protein coding gene - mis12 (SPBC409.04c) - MIS12/MIND complex Mis12

Gene summary

Standard name

mis12

Systematic ID

SPBC409.04c

Product

MIS12/MIND complex Mis12

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

Q9Y738

ORFeome ID

09/09G06

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 1137753..1139618 reverse strand

Annotation

Protein features

Orthologs

• MIS12 (HGNC:24967) Homo sapiens
• mis12 (SJAG_03220) Schizosaccharomyces japonicus
• MTW1 (YAL034W-A) Saccharomyces cerevisiae

References / Literature

PMID:16920624 - CDC2 phosphorylation of the fission yeast dis1 ensures accurate chromosome segregation.

Aoki K et al. Curr Biol 2006 Aug 22;16(16):1627-35

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:10398680 - Proper metaphase spindle length is determined by centromere proteins Mis12 and Mis6 required for faithful chromosome segregation.

Goshima G et al. Genes Dev 1999 Jul 01;13(13):1664-77

PMID:15369671 - Mis16 and Mis18 are required for CENP-A loading and histone deacetylation at centromeres.

Hayashi T et al. Cell 2004 Sep 17;118(6):715-29

PMID:26483559 - Nup132 modulates meiotic spindle attachment in fission yeast by regulating kinetochore assembly.

Yang HJ et al. J Cell Biol 2015 Oct 26;211(2):295-308

PMID:26581324 - Cleavage and polyadenylation factor, Rna14 is an essential protein required for the maintenance of genomic integrity in fission yeast Schizosaccharomyces pombe.

Sonkar A et al. Biochim Biophys Acta 2016 Feb;1863(2):189-97

PMID:36537249 - The fission yeast kinetochore complex Mhf1-Mhf2 regulates the spindle assembly checkpoint and faithful chromosome segregation.

Jian Y et al. J Cell Sci 2023 Jan 15;136(2)

PMID:17627824 - The kinetochore proteins Pcs1 and Mde4 and heterochromatin are required to prevent merotelic orientation.

Gregan J et al. Curr Biol 2007 Jul 17;17(14):1190-200

PMID:15502821 - A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1.

Obuse C et al. Nat Cell Biol 2004 Nov;6(11):1135-41

PMID:29899117 - Ccp1 modulates epigenetic stability at centromeres and affects heterochromatin distribution in Schizosaccharomyces pombe .

Lu M et al. J Biol Chem 2018 Aug 03;293(31):12068-12080

PMID:17352737 - The fission yeast DASH complex is essential for satisfying the spindle assembly checkpoint induced by defects in the inner-kinetochore proteins.

Kobayashi Y et al. Genes Cells 2007 Mar;12(3):311-28

PMID:29180432 - Phosphorylation of CENP-C by Aurora B facilitates kinetochore attachment error correction in mitosis.

Zhou X et al. Proc Natl Acad Sci U S A 2017 Dec 12;114(50):E10667-E10676

GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:12773390 - The role of Ppe1/PP6 phosphatase for equal chromosome segregation in fission yeast kinetochore.

Goshima G et al. EMBO J 2003 Jun 02;22(11):2752-63

PMID:26900649 - The hairpin region of Ndc80 is important for the kinetochore recruitment of Mph1/MPS1 in fission yeast.

Chmielewska AE et al. Cell Cycle 2016;15(5):740-7

PMID:12242294 - The mal2p protein is an essential component of the fission yeast centromere.

Jin QW et al. Mol Cell Biol 2002 Oct;22(20):7168-83

PMID:17035632 - Reconstruction of the kinetochore during meiosis in fission yeast Schizosaccharomyces pombe.

Hayashi A et al. Mol Biol Cell 2006 Dec;17(12):5173-84

PMID:17004072 - Chromosome segregation in fission yeast with mutations in the tubulin folding cofactor D.

Fedyanina OS et al. Curr Genet 2006 Nov;50(5):281-94

PMID:12535531 - A cell cycle-regulated GATA factor promotes centromeric localization of CENP-A in fission yeast.

Chen ES et al. Mol Cell 2003 Jan;11(1):175-87

PMID:12719471 - Sim4: a novel fission yeast kinetochore protein required for centromeric silencing and chromosome segregation.

Pidoux AL et al. J Cell Biol 2003 Apr 28;161(2):295-307

PMID:16914721 - Upf1, an RNA helicase required for nonsense-mediated mRNA decay, modulates the transcriptional response to oxidative stress in fission yeast.

Rodríguez-Gabriel MA et al. Mol Cell Biol 2006 Sep;26(17):6347-56

PMID:21445296 - Mis17 is a regulatory module of the Mis6-Mal2-Sim4 centromere complex that is required for the recruitment of CenH3/CENP-A in fission yeast.

Shiroiwa Y et al. PLoS One 2011 Mar 21;6(3):e17761

PMID:31618856 - Two XMAP215/TOG Microtubule Polymerases, Alp14 and Dis1, Play Non-Exchangeable, Distinct Roles in Microtubule Organisation in Fission Yeast.

Yukawa M et al. Int J Mol Sci 2019 Oct 15;20(20)

PMID:36478272 - Translation-complex profiling of fission yeast cells reveals dynamic rearrangements of scanning ribosomal subunits upon nutritional stress.

Duncan CDS et al. Nucleic Acids Res 2022 Dec 09;50(22):13011-13025

PMID:16079914 - Molecular analysis of kinetochore architecture in fission yeast.

Liu X et al. EMBO J 2005 Aug 17;24(16):2919-30

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:16079915 - The DASH complex and Klp5/Klp6 kinesin coordinate bipolar chromosome attachment in fission yeast.

Sanchez-Perez I et al. EMBO J 2005 Aug 17;24(16):2931-43

PMID:19217403 - Fission yeast Scm3 mediates stable assembly of Cnp1/CENP-A into centromeric chromatin.

Williams JS et al. Mol Cell 2009 Feb 13;33(3):287-98

GO_REF:0000002 - Comments

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:23091701 - Impaired coenzyme A synthesis in fission yeast causes defective mitosis, quiescence-exit failure, histone hypoacetylation and fragile DNA.

Nakamura T et al. Open Biol 2012 Sep;2(9):120117

PMID:36705602 - Unraveling the kinetochore nanostructure in Schizosaccharomyces pombe using multi-color SMLM imaging.

Virant D et al. J Cell Biol 2023 Apr 03;222(4)

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:11369198 - M phase-specific kinetochore proteins in fission yeast: microtubule-associating Dis1 and Mtc1 display rapid separation and segregation during anaphase.

Nakaseko Y et al. Curr Biol 2001 Apr 17;11(8):537-49

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:10864871 - Requirement of Mis6 centromere connector for localizing a CENP-A-like protein in fission yeast.

Takahashi K et al. Science 2000 Jun 23;288(5474):2215-9

PMID:24477934 - Mad1 contribution to spindle assembly checkpoint signalling goes beyond presenting Mad2 at kinetochores.

Heinrich S et al. EMBO Rep 2014 Mar;15(3):291-8

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:35970865 - The Mis6 inner kinetochore subcomplex maintains CENP-A nucleosomes against centromeric non-coding transcription during mitosis.

Hirai H et al. Commun Biol 2022 Aug 15;5(1):818

PMID:31474649 - Identification of 15 New Bypassable Essential Genes of Fission Yeast.

Takeda A et al. Cell Struct Funct 2019 Sep 27;44(2):113-119

PMID:17442892 - The conserved Spc7 protein is required for spindle integrity and links kinetochore complexes in fission yeast.

Kerres A et al. Mol Biol Cell 2007 Jul;18(7):2441-54

PMID:22711988 - Sos7, an essential component of the conserved Schizosaccharomyces pombe Ndc80-MIND-Spc7 complex, identifies a new family of fungal kinetochore proteins.

Jakopec V et al. Mol Cell Biol 2012 Aug;32(16):3308-20

PMID:21324894 - Nuclear protein quality is regulated by the ubiquitin-proteasome system through the activity of Ubc4 and San1 in fission yeast.

Matsuo Y et al. J Biol Chem 2011 Apr 15;286(15):13775-90

PMID:28974540 - The fission yeast nucleoporin Alm1 is required for proteasomal degradation of kinetochore components.

Salas-Pino S et al. J Cell Biol 2017 Nov 06;216(11):3591-3608

PMID:7865880 - Fission yeast minichromosome loss mutants mis cause lethal aneuploidy and replication abnormality.

Takahashi K et al. Mol Biol Cell 1994 Oct;5(10):1145-58

PMID:18362178 - Dissection of the essential steps for condensin accumulation at kinetochores and rDNAs during fission yeast mitosis.

Nakazawa N et al. J Cell Biol 2008 Mar 24;180(6):1115-31

PMID:15930132 - Spindle checkpoint signaling requires the mis6 kinetochore subcomplex, which interacts with mad2 and mitotic spindles.

Saitoh S et al. Mol Biol Cell 2005 Aug;16(8):3666-77

PMID:23028377 - Factors that promote H3 chromatin integrity during transcription prevent promiscuous deposition of CENP-A(Cnp1) in fission yeast.

Choi ES et al. PLoS Genet 2012 Sep;8(9):e1002985

PMID:24774534 - Schizosaccharomyces pombe centromere protein Mis19 links Mis16 and Mis18 to recruit CENP-A through interacting with NMD factors and the SWI/SNF complex.

Hayashi T et al. Genes Cells 2014 Jul;19(7):541-54

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:34849791 - Perturbation of kinetochore function using GFP-binding protein in fission yeast.

Deng DJ et al. G3 (Bethesda) 2021 Oct 19;11(11)

PMID:15728720 - Dissociation of the Nuf2-Ndc80 complex releases centromeres from the spindle-pole body during meiotic prophase in fission yeast.

Asakawa H et al. Mol Biol Cell 2005 May;16(5):2325-38

PMID:23166349 - Csi1 links centromeres to the nuclear envelope for centromere clustering.

Hou H et al. J Cell Biol 2012 Nov 26;199(5):735-44

PMID:17947424 - Msc1 acts through histone H2A.Z to promote chromosome stability in Schizosaccharomyces pombe.

Ahmed S et al. Genetics 2007 Nov;177(3):1487-97

PMID:16688222 - Histone H2B mutations in inner region affect ubiquitination, centromere function, silencing and chromosome segregation.

Maruyama T et al. EMBO J 2006 Jun 07;25(11):2420-31