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protein coding gene - sfb3 (SPBC4.03c) - COPII-coated vesicle component Sfb3

Gene summary

Standard name
sfb3
Systematic ID
SPBC4.03c
Product
COPII-coated vesicle component Sfb3
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9USS7
ORFeome ID
38/38H07
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 1187646..1190821 reverse strand

Annotation

Disease association

MONDO:0014573 - Cole-Carpenter syndrome 2

References:

GO biological process

GO:0090110 - COPII-coated vesicle cargo loading

References:

GO:0006886 - intracellular protein transport

References:

GO cellular component

GO:0030127 - COPII vesicle coat

References:

GO:0005829 - cytosol

References:

GO:0070971 - endoplasmic reticulum exit site

References:

GO molecular function

GO:0000149 - SNARE binding

References:

GO:0008270 - zinc ion binding

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

References:

MOD:01148 - ubiquitinylated lysine

References:

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0006926 - increased nucleus:cytoplasm ratio

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0001511 - inviable vegetative cell, abnormal cell shape, normal cell size

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF04811Sec23_trunkSec23/24_trunk_domPFAM
PF04815Sec23_helicalSec23/24_helical_domPFAM
PF00626GelsolinGelsolin-like_domPFAM
PF08033Sec23_BSBeta-sandwich_Sec23_24PFAM
PF04810zf-Sec23_Sec24Znf_Sec23_Sec24PFAM
cd01479Sec24-likeSec24-like_trunk_domCDD
G3DSA:3.40.50.410:FF:000020FUNFAM
SSF53300vWA-likevWFA_dom_sfSUPERFAMILY
SSF82919Zn-finger domain of Sec23/24Znf_Sec23_Sec24_sfSUPERFAMILY
SSF81811Helical domain of Sec23/24Sec23/24_helical_dom_sfSUPERFAMILY
SSF82754C-terminal, gelsolin-like domain of Sec23/24Gelsolin-like_dom_sfSUPERFAMILY
SSF81995beta-sandwich domain of Sec23/24SUPERFAMILY
G3DSA:1.20.120.730Sec23/Sec24 helical domainGENE3D
G3DSA:2.60.40.1670GENE3D
G3DSA:2.30.30.380GENE3D
G3DSA:3.40.20.10SeverinADF-H/Gelsolin-like_dom_sfGENE3D
G3DSA:3.40.50.410von Willebrand factor, type A domainvWFA_dom_sfGENE3D
PTHR13803SEC24-RELATED PROTEINSEC23_SEC24_subfamilyPANTHER

Orthologs

References / Literature

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
GO_REF:0000002 - Comments
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:22730331 - Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions.
Nie M et al. J Biol Chem 2012 Aug 24;287(35):29610-9
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:30759079 - A systematic genetic screen identifies essential factors involved in nuclear size control.
Cantwell H et al. PLoS Genet 2019 Feb;15(2):e1007929
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87