MOD:00595 - monomannosylated residue

MOD:00046 - O-phospho-L-serine

MOD:01148 - ubiquitinylated lysine

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

Quantitative gene expression

PBO:0006310 - protein level

PBO:0011963 - RNA level

Single locus phenotype

FYPO:0002420 - inviable after spore germination, single cell division, abnormal cell shape

FYPO:0002151 - inviable spore

FYPO:0002061 - inviable vegetative cell population

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

Orthologs

References / Literature