protein coding gene - trr1 (SPBC3F6.03) - thioredoxin reductase Trr1

Gene summary

Standard name

trr1

Systematic ID

SPBC3F6.03

Product

thioredoxin reductase Trr1

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

caf4, trxR

UniProt ID

Q92375

ORFeome ID

41/41H04

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 4189799..4191448 forward strand

Annotation

Protein features

Orthologs

• trr1 (SJAG_03653) Schizosaccharomyces japonicus
• TRR1 (YDR353W) Saccharomyces cerevisiae
• TRR2 (YHR106W) Saccharomyces cerevisiae

References / Literature

PMID:19625445 - Role for RACK1 orthologue Cpc2 in the modulation of stress response in fission yeast.

Núñez A et al. Mol Biol Cell 2009 Sep;20(18):3996-4009

PMID:26896847 - Ensembl comparative genomics resources.

Herrero J et al. Database (Oxford) 2016;2016

PMID:22279963 - Pap1p-dependent upregulation of thioredoxin 3 and thioredoxin reductase genes from the fission yeast under nitrosative stress.

Park MS et al. Can J Microbiol 2012 Feb;58(2):206-11

PMID:28640807 - Lack of a peroxiredoxin suppresses the lethality of cells devoid of electron donors by channelling electrons to oxidized ribonucleotide reductase.

Boronat S et al. PLoS Genet 2017 Jun;13(6):e1006858

PMID:36174923 - Schizosaccharomyces pombe MAP kinase Sty1 promotes survival of Δppr10 cells with defective mitochondrial protein synthesis.

Hu Y et al. Int J Biochem Cell Biol 2022 Nov;152:106308

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:10428959 - Sin1: an evolutionarily conserved component of the eukaryotic SAPK pathway.

Wilkinson MG et al. EMBO J 1999 Aug 02;18(15):4210-21

PMID:24521463 - A genetic approach to study H2O2 scavenging in fission yeast--distinct roles of peroxiredoxin and catalase.

Paulo E et al. Mol Microbiol 2014 Apr;92(2):246-57

PMID:18758731 - The role and regulation of Trxl, a cytosolic thioredoxin in Schizosaccharomyces pombe.

Song JY et al. J Microbiol 2008 Aug;46(4):408-14

PMID:23115244 - Cells lacking pfh1, a fission yeast homolog of mammalian frataxin protein, display constitutive activation of the iron starvation response.

Gabrielli N et al. J Biol Chem 2012 Dec 14;287(51):43042-51

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:16554715 - Transcriptional analysis and pap1-dependence of the unique gene encoding thioredoxin reductase from the fission yeast.

Kang HJ et al. J Microbiol 2006 Feb;44(1):35-41

PMID:10348908 - A fission yeast gene (prr1(+)) that encodes a response regulator implicated in oxidative stress response.

Ohmiya R et al. J Biochem 1999 Jun;125(6):1061-6

PMID:24118096 - Methionine sulphoxide reductases revisited: free methionine as a primary target of H₂O₂stress in auxotrophic fission yeast.

García-Santamarina S et al. Mol Microbiol 2013 Dec;90(5):1113-24

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:17409354 - The peroxiredoxin Tpx1 is essential as a H2O2 scavenger during aerobic growth in fission yeast.

Jara M et al. Mol Biol Cell 2007 Jun;18(6):2288-95

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:22344694 - The transcription factors Pap1 and Prr1 collaborate to activate antioxidant, but not drug tolerance, genes in response to H2O2.

Calvo IA et al. Nucleic Acids Res 2012 Jun;40(11):4816-24

PMID:23525001 - Reversible thiol oxidation in the H2O2-dependent activation of the transcription factor Pap1.

Calvo IA et al. J Cell Sci 2013 May 15;126(Pt 10):2279-84

PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.

Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31

PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.

Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85

GO_REF:0000002 - Comments

PMID:20919928 - Two-component mediated peroxide sensing and signal transduction in fission yeast.

Quinn J et al. Antioxid Redox Signal 2011 Jul 01;15(1):153-65

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:12100563 - Diethylmaleate activates the transcription factor Pap1 by covalent modification of critical cysteine residues.

Castillo EA et al. Mol Microbiol 2002 Jul;45(1):243-54

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:9211790 - Caffeine-resistance in S. pombe: mutations in three novel caf genes increase caffeine tolerance and affect radiation sensitivity, fertility, and cell cycle.

Benko Z et al. Curr Genet 1997 Jun;31(6):481-7

PMID:9585505 - Regulation of the fission yeast transcription factor Pap1 by oxidative stress: requirement for the nuclear export factor Crm1 (Exportin) and the stress-activated MAP kinase Sty1/Spc1.

Toone WM et al. Genes Dev 1998 May 15;12(10):1453-63

PMID:11071922 - A fission yeast homolog of Int-6, the mammalian oncoprotein and eIF3 subunit, induces drug resistance when overexpressed.

Crane R et al. Mol Biol Cell 2000 Nov;11(11):3993-4003

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:18235227 - Fission yeast TOR complex 2 activates the AGC-family Gad8 kinase essential for stress resistance and cell cycle control.

Ikeda K et al. Cell Cycle 2008 Feb 01;7(3):358-64

PMID:14758541 - The transcription factor Pap1/Caf3 plays a central role in the determination of caffeine resistance in Schizosaccharomyces pombe.

Benko Z et al. Mol Genet Genomics 2004 Mar;271(2):161-70

PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Lee J et al. Nat Commun 2017 Feb 20;8:14527

PMID:11179424 - Peroxide sensors for the fission yeast stress-activated mitogen-activated protein kinase pathway.

Buck V et al. Mol Biol Cell 2001 Feb;12(2):407-19

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:18257517 - Phosphoproteome analysis of fission yeast.

Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97

PMID:19672306 - Genome-wide screen of genes required for caffeine tolerance in fission yeast.

Calvo IA et al. PLoS One 2009 Aug 12;4(8):e6619

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:23695164 - Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.

Das J et al. Sci Signal 2013 May 21;6(276):ra38

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:26152728 - A Two-step Protein Quality Control Pathway for a Misfolded DJ-1 Variant in Fission Yeast.

Mathiassen SG et al. J Biol Chem 2015 Aug 21;290(34):21141-21153

PMID:16141205 - The glycolytic metabolite methylglyoxal activates Pap1 and Sty1 stress responses in Schizosaccharomyces pombe.

Zuin A et al. J Biol Chem 2005 Nov 04;280(44):36708-13

PMID:12529438 - Global transcriptional responses of fission yeast to environmental stress.

Chen D et al. Mol Biol Cell 2003 Jan;14(1):214-29

PMID:23121505 - Is oxidized thioredoxin a major trigger for cysteine oxidation? Clues from a redox proteomics approach.

García-Santamarina S et al. Antioxid Redox Signal 2013 May 01;18(13):1549-56

PMID:15135546 - Stress-dependent regulation of the gene encoding thioredoxin reductase from the fission yeast.

Hong SM et al. FEMS Microbiol Lett 2004 May 15;234(2):379-85

PMID:28652406 - Deciphering the role of the signal- and Sty1 kinase-dependent phosphorylation of the stress-responsive transcription factor Atf1 on gene activation.

Salat-Canela C et al. J Biol Chem 2017 Aug 18;292(33):13635-13644

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.

UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531

PMID:9894913 - Cloning of caf1+, caf2+ and caf4+ from Schizosaccharomyces pombe: their involvement in multidrug resistance, UV and pH sensitivity.

Benko Z et al. Mol Gen Genet 1998 Dec;260(5):434-43

PMID:10628977 - Isolation and characterization of Nrf1p, a novel negative regulator of the Cdc42p GTPase in Schizosaccharomyces pombe.

Murray JM et al. Genetics 2000 Jan;154(1):155-65

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:24268782 - A peroxiredoxin promotes H2O2 signaling and oxidative stress resistance by oxidizing a thioredoxin family protein.

Brown JD et al. Cell Rep 2013 Dec 12;5(5):1425-35