protein coding gene - cdt1 (SPBC428.18) - DNA replication licensing factor Cdt1

Gene summary

Standard name

cdt1

Systematic ID

SPBC428.18

Product

DNA replication licensing factor Cdt1

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

P40382

ORFeome ID

20/20F09

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 477392..478738 forward strand

Annotation

Protein features

Orthologs

• CDT1 (HGNC:24576) Homo sapiens
• cdt1 (SJAG_02607) Schizosaccharomyces japonicus
• TAH11 (YJR046W) Saccharomyces cerevisiae

References / Literature

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:19714215 - The fission yeast homeodomain protein Yox1p binds to MBF and confines MBF-dependent cell-cycle transcription to G1-S via negative feedback.

Aligianni S et al. PLoS Genet 2009 Aug;5(8):e1000626

PMID:20736315 - Specific replication origins promote DNA amplification in fission yeast.

Kiang L et al. J Cell Sci 2010 Sep 15;123(Pt 18):3047-51

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:31260531 - Gcn5-mediated acetylation at MBF-regulated promoters induces the G1/S transcriptional wave.

González-Medina A et al. Nucleic Acids Res 2019 Sep 19;47(16):8439-8451

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:21971174 - Abundance of prereplicative complexes (Pre-RCs) facilitates recombinational repair under replication stress in fission yeast.

Maki K et al. J Biol Chem 2011 Dec 02;286(48):41701-41710

PMID:12419251 - Stable association of mitotic cyclin B/Cdc2 to replication origins prevents endoreduplication.

Wuarin J et al. Cell 2002 Nov 01;111(3):419-31

PMID:9755169 - Cdc18 transcription and proteolysis couple S phase to passage through mitosis.

Baum B et al. EMBO J 1998 Oct 01;17(19):5689-98

PMID:16407242 - An evolutionarily conserved function of proliferating cell nuclear antigen for Cdt1 degradation by the Cul4-Ddb1 ubiquitin ligase in response to DNA damage.

Hu J et al. J Biol Chem 2006 Feb 17;281(7):3753-6

PMID:11781565 - Feedback regulation of the MBF transcription factor by cyclin Cig2.

Ayté J et al. Nat Cell Biol 2001 Dec;3(12):1043-50

PMID:25533348 - Tolerance of deregulated G1/S transcription depends on critical G1/S regulon genes to prevent catastrophic genome instability.

Caetano C et al. Cell Rep 2014 Dec 24;9(6):2279-89

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

PMID:29036220 - Defective replication initiation results in locus specific chromosome breakage and a ribosomal RNA deficiency in yeast.

Sanchez JC et al. PLoS Genet 2017 Oct;13(10):e1007041

PMID:11532929 - Expression of Cdc18/Cdc6 and Cdt1 during G2 phase induces initiation of DNA replication.

Yanow SK et al. EMBO J 2001 Sep 03;20(17):4648-56

PMID:12898217 - MCB-mediated regulation of cell cycle-specific cdc22+ transcription in fission yeast.

Maqbool Z et al. Mol Genet Genomics 2003 Sep;269(6):765-75

PMID:12618370 - Schizosaccharomyces pombe essential genes: a pilot study.

Decottignies A et al. Genome Res 2003 Mar;13(3):399-406

PMID:16899242 - Analysis of Mcm2-7 chromatin binding during anaphase and in the transition to quiescence in fission yeast.

Namdar M et al. Exp Cell Res 2006 Oct 15;312(17):3360-9

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:28903048 - Set2 Methyltransferase Facilitates DNA Replication and Promotes Genotoxic Stress Responses through MBF-Dependent Transcription.

Pai CC et al. Cell Rep 2017 Sep 12;20(11):2693-2705

PMID:8313888 - cdt1 is an essential target of the Cdc10/Sct1 transcription factor: requirement for DNA replication and inhibition of mitosis.

Hofmann JF et al. EMBO J 1994 Jan 15;13(2):425-34

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134

PMID:17039252 - DNA damage induces Cdt1 proteolysis in fission yeast through a pathway dependent on Cdt2 and Ddb1.

Ralph E et al. EMBO Rep 2006 Nov;7(11):1134-9

PMID:12604790 - The Cdc23 (Mcm10) protein is required for the phosphorylation of minichromosome maintenance complex by the Dfp1-Hsk1 kinase.

Lee JK et al. Proc Natl Acad Sci U S A 2003 Mar 04;100(5):2334-9

GO_REF:0000002 - Comments

PMID:23173672 - Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.

Pan X et al. BMC Genomics 2012 Nov 23;13:662

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:10766248 - The Cdt1 protein is required to license DNA for replication in fission yeast.

Nishitani H et al. Nature 2000 Apr 06;404(6778):625-8

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.

PMID:21493688 - Cdt1 proteolysis is promoted by dual PIP degrons and is modulated by PCNA ubiquitylation.

Guarino E et al. Nucleic Acids Res 2011 Aug;39(14):5978-90

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:14648198 - DSC1-MCB regulation of meiotic transcription in Schizosaccharomyces pombe.

Cunliffe L et al. Mol Genet Genomics 2004 Feb;271(1):60-71

PMID:17531813 - Cdc18 enforces long-term maintenance of the S phase checkpoint by anchoring the Rad3-Rad26 complex to chromatin.

Hermand D et al. Mol Cell 2007 May 25;26(4):553-63

PMID:11606752 - Redundant control of rereplication in fission yeast.

Gopalakrishnan V et al. Proc Natl Acad Sci U S A 2001 Nov 06;98(23):13114-9