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protein coding gene - dni2 (SPBC4.01) - meiotic tetraspan protein, claudin Dni2

Gene summary

Standard name
dni2
Systematic ID
SPBC4.01
Product
meiotic tetraspan protein, claudin Dni2
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9USS9
ORFeome ID
12/12C07
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 1184427..1185324 forward strand

Annotation

GO biological process

GO:0000755 - cytogamy

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GO cellular component

GO:0005783 - endoplasmic reticulum

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GO:1990819 - mating projection actin fusion focus

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GO:0043332 - mating projection tip

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GO:0070867 - mating projection tip membrane

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Multi-locus phenotype

FYPO:0000584 - decreased sporulation frequency

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Genotypes:

FYPO:0004181 - normal protein localization to cell-cell contact point during mating

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Genotypes:

FYPO:0002052 - normal sporulation frequency

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Genotypes:

Protein sequence feature

SO:0000418 - signal_peptide

SO:0001812 - transmembrane_helix

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Qualitative gene expression

PomGeneEx:0000018 - protein level increased

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PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0006586 - abolished protein localization to shmoo tip membrane, with protein distributed in plasma membrane

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Genotypes:

FYPO:0006585 - abolished protein localization to shmoo tip membrane, with protein mislocalized to endoplasmic reticulum

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Genotypes:

FYPO:0000708 - decreased mating efficiency

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Genotypes:

FYPO:0006541 - decreased protein level during mating

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Genotypes:

FYPO:0006587 - decreased protein localization to shmoo tip membrane

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Genotypes:

FYPO:0001645 - decreased protein-protein interaction

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Genotypes:

FYPO:0001571 - increased protein-protein interaction

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011063 - conserved in fungi only

Orthologs

References / Literature

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:21504829 - Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.
Stewart EV et al. Mol Cell 2011 Apr 22;42(2):160-71
PMID:33109728 - High-Throughput Identification of Nuclear Envelope Protein Interactions in Schizosaccharomyces pombe Using an Arrayed Membrane Yeast-Two Hybrid Library.
Varberg JM et al. G3 (Bethesda) 2020 Dec 03;10(12):4649-4663
PMID:24514900 - Membrane organization and cell fusion during mating in fission yeast requires multipass membrane protein Prm1.
Curto MÁ et al. Genetics 2014 Apr;196(4):1059-76
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.
Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:29134248 - The ancient claudin Dni2 facilitates yeast cell fusion by compartmentalizing Dni1 into a membrane subdomain.
Curto MÁ et al. Cell Mol Life Sci 2018 May;75(9):1687-1706
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:41335110 - High-resolution mapping of the actin fusion focus reveals myosin V-dependent formin transport for aster formation.
Thomas V et al. J Cell Biol 2026 Feb 02;225(2)