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protein coding gene - pof9 (SPBC3H7.06c) - F-box protein Pof9

Gene summary

Standard name
pof9
Systematic ID
SPBC3H7.06c
Product
F-box protein Pof9
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O74381
ORFeome ID
23/23G08
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 1871833..1873320 forward strand

Annotation

GO biological process

GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

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GO cellular component

GO:0005829 - cytosol

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GO:0005634 - nucleus

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GO:0000151 - ubiquitin ligase complex

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GO molecular function

GO:0005515 - protein binding

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GO:1990756 - ubiquitin-like ligase-substrate adaptor activity

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Protein features

PBO:0111823 - F-box protein

PBO:0111820 - regulator of condensation (RCC1) domains

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0009072 - increased cell population growth on lysine nitrogen source

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Genotypes:

FYPO:0000763 - resistance to cadmium

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0002578 - resistance to hydroxyurea

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Genotypes:

FYPO:0001583 - resistance to lithium

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Genotypes:

FYPO:0009083 - resistance to lithium chloride and methyl methanesulfonate

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Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0000830 - resistance to vanadate

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011063 - conserved in fungi only

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00646F-boxF-box_domPFAM
PS50012RCC1_3Reg_chr_condensPROSITE_PROFILES
PS50181FBOXF-box_domPROSITE_PROFILES
SM00256fbox_2F-box_domSMART
SSF50985RCC1/BLIP-IIRCC1/BLIP-IISUPERFAMILY
SSF81383F-box domainF-box-like_dom_sfSUPERFAMILY
G3DSA:1.20.1280.50GENE3D
G3DSA:2.130.10.30RCC1/BLIP-IIGENE3D
PTHR45982REGULATOR OF CHROMOSOME CONDENSATIONRan_GTPase-activatingPANTHER

Orthologs

References / Literature

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.
Roguev A et al. Science 2008 Oct 17;322(5900):405-10
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:19748355 - F-box-directed CRL complex assembly and regulation by the CSN and CAND1.
Schmidt MW et al. Mol Cell 2009 Sep 11;35(5):586-97
PMID:23535663 - CAND1 controls in vivo dynamics of the cullin 1-RING ubiquitin ligase repertoire.
Wu S et al. Nat Commun 2013;4:1642
PMID:21981922 - A Pre-mRNA degradation pathway that selectively targets intron-containing genes requires the nuclear poly(A)-binding protein.
Lemieux C et al. Mol Cell 2011 Oct 07;44(1):108-19
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:15147268 - Molecular interactions of fission yeast Skp1 and its role in the DNA damage checkpoint.
Lehmann A et al. Genes Cells 2004 May;9(5):367-82
PMID:19430462 - Decapping is preceded by 3' uridylation in a novel pathway of bulk mRNA turnover.
Rissland OS et al. Nat Struct Mol Biol 2009 Jun;16(6):616-23
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:16615890 - Meiotic proteins bqt1 and bqt2 tether telomeres to form the bouquet arrangement of chromosomes.
Chikashige Y et al. Cell 2006 Apr 07;125(1):59-69
GO_REF:0000050 - Manual transfer of GO annotation data to genes by curator judgment of sequence model
PMID:18931302 - Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes.
Dixon SJ et al. Proc Natl Acad Sci U S A 2008 Oct 28;105(43):16653-8
PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.
Paulo JA et al. J Proteomics 2020 Jan 06;210:103531