PomBase home

protein coding gene - stn1 (SPBC409.12c) - telomere cap complex subunit Stn1

Gene summary

Standard name
stn1
Systematic ID
SPBC409.12c
Product
telomere cap complex subunit Stn1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q0E7J7
ORFeome ID
08/08A05
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 1161485..1163082 reverse strand

Annotation

Disease association

MONDO:0015026 - cerebroretinal microangiopathy with calcifications and cysts 2

References:

GO biological process

GO:0016233 - telomere capping

References:

GO:0000723 - telomere maintenance

References:

GO cellular component

GO:0140445 - chromosome, telomeric repeat region

References:

GO:1990879 - CST complex

References:

GO:0005634 - nucleus

References:

GO:0000782 - telomere cap complex

References:

GO molecular function

GO:0005515 - protein binding

References:

GO:0043047 - single-stranded telomeric DNA binding

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

Multi-locus phenotype

FYPO:0000122 - abnormal telomere maintenance during vegetative growth

References:

Genotypes:

FYPO:0002702 - circularized chromosome

References:

Genotypes:

FYPO:0000082 - decreased cell population growth at high temperature

References:

Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0002019 - elongated telomeres during vegetative growth

References:

Genotypes:

FYPO:0001387 - loss of viability at high temperature

References:

Genotypes:

FYPO:0001690 - normal growth on camptothecin

References:

Genotypes:

FYPO:0000963 - normal growth on hydroxyurea

References:

Genotypes:

FYPO:0000957 - normal growth on methyl methanesulfonate

References:

Genotypes:

FYPO:0001357 - normal vegetative cell population growth

References:

Genotypes:

FYPO:0003107 - progressively shortening telomeres during vegetative growth

References:

Genotypes:

FYPO:0005404 - telomeric regions absent from linear chromosomes

References:

Genotypes:

Protein features

PBO:0111871 - OB fold

Protein sequence feature

SO:0002235 - SUMO_interaction_motif

References:

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000059 - abnormal mitotic cell cycle

References:

Genotypes:

FYPO:0001343 - abnormal mitotic DNA replication

References:

Genotypes:

FYPO:0000122 - abnormal telomere maintenance during vegetative growth

References:

Genotypes:

FYPO:0000705 - abolished protein-protein interaction

References:

Genotypes:

FYPO:0002702 - circularized chromosome

References:

Genotypes:

FYPO:0000082 - decreased cell population growth at high temperature

References:

Genotypes:

FYPO:0003803 - decreased protein localization to telomere

References:

Genotypes:

FYPO:0001645 - decreased protein-protein interaction

References:

Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0002019 - elongated telomeres during vegetative growth

References:

Genotypes:

FYPO:0004656 - increased protein localization to telomere during vegetative growth

References:

Genotypes:

FYPO:0005402 - increased telomeric 3' overhang length during vegetative growth

References:

Genotypes:

FYPO:0003529 - inviable after spore germination, multiple cell divisions, cell cycle arrest in mitotic interphase, elongated cells

References:

Genotypes:

FYPO:0002262 - inviable after spore germination, multiple cell divisions, elongated cell

References:

Genotypes:

FYPO:0003742 - inviable after spore germination, multiple cell divisions, unequal chromosome segregation

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0001387 - loss of viability at high temperature

References:

Genotypes:

FYPO:0000703 - normal protein-protein interaction

References:

Genotypes:

FYPO:0002687 - normal telomere length during vegetative growth

References:

Genotypes:

FYPO:0001357 - normal vegetative cell population growth

References:

Genotypes:

FYPO:0000085 - sensitive to camptothecin

References:

Genotypes:

FYPO:0000266 - sensitive to DNA damaging agents

References:

Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

References:

Genotypes:

FYPO:0000089 - sensitive to methyl methanesulfonate

References:

Genotypes:

FYPO:0005404 - telomeric regions absent from linear chromosomes

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF10451Stn1Stn1_NPFAM
SSF50249Nucleic acid-binding proteinsNA-bd_OB-foldSUPERFAMILY
G3DSA:2.40.50.140NA-bd_OB-foldGENE3D

Orthologs

References / Literature

PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:17715303 - Protection of telomeres by a conserved Stn1-Ten1 complex.
Martín V et al. Proc Natl Acad Sci U S A 2007 Aug 28;104(35):14038-43
PMID:24925530 - Tpz1TPP1 SUMOylation reveals evolutionary conservation of SUMO-dependent Stn1 telomere association.
Garg M et al. EMBO Rep 2014 Aug;15(8):871-7
PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.
Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:19214192 - Differential arrival of leading and lagging strand DNA polymerases at fission yeast telomeres.
Moser BA et al. EMBO J 2009 Apr 08;28(7):810-20
PMID:19884503 - Telomere capping proteins are structurally related to RPA with an additional telomere-specific domain.
Gelinas AD et al. Proc Natl Acad Sci U S A 2009 Nov 17;106(46):19298-303
PMID:30796050 - Ssu72 phosphatase is a conserved telomere replication terminator.
Escandell JM et al. EMBO J 2019 Apr 01;38(7)
PMID:28180297 - Fission yeast Stn1 is crucial for semi-conservative replication at telomeres and subtelomeres.
Takikawa M et al. Nucleic Acids Res 2017 Feb 17;45(3):1255-1269
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:20008938 - Stn1-Ten1 is an Rpa2-Rpa3-like complex at telomeres.
Sun J et al. Genes Dev 2009 Dec 15;23(24):2900-14
PMID:12529438 - Global transcriptional responses of fission yeast to environmental stress.
Chen D et al. Mol Biol Cell 2003 Jan;14(1):214-29
PMID:24711392 - SUMOylation regulates telomere length by targeting the shelterin subunit Tpz1(Tpp1) to modulate shelterin-Stn1 interaction in fission yeast.
Miyagawa K et al. Proc Natl Acad Sci U S A 2014 Apr 22;111(16):5950-5
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:29774234 - The fission yeast Stn1-Ten1 complex limits telomerase activity via its SUMO-interacting motif and promotes telomeres replication.
Matmati S et al. Sci Adv 2018 May;4(5):eaar2740
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:30824696 - Systematic analysis reveals the prevalence and principles of bypassable gene essentiality.
Li J et al. Nat Commun 2019 Mar 01;10(1):1002