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protein coding gene - trm141 (SPBC3H7.11) - tRNA(Ser) residue 32 (cytosine-3-)-methyltransferase Trm141

Gene summary

Standard name
trm141
Systematic ID
SPBC3H7.11
Product
tRNA(Ser) residue 32 (cytosine-3-)-methyltransferase Trm141
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
abp140
UniProt ID
O74386
ORFeome ID
10/10E08
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 1863284..1864441 reverse strand

Annotation

GO biological process

GO:0106217 - tRNA C3-cytosine methylation

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GO cellular component

GO:0005829 - cytosol

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GO:0005634 - nucleus

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GO molecular function

GO:0052735 - tRNA (cytidine-N3)-methyltransferase activity

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Modification

MOD:01148 - ubiquitinylated lysine

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Qualitative gene expression

PomGeneEx:0000027 - ribosomal density decreased

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PomGeneEx:0000012 - RNA level decreased

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0002019 - elongated telomeres during vegetative growth

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Genotypes:

FYPO:0002693 - resistance to diamide

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Genotypes:

FYPO:0001583 - resistance to lithium

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Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0000096 - sensitive to cadmium

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Genotypes:

FYPO:0009088 - sensitive to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0000271 - sensitive to salt stress

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0012033 - tandem fusion protein in S. cerevisiae, SPBC3H7.11 is related to the N-terminal region of YOR239W

Protein features

IDNameInterPro nameDB name
PF08242Methyltransf_12Methyltransf_12PFAM
cd02440AdoMet_MTasesCDD
G3DSA:3.40.50.150:FF:000279FUNFAM
SSF53335S-adenosyl-L-methionine-dependent methyltransferasesSAM-dependent_MTases_sfSUPERFAMILY
G3DSA:3.40.50.150Vaccinia Virus protein VP39SAM-dependent_MTases_sfGENE3D
PTHR22809METHYLTRANSFERASE-RELATEDMETTL2/6/8-likePANTHER
PIRSF037755Mettl2METTL2/6/8-likePIRSF

Orthologs

References / Literature

PMID:20625380 - A genome-wide screen for Schizosaccharomyces pombe deletion mutants that affect telomere length.
Liu NN et al. Cell Res 2010 Aug;20(8):963-5
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:18684775 - A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe.
Kennedy PJ et al. Toxicol Sci 2008 Nov;106(1):124-39
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:27354703 - Evolving specificity of tRNA 3-methyl-cytidine-32 (m3C32) modification: a subset of tRNAsSer requires N6-isopentenylation of A37.
Arimbasseri AG et al. RNA 2016 Sep;22(9):1400-10
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704