protein coding gene - rhb1 (SPBC428.16c) - Rheb GTPase Rhb1

Gene summary

Standard name

rhb1

Systematic ID

SPBC428.16c

Product

Rheb GTPase Rhb1

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

O94363

ORFeome ID

07/07F12

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 473670..474497 reverse strand

Annotation

Protein features

Orthologs

• RHEB (HGNC:10011) Homo sapiens
• rhb1 (SJAG_02605) Schizosaccharomyces japonicus
• RHB1 (YCR027C) Saccharomyces cerevisiae

References / Literature

PMID:23813957 - The fission yeast β-arrestin-like protein Any1 is involved in TSC-Rheb signaling and the regulation of amino acid transporters.

Nakase Y et al. J Cell Sci 2013 Sep 01;126(Pt 17):3972-81

PMID:17121544 - Fission yeast Tor2 links nitrogen signals to cell proliferation and acts downstream of the Rheb GTPase.

Uritani M et al. Genes Cells 2006 Dec;11(12):1367-79

PMID:30301783 - The RHEB-mTOR axis regulates expression of Tf2 transposons in fission yeast.

Nakase Y et al. J Cell Sci 2018 Nov 21;131(22)

PMID:12869548 - Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6K.

Tabancay AP et al. J Biol Chem 2003 Oct 10;278(41):39921-30

PMID:17179073 - Opposite effects of tor1 and tor2 on nitrogen starvation responses in fission yeast.

Weisman R et al. Genetics 2007 Mar;175(3):1153-62

PMID:17360675 - Point mutations in TOR confer Rheb-independent growth in fission yeast and nutrient-independent mammalian TOR signaling in mammalian cells.

Urano J et al. Proc Natl Acad Sci U S A 2007 Feb 27;104(9):3514-9

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.

UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531

PMID:29079657 - TORC1 and TORC2 converge to regulate the SAGA co-activator in response to nutrient availability.

Laboucarié T et al. EMBO Rep 2017 Dec;18(12):2197-2218

PMID:14718525 - Tsc1+ and tsc2+ regulate arginine uptake and metabolism in Schizosaccharomyces pombe.

van Slegtenhorst M et al. J Biol Chem 2004 Mar 26;279(13):12706-13

PMID:30824696 - Systematic analysis reveals the prevalence and principles of bypassable gene essentiality.

Li J et al. Nat Commun 2019 Mar 01;10(1):1002

PMID:10835385 - Loss of Rhb1, a Rheb-related GTPase in fission yeast, causes growth arrest with a terminal phenotype similar to that caused by nitrogen starvation.

Mach KE et al. Genetics 2000 Jun;155(2):611-22

PMID:34706246 - Cross talk between the upstream exon-intron junction and Prp2 facilitates splicing of non-consensus introns.

Hümmer S et al. Cell Rep 2021 Oct 26;37(4):109893

PMID:16624901 - A defect in protein farnesylation suppresses a loss of Schizosaccharomyces pombe tsc2+, a homolog of the human gene predisposing to tuberous sclerosis complex.

Nakase Y et al. Genetics 2006 Jun;173(2):569-78

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:29199950 - Ragulator and GATOR1 complexes promote fission yeast growth by attenuating TOR complex 1 through Rag GTPases.

Chia KH et al. Elife 2017 Dec 04;6

PMID:24344203 - Isp7 is a novel regulator of amino acid uptake in the TOR signaling pathway.

Laor D et al. Mol Cell Biol 2014 Mar;34(5):794-806

PMID:12618370 - Schizosaccharomyces pombe essential genes: a pilot study.

Decottignies A et al. Genome Res 2003 Mar;13(3):399-406

PMID:16262791 - Identification of novel single amino acid changes that result in hyperactivation of the unique GTPase, Rheb, in fission yeast.

Urano J et al. Mol Microbiol 2005 Nov;58(4):1074-86

PMID:20144990 - Fission yeast TORC1 regulates phosphorylation of ribosomal S6 proteins in response to nutrients and its activity is inhibited by rapamycin.

Nakashima A et al. J Cell Sci 2010 Mar 01;123(Pt 5):777-86

PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41

PMID:18219492 - The Tsc/Rheb signaling pathway controls basic amino acid uptake via the Cat1 permease in fission yeast.

Aspuria PJ et al. Mol Genet Genomics 2008 May;279(5):441-50

PMID:28357272 - A central role for TOR signalling in a yeast model for juvenile CLN3 disease.

Bond ME et al. Microb Cell 2015 Nov 11;2(12):466-480

PMID:10617635 - Protein farnesylation is critical for maintaining normal cell morphology and canavanine resistance in Schizosaccharomyces pombe.

Yang W et al. J Biol Chem 2000 Jan 07;275(1):429-38

PMID:19620394 - Distinctive responses to nitrogen starvation in the dominant active mutants of the fission yeast Rheb GTPase.

Murai T et al. Genetics 2009 Oct;183(2):517-27

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

GO_REF:0000051 - S. pombe keyword mapping

PB_REF:0000001 - Protein modification annotation by manual transfer of experimentally-verified annotation data to orthologs based on curator judgment of sequence features.

PMID:17556368 - The Birt-Hogg-Dube and tuberous sclerosis complex homologs have opposing roles in amino acid homeostasis in Schizosaccharomyces pombe.

van Slegtenhorst M et al. J Biol Chem 2007 Aug 24;282(34):24583-90

PMID:23754748 - Splicing functions and global dependency on fission yeast slu7 reveal diversity in spliceosome assembly.

Banerjee S et al. Mol Cell Biol 2013 Aug;33(16):3125-36

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:25814783 - Conservation of the Tsc/Rheb/TORC1/S6K/S6 Signaling in Fission Yeast.

Nakashima A et al. Enzymes 2010;28:167-187

PMID:17261596 - Loss of the TOR kinase Tor2 mimics nitrogen starvation and activates the sexual development pathway in fission yeast.

Matsuo T et al. Mol Cell Biol 2007 Apr;27(8):3154-64

PMID:25639242 - Nitrogen regulates AMPK to control TORC1 signaling.

Davie E et al. Curr Biol 2015 Feb 16;25(4):445-54

PMID:16115814 - Pas1, a G1 cyclin, regulates amino acid uptake and rescues a delay in G1 arrest in Tsc1 and Tsc2 mutants in Schizosaccharomyces pombe.

van Slegtenhorst M et al. Hum Mol Genet 2005 Oct 01;14(19):2851-8