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protein coding gene - hpp5 (SPBC3F6.01c) - serine/threonine protein phosphatase with TPR repeat Hpp5

Gene summary

Standard name
hpp5
Systematic ID
SPBC3F6.01c
Product
serine/threonine protein phosphatase with TPR repeat Hpp5
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O43049
ORFeome ID
23/23B04
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 4184599..4186958 reverse strand

Annotation

PBO:0000610 - 3.1.3.16

GO biological process

GO:0007165 - signal transduction

References:

GO cellular component

GO:0005829 - cytosol

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GO:0005634 - nucleus

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GO molecular function

GO:0004722 - protein serine/threonine phosphatase activity

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Modification

MOD:01148 - ubiquitinylated lysine

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Protein features

PBO:0111755 - TPR repeat protein

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

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Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0009091 - decreased cell population growth on lysine and proline nitrogen source

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Genotypes:

FYPO:0007562 - decreased cell population growth on serine nitrogen source

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Genotypes:

FYPO:0000340 - haploinsufficient

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

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Genotypes:

FYPO:0007933 - sensitive to 2,2′-dipyridyl

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Genotypes:

FYPO:0001097 - sensitive to amitrole

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Genotypes:

FYPO:0000842 - sensitive to ethanol during vegetative growth

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Genotypes:

FYPO:0001719 - sensitive to lithium

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Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0001234 - slow vegetative cell population growth

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00149MetallophosCalcineurin-like_PHPPfam
PF08321PPP5PPP_domPfam
PF13181TPR_8TPR_rptPfam
cd07417MPP_PP5_CPP5_CCDD
PS00125SER_THR_PHOSPHATASESer/Thr-sp_prot-phosphatasePROSITE patterns
PS50005TPRTPR_rptPROSITE profiles
SM00028TPRTPR_rptSMART
SM00156PP2AcSer/Thr-sp_prot-phosphataseSMART
PR00114STPHPHTASESer/Thr-sp_prot-phosphatasePRINTS
G3DSA:3.60.21.10:FF:000039CATH-FunFam
G3DSA:1.25.40.10TPR-like_helical_dom_sfCATH-Gene3D
G3DSA:3.60.21.10Metallo-depent_PP-likeCATH-Gene3D
SSF48452TPR-like_helical_dom_sfSUPERFAMILY
SSF56300Metallo-depent_PP-likeSUPERFAMILY
PTHR45668PPP_phosphatasePANTHER
PIRSF033096PPPtase_5PIRSF

Orthologs

References / Literature

PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.
Roguev A et al. Science 2008 Oct 17;322(5900):405-10
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:18600047 - Genome-wide identification of haploinsufficiency in fission yeast.
Baek ST et al. J Microbiol Biotechnol 2008 Jun;18(6):1059-63
GO_REF:0000033 - Annotation inferences using phylogenetic trees