protein coding gene - wis1 (SPBC409.07c) - MAP kinase kinase Wis1

Gene summary

Standard name

wis1

Systematic ID

SPBC409.07c

Product

MAP kinase kinase Wis1

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

spc2, smf2, sty2

UniProt ID

P33886

ORFeome ID

33/33D12

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 1143731..1146603 reverse strand

Annotation

Protein features

Orthologs

• MAP2K1 (HGNC:6840) Homo sapiens
• MAP2K2 (HGNC:6842) Homo sapiens
• wis1 (SJAG_02342) Schizosaccharomyces japonicus
• PBS2 (YJL128C) Saccharomyces cerevisiae

References / Literature

PMID:15821139 - Systematic deletion analysis of fission yeast protein kinases.

Bimbó A et al. Eukaryot Cell 2005 Apr;4(4):799-813

PMID:1588914 - Five novel elements involved in the regulation of mitosis in fission yeast.

Warbrick E et al. Mol Gen Genet 1992 Apr;232(3):440-6

PMID:17952063 - TOR signalling regulates mitotic commitment through the stress MAP kinase pathway and the Polo and Cdc2 kinases.

Petersen J et al. Nat Cell Biol 2007 Nov;9(11):1263-72

PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Lee J et al. Nat Commun 2017 Feb 20;8:14527

PMID:20075862 - Lifespan extension by calorie restriction relies on the Sty1 MAP kinase stress pathway.

Zuin A et al. EMBO J 2010 Mar 03;29(5):981-91

PMID:9135147 - Spm1, a stress-activated MAP kinase that regulates morphogenesis in S.pombe.

Zaitsevskaya-Carter T et al. EMBO J 1997 Mar 17;16(6):1318-31

PMID:22912829 - Response to arsenate treatment in Schizosaccharomyces pombe and the role of its arsenate reductase activity.

Salgado A et al. PLoS One 2012;7(8):e43208

PMID:26443240 - PKA antagonizes CLASP-dependent microtubule stabilization to re-localize Pom1 and buffer cell size upon glucose limitation.

Kelkar M et al. Nat Commun 2015 Oct 07;6:8445

PMID:9974219 - Enhancement of neutral trehalase activity by oxidative stress in the fission yeast Schizosaccharomyces pombe.

Fernández J et al. Fungal Genet Biol 1998 Nov;25(2):79-86

PMID:10749922 - Multistep phosphorelay proteins transmit oxidative stress signals to the fission yeast stress-activated protein kinase.

Nguyen AN et al. Mol Biol Cell 2000 Apr;11(4):1169-81

PMID:9135083 - Schizosaccharomyces pombe gad7+ encodes a phosphoprotein with a bZIP domain, which is required for proper G1 arrest and gene expression under nitrogen starvation.

Kanoh J et al. Genes Cells 1996 Apr;1(4):391-408

PMID:9614178 - Heat stress activates fission yeast Spc1/StyI MAPK by a MEKK-independent mechanism.

Shiozaki K et al. Mol Biol Cell 1998 Jun;9(6):1339-49

PMID:15870269 - Response of fission yeast to toxic cations involves cooperative action of the stress-activated protein kinase Spc1/Sty1 and the Hal4 protein kinase.

Wang LY et al. Mol Cell Biol 2005 May;25(10):3945-55

PMID:9199286 - Mkh1, a MEK kinase required for cell wall integrity and proper response to osmotic and temperature stress in Schizosaccharomyces pombe.

Sengar AS et al. Mol Cell Biol 1997 Jul;17(7):3508-19

PMID:31911490 - RNA-Binding Protein Rnc1 Regulates Cell Length at Division and Acute Stress Response in Fission Yeast through Negative Feedback Modulation of the Stress-Activated Mitogen-Activated Protein Kinase Pathway.

Prieto-Ruiz F et al. mBio 2020 Jan 07;11(1)

PMID:16087744 - Distinct signaling pathways respond to arsenite and reactive oxygen species in Schizosaccharomyces pombe.

Rodríguez-Gabriel MA et al. Eukaryot Cell 2005 Aug;4(8):1396-402

PMID:10398679 - Heat-shock-induced activation of stress MAP kinase is regulated by threonine- and tyrosine-specific phosphatases.

Nguyen AN et al. Genes Dev 1999 Jul 01;13(13):1653-63

PMID:11872168 - Genes for a nuclease and a protease are involved in the drastic decrease in cellular RNA amount in fission yeast cells during nitrogen starvation.

Nakashima A et al. J Biochem 2002 Mar;131(3):391-8

PMID:9671458 - An RNA binding protein negatively controlling differentiation in fission yeast.

Tsukahara K et al. Mol Cell Biol 1998 Aug;18(8):4488-98

PMID:11238405 - Transcriptional regulators of the Schizosaccharomyces pombe fbp1 gene include two redundant Tup1p-like corepressors and the CCAAT binding factor activation complex.

Janoo RT et al. Genetics 2001 Mar;157(3):1205-15

PMID:16550352 - A starvation-specific serine protease gene, isp6+, is involved in both autophagy and sexual development in Schizosaccharomyces pombe.

Nakashima A et al. Curr Genet 2006 Jun;49(6):403-13

PMID:15917811 - Polo kinase links the stress pathway to cell cycle control and tip growth in fission yeast.

Petersen J et al. Nature 2005 May 26;435(7041):507-12

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:20501954 - Search for kinases related to transition of growth polarity in fission yeast.

Koyano T et al. Biosci Biotechnol Biochem 2010;74(5):1129-33

PMID:22084378 - Nutrient limitations alter cell division control and chromosome segregation through growth-related kinases and phosphatases.

Yanagida M et al. Philos Trans R Soc Lond B Biol Sci 2011 Dec 27;366(1584):3508-20

PMID:26432170 - Distinct biological activity of threonine monophosphorylated MAPK isoforms during the stress response in fission yeast.

Vázquez B et al. Cell Signal 2015 Dec;27(12):2534-42

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:32915139 - Stress-activated MAPK signaling controls fission yeast actomyosin ring integrity by modulating formin For3 levels.

Gómez-Gil E et al. Elife 2020 Sep 11;9

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134

PMID:10526174 - Functional complementation of the Schizosaccharomyces pombe wis1 mutant by Arabidopsis MEK1 and non-catalytic enhancement by CTR1.

Pan Z et al. FEBS Lett 1999 Oct 15;459(3):405-10

PMID:22144909 - The fission yeast stress-responsive MAPK pathway promotes meiosis via the phosphorylation of Pol II CTD in response to environmental and feedback cues.

Sukegawa Y et al. PLoS Genet 2011 Dec;7(12):e1002387

PMID:27746023 - Remodeling of the Fission Yeast Cdc42 Cell-Polarity Module via the Sty1 p38 Stress-Activated Protein Kinase Pathway.

Mutavchiev DR et al. Curr Biol 2016 Nov 07;26(21):2921-2928

PMID:8649397 - Activation and regulation of the Spc1 stress-activated protein kinase in Schizosaccharomyces pombe.

Degols G et al. Mol Cell Biol 1996 Jun;16(6):2870-7

PMID:19672306 - Genome-wide screen of genes required for caffeine tolerance in fission yeast.

Calvo IA et al. PLoS One 2009 Aug 12;4(8):e6619

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:9443913 - Regulated vacuole fusion and fission in Schizosaccharomyces pombe: an osmotic response dependent on MAP kinases.

Bone N et al. Curr Biol 1998 Jan 29;8(3):135-44

PMID:12861001 - Identification of Cdc37 as a novel regulator of the stress-responsive mitogen-activated protein kinase.

Tatebe H et al. Mol Cell Biol 2003 Aug;23(15):5132-42

PMID:22139357 - H₂O₂ stress-specific regulation of S. pombe MAPK Sty1 by mitochondrial protein phosphatase Ptc4.

Di Y et al. EMBO J 2012 Feb 01;31(3):563-75

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:16861909 - Fission yeast MAP kinase is required for the increased securin-separase interaction that rescues separase mutants under stresses.

Kawasaki Y et al. Cell Cycle 2006 Aug;5(16):1831-9

PMID:9585505 - Regulation of the fission yeast transcription factor Pap1 by oxidative stress: requirement for the nuclear export factor Crm1 (Exportin) and the stress-activated MAP kinase Sty1/Spc1.

Toone WM et al. Genes Dev 1998 May 15;12(10):1453-63

PMID:10428498 - The cta3+ gene that encodes a cation-transporting P-type ATPase is induced by salt stress under control of the Wis1-Sty1 MAPKK-MAPK cascade in fission yeast.

Nishikawa T et al. FEBS Lett 1999 Jul 16;455(1-2):183-7

PMID:9154834 - Discrete roles of the Spc1 kinase and the Atf1 transcription factor in the UV response of Schizosaccharomyces pombe.

Degols G et al. Mol Cell Biol 1997 Jun;17(6):3356-63

PMID:19625445 - Role for RACK1 orthologue Cpc2 in the modulation of stress response in fission yeast.

Núñez A et al. Mol Biol Cell 2009 Sep;20(18):3996-4009

PMID:21340088 - Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.

Arita Y et al. Mol Biosyst 2011 May;7(5):1463-72

PMID:20974849 - Fission yeast receptor of activated C kinase (RACK1) ortholog Cpc2 regulates mitotic commitment through Wee1 kinase.

Núñez A et al. J Biol Chem 2010 Dec 31;285(53):41366-73

PMID:22661707 - A measurable activation of the bZIP transcription factor Atf1 in a fission yeast strain devoid of stress-activated and cell integrity mitogen-activated protein kinase (MAPK) activities.

Zhou X et al. J Biol Chem 2012 Jul 06;287(28):23434-9

PMID:7657164 - Pyp1 and Pyp2 PTPases dephosphorylate an osmosensing MAP kinase controlling cell size at division in fission yeast.

Millar JB et al. Genes Dev 1995 Sep 01;9(17):2117-30

PMID:19037094 - The Rho1p exchange factor Rgf1p signals upstream from the Pmk1 mitogen-activated protein kinase pathway in fission yeast.

Garcia P et al. Mol Biol Cell 2009 Jan;20(2):721-31

PMID:29900664 - Tschimganine and its derivatives extend the chronological life span of yeast via activation of the Sty1 pathway.

Hibi T et al. Genes Cells 2018 Jun 14;

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:8832415 - The wis1 signal transduction pathway is required for expression of cAMP-repressed genes in fission yeast.

Stettler S et al. J Cell Sci 1996 Jul;109 ( Pt 7):1927-35

PMID:7501024 - Cell-cycle control linked to extracellular environment by MAP kinase pathway in fission yeast.

Shiozaki K et al. Nature 1995 Dec 14;378(6558):739-43

PMID:27984725 - CDK Substrate Phosphorylation and Ordering the Cell Cycle.

Swaffer MP et al. Cell 2016 Dec 15;167(7):1750-1761.e16

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:22806344 - Genome-wide screen reveals novel mechanisms for regulating cobalt uptake and detoxification in fission yeast.

Ryuko S et al. Mol Genet Genomics 2012 Aug;287(8):651-62

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.

Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:9718372 - Evidence for a novel MAPKKK-independent pathway controlling the stress activated Sty1/Spc1 MAP kinase in fission yeast.

Shieh JC et al. J Cell Sci 1998 Sep;111 ( Pt 18):2799-807

PMID:9372444 - A zinc finger protein required for stationary phase viability in fission yeast.

Hao Z et al. J Cell Sci 1997 Oct;110 ( Pt 20):2557-66

PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.

Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895

PMID:23640764 - Phosphorylations of Sds23/Psp1/Moc1 by stress-activated kinase and cAMP-dependent kinase are essential for regulating cell viability in prolonged stationary phase.

Jang YJ et al. Yeast 2013 Oct;30(10):379-94

PMID:9321395 - Multiple modes of activation of the stress-responsive MAP kinase pathway in fission yeast.

Samejima I et al. EMBO J 1997 Oct 15;16(20):6162-70

PMID:9450957 - The Win1 mitotic regulator is a component of the fission yeast stress-activated Sty1 MAPK pathway.

Shieh JC et al. Mol Biol Cell 1998 Feb;9(2):311-22

PMID:11453251 - Factors involved in the regulation of the Schizosaccharomyces pombe malic enzyme gene.

Groenewald M et al. Curr Genet 2001 Jun;39(4):222-30

PMID:9136929 - The Mcs4 response regulator coordinately controls the stress-activated Wak1-Wis1-Sty1 MAP kinase pathway and fission yeast cell cycle.

Shieh JC et al. Genes Dev 1997 Apr 15;11(8):1008-22

PMID:8557102 - Stress signal, mediated by a Hog1-like MAP kinase, controls sexual development in fission yeast.

Kato T et al. FEBS Lett 1996 Jan 15;378(3):207-12

PMID:17881729 - Atf1 is a target of the mitogen-activated protein kinase Pmk1 and regulates cell integrity in fission yeast.

Takada H et al. Mol Biol Cell 2007 Dec;18(12):4794-802

PMID:18272791 - Activation of Srk1 by the mitogen-activated protein kinase Sty1/Spc1 precedes its dissociation from the kinase and signals its degradation.

López-Avilés S et al. Mol Biol Cell 2008 Apr;19(4):1670-9

PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.

Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:10233152 - Active nucleocytoplasmic shuttling required for function and regulation of stress-activated kinase Spc1/StyI in fission yeast.

Gaits F et al. Mol Biol Cell 1999 May;10(5):1395-407

PMID:8824588 - The Atf1 transcription factor is a target for the Sty1 stress-activated MAP kinase pathway in fission yeast.

Wilkinson MG et al. Genes Dev 1996 Sep 15;10(18):2289-301

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:21801748 - Regulation of HMG-CoA reductase in mammals and yeast.

Burg JS et al. Prog Lipid Res 2011 Oct;50(4):403-10

PMID:15135546 - Stress-dependent regulation of the gene encoding thioredoxin reductase from the fission yeast.

Hong SM et al. FEMS Microbiol Lett 2004 May 15;234(2):379-85

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:29852001 - New insights into donor directionality of mating-type switching in Schizosaccharomyces pombe.

Maki T et al. PLoS Genet 2018 May;14(5):e1007424

PMID:32554481 - Communication between Cyclin-dependent kinase Cdc2 and the Wis1-Spc1 MAPK pathway determines mitotic timing in Schizosaccharomyces pombe .

Ghosal A et al. Biol Open 2020 Jul 21;9(7)

PMID:15189983 - Suppressors of an adenylate cyclase deletion in the fission yeast Schizosaccharomyces pombe.

Stiefel J et al. Eukaryot Cell 2004 Jun;3(3):610-9

PMID:19474792 - Polar gradients of the DYRK-family kinase Pom1 couple cell length with the cell cycle.

Martin SG et al. Nature 2009 Jun 11;459(7248):852-6

PMID:23695164 - Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.

Das J et al. Sci Signal 2013 May 21;6(276):ra38

PMID:38289024 - Heat stress-induced activation of MAPK pathway attenuates Atf1-dependent epigenetic inheritance of heterochromatin in fission yeast.

Sun L et al. Elife 2024 Jan 30;13

PMID:9693384 - The fission yeast mitotic regulator win1+ encodes an MAP kinase kinase kinase that phosphorylates and activates Wis1 MAP kinase kinase in response to high osmolarity.

Samejima I et al. Mol Biol Cell 1998 Aug;9(8):2325-35

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:23389634 - Response regulator-mediated MAPKKK heteromer promotes stress signaling to the Spc1 MAPK in fission yeast.

Morigasaki S et al. Mol Biol Cell 2013 Apr;24(7):1083-92

PMID:12050156 - Surplus zinc is handled by Zym1 metallothionein and Zhf endoplasmic reticulum transporter in Schizosaccharomyces pombe.

Borrelly GP et al. J Biol Chem 2002 Aug 16;277(33):30394-400

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:7498541 - The osmo-inducible gpd1+ gene is a target of the signaling pathway involving Wis1 MAP-kinase kinase in fission yeast.

Aiba H et al. FEBS Lett 1995 Dec 04;376(3):199-201

PMID:28357272 - A central role for TOR signalling in a yeast model for juvenile CLN3 disease.

Bond ME et al. Microb Cell 2015 Nov 11;2(12):466-480

PMID:19366728 - Genetic control of cellular quiescence in S. pombe.

Sajiki K et al. J Cell Sci 2009 May 01;122(Pt 9):1418-29

PMID:7859738 - Counteractive roles of protein phosphatase 2C (PP2C) and a MAP kinase kinase homolog in the osmoregulation of fission yeast.

Shiozaki K et al. EMBO J 1995 Feb 01;14(3):492-502

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:1756736 - The wis1 protein kinase is a dosage-dependent regulator of mitosis in Schizosaccharomyces pombe.

Warbrick E et al. EMBO J 1991 Dec;10(13):4291-9

PMID:12359231 - Regulation and the role of Cu,Zn-containing superoxide dismutase in cell cycle progression of Schizosaccharomyces pombe.

Lee J et al. Biochem Biophys Res Commun 2002 Oct 04;297(4):854-62

PMID:8824587 - Conjugation, meiosis, and the osmotic stress response are regulated by Spc1 kinase through Atf1 transcription factor in fission yeast.

Shiozaki K et al. Genes Dev 1996 Sep 15;10(18):2276-88

PMID:15292231 - Regulation of Swi6/HP1-dependent heterochromatin assembly by cooperation of components of the mitogen-activated protein kinase pathway and a histone deacetylase Clr6.

Kim HS et al. J Biol Chem 2004 Oct 08;279(41):42850-9

PMID:31064814 - Proximity-dependent biotinylation mediated by TurboID to identify protein-protein interaction networks in yeast.

Larochelle M et al. J Cell Sci 2019 May 31;132(11)

PMID:34984977 - Functional profiling of long intergenic non-coding RNAs in fission yeast.

Rodriguez-Lopez M et al. Elife 2022 Jan 05;11

PMID:12080074 - The Srk1 protein kinase is a target for the Sty1 stress-activated MAPK in fission yeast.

Smith DA et al. J Biol Chem 2002 Sep 06;277(36):33411-21

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:12181336 - Cytoplasmic localization of Wis1 MAPKK by nuclear export signal is important for nuclear targeting of Spc1/Sty1 MAPK in fission yeast.

Nguyen AN et al. Mol Biol Cell 2002 Aug;13(8):2651-63

PMID:14503856 - The thioltransferase (glutaredoxin) 1 gene of fission yeast is regulated by Atf1 and Pap1.

Lim CJ et al. Mol Cells 2003 Aug 31;16(1):123-7

PMID:24255738 - Phosphorelay-dependent and -independent regulation of MAPKKK by the Mcs4 response regulator in fission yeast.

Morigasaki S et al. Commun Integr Biol 2013 Sep 01;6(5):e25020

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

PMID:8943330 - The fission yeast pmk1+ gene encodes a novel mitogen-activated protein kinase homolog which regulates cell integrity and functions coordinately with the protein kinase C pathway.

Toda T et al. Mol Cell Biol 1996 Dec;16(12):6752-64

PMID:32071154 - Fission Yeast Puf2, a Pumilio and FBF Family RNA-Binding Protein, Links Stress Granules to Processing Bodies.

Hsiao WY et al. Mol Cell Biol 2020 Apr 13;40(9)

PMID:9383051 - Mcs4, a two-component system response regulator homologue, regulates the Schizosaccharomyces pombe cell cycle control.

Cottarel G Genetics 1997 Nov;147(3):1043-51

PMID:34296454 - The TOR-dependent phosphoproteome and regulation of cellular protein synthesis.

Mak T et al. EMBO J 2021 Aug 16;40(16):e107911

PMID:19417002 - Fission yeast Tor1 functions as part of TORC1 to control mitotic entry through the stress MAPK pathway following nutrient stress.

Hartmuth S et al. J Cell Sci 2009 Jun 01;122(Pt 11):1737-46

PMID:15466417 - Regulation of leucine uptake by tor1+ in Schizosaccharomyces pombe is sensitive to rapamycin.

Weisman R et al. Genetics 2005 Feb;169(2):539-50

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:31477575 - Modulation of TOR complex 2 signaling by the stress-activated MAPK pathway in fission yeast.

Morigasaki S et al. J Cell Sci 2019 Oct 10;132(19)

PMID:18257517 - Phosphoproteome analysis of fission yeast.

Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97

PMID:25373780 - A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.

Graml V et al. Dev Cell 2014 Oct 27;31(2):227-239

PMID:37572670 - A peroxiredoxin-P38 MAPK scaffold increases MAPK activity by MAP3K-independent mechanisms.

Cao M et al. Mol Cell 2023 Sep 07;83(17):3140-3154.e7

PMID:9372449 - Onset of gluconate-H+ symport in Schizosaccharomyces pombe is regulated by the kinases Wis1 and Pka1, and requires the gti1+ gene product.

Caspari T J Cell Sci 1997 Oct;110 ( Pt 20):2599-608

PMID:10954610 - The stress-activated MAP kinase Sty1/Spc1 and a 3'-regulatory element mediate UV-induced expression of the uvi15(+) gene at the post-transcriptional level.

Kim M et al. Nucleic Acids Res 2000 Sep 01;28(17):3392-402

PMID:31932483 - A Redox-Sensitive Thiol in Wis1 Modulates the Fission Yeast Mitogen-Activated Protein Kinase Response to H 2 O 2 and Is the Target of a Small Molecule.

Sjölander JJ et al. Mol Cell Biol 2020 Mar 16;40(7)

PMID:9447985 - Novel factor highly conserved among eukaryotes controls sexual development in fission yeast.

Okazaki N et al. Mol Cell Biol 1998 Feb;18(2):887-95

PMID:11886858 - The serine/threonine kinase Cmk2 is required for oxidative stress response in fission yeast.

Sánchez-Piris M et al. J Biol Chem 2002 May 17;277(20):17722-7

PMID:9202173 - Osmo-stress-induced changes in neutral trehalase activity of the fission yeast Schizosaccharomyces pombe.

Fernández J et al. Biochim Biophys Acta 1997 Jun 05;1357(1):41-8

PMID:9843572 - The protein kinase Cdr2, related to Nim1/Cdr1 mitotic inducer, regulates the onset of mitosis in fission yeast.

Kanoh J et al. Mol Biol Cell 1998 Dec;9(12):3321-34

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:21850271 - Genome-wide screening for genes associated with FK506 sensitivity in fission yeast.

Ma Y et al. PLoS One 2011;6(8):e23422

PMID:37787465 - Glucose to lactate shift reprograms CDK-dependent mitotic decisions and its communication with MAPK Sty1 in Schizosaccharomyces pombe.

Sarkar P et al. Biol Open 2023 Oct 15;12(10)

PMID:11350071 - Characterization of the manganese-containing superoxide dismutase and its gene regulation in stress response of Schizosaccharomyces pombe.

Jeong JH et al. Biochem Biophys Res Commun 2001 May 18;283(4):908-14

PMID:16278445 - Stress-activated protein kinase pathway functions to support protein synthesis and translational adaptation in response to environmental stress in fission yeast.

Dunand-Sauthier I et al. Eukaryot Cell 2005 Nov;4(11):1785-93

PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.

Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838

PMID:9585506 - Phosphorylation and association with the transcription factor Atf1 regulate localization of Spc1/Sty1 stress-activated kinase in fission yeast.

Gaits F et al. Genes Dev 1998 May 15;12(10):1464-73

PMID:8886983 - The fission yeast sts5+ gene is required for maintenance of growth polarity and functionally interacts with protein kinase C and an osmosensing MAP-kinase pathway.

Toda T et al. J Cell Sci 1996 Sep;109 ( Pt 9):2331-42