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protein coding gene - nup107 (SPBC428.01c) - nucleoporin Nup107

Gene summary

Standard name
nup107
Systematic ID
SPBC428.01c
Product
nucleoporin Nup107
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
SPBC582.11c
UniProt ID
Q10331
ORFeome ID
38/38H03
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 438999..442003 reverse strand

Annotation

Disease association

MONDO:0032692 - Galloway-Mowat syndrome 7

References:

MONDO:0014752 - nephrotic syndrome, type 11

References:

MONDO:0054850 - ovarian dysgenesis 6

References:

GO biological process

GO:0016973 - poly(A)+ mRNA export from nucleus

References:

GO:0000973 - post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery

References:

GO:0006606 - protein import into nucleus

References:

GO:0000054 - ribosomal subunit export from nucleus

References:

GO cellular component

GO:0005737 - cytoplasm

References:

GO:0005829 - cytosol

References:

GO:0140599 - mitotic nuclear bridge midzone membrane domain

References:

GO:0031965 - nuclear membrane

References:

GO:0034399 - nuclear periphery

References:

GO:0005643 - nuclear pore

References:

GO:0031080 - nuclear pore outer ring

References:

GO:0005634 - nucleus

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GO molecular function

GO:0017056 - structural constituent of nuclear pore

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Modification

MOD:00046 - O-phospho-L-serine

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0006926 - increased nucleus:cytoplasm ratio

References:

Genotypes:

FYPO:0004118 - inviable after spore germination, multiple cell divisions, normal septum morphology

References:

Genotypes:

FYPO:0000310 - inviable after spore germination, without cell division, with normal germ tube morphology

References:

Genotypes:

FYPO:0001490 - inviable elongated vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0002273 - inviable vegetative cell with abnormal cell morphology

References:

Genotypes:

FYPO:0003612 - viable spore population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000070 - gene structure updated

References:

Protein features

IDNameInterPro nameDB name
PF04121Nup84_Nup100Nup84/Nup107Pfam
G3DSA:1.10.3450.20:FF:000001CATH-FunFam
G3DSA:1.10.3450.20CATH-Gene3D
G3DSA:1.20.190.50CATH-Gene3D
PTHR13003Nup84/Nup107PANTHER

Orthologs

References / Literature

PMID:15226438 - The fission yeast Nup107-120 complex functionally interacts with the small GTPase Ran/Spi1 and is required for mRNA export, nuclear pore distribution, and proper cell division.
Baï SW et al. Mol Cell Biol 2004 Jul;24(14):6379-92
PMID:30759079 - A systematic genetic screen identifies essential factors involved in nuclear size control.
Cantwell H et al. PLoS Genet 2019 Feb;15(2):e1007929
PMID:12618370 - Schizosaccharomyces pombe essential genes: a pilot study.
Decottignies A et al. Genome Res 2003 Mar;13(3):399-406
PMID:15116432 - Identification of genes encoding putative nucleoporins and transport factors in the fission yeast Schizosaccharomyces pombe: a deletion analysis.
Chen XQ et al. Yeast 2004 Apr 30;21(6):495-509
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:15837798 - Efficient formation of bipolar microtubule bundles requires microtubule-bound gamma-tubulin complexes.
Janson ME et al. J Cell Biol 2005 Apr 25;169(2):297-308
PMID:24637836 - Characterization of nuclear pore complex components in fission yeast Schizosaccharomyces pombe.
Asakawa H et al. Nucleus 2014;5(2):149-62
PMID:32502403 - Selective Nuclear Pore Complex Removal Drives Nuclear Envelope Division in Fission Yeast.
Expósito-Serrano M et al. Curr Biol 2020 Aug 17;30(16):3212-3222.e2
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:30824696 - Systematic analysis reveals the prevalence and principles of bypassable gene essentiality.
Li J et al. Nat Commun 2019 Mar 01;10(1):1002
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:20970342 - Virtual breakdown of the nuclear envelope in fission yeast meiosis.
Asakawa H et al. Curr Biol 2010 Nov 09;20(21):1919-25
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83