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protein coding gene - mim2 (SPBC409.23) - mitochondrial MIM complex subunit Mim2

Gene summary

Standard name
mim2
Systematic ID
SPBC409.23
Product
mitochondrial MIM complex subunit Mim2
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
tam7
UniProt ID
G2TRP0
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 1164170..1164885 forward strand

Annotation

GO biological process

GO:7770059 - alpha helical protein insertion into mitochondrial outer membrane

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GO cellular component

GO:0140595 - MIM complex

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GO:0005739 - mitochondrion

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GO molecular function

GO:0032977 - membrane insertase activity

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GO:0005515 - protein binding

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Modification

MOD:00046 - O-phospho-L-serine

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Multi-locus phenotype

FYPO:0003768 - normal protein localization to mitochondrion

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Genotypes:

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

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PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0007596 - decreased mitophagy during nitrogen starvation

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Genotypes:

FYPO:0007038 - decreased protein localization to mitochondrion

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Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0001492 - viable elongated vegetative cell

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Genotypes:

Taxonomic conservation

PBO:0011064 - conserved in fungi

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000082 - new gene

References:

Protein features

IDNameInterPro nameDB name
PF19117Mim2Mim2Pfam
PTHR28230Mim2PANTHER
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder

Orthologs

References / Literature

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:33138913 - Atg43 tethers isolation membranes to mitochondria to promote starvation-induced mitophagy in fission yeast.
Fukuda T et al. Elife 2020 Nov 03;9
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.
Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:21270388 - Augmented annotation of the Schizosaccharomyces pombe genome reveals additional genes required for growth and viability.
Bitton DA et al. Genetics 2011 Apr;187(4):1207-17
PMID:26896847 - Ensembl comparative genomics resources.
Herrero J et al. Database (Oxford) 2016;2016
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105