protein coding gene - utp15 (SPBC428.19c) - U3 snoRNP-associated WD repeat protein Utp15

Gene summary

Standard name: utp15
Systematic ID: SPBC428.19c
Product: U3 snoRNP-associated WD repeat protein Utp15
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: O94365
ORFeome ID: 35/35C09
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome II: 478913..480918 reverse strand

Annotation

GO biological process

GO:0030490 - maturation of SSU-rRNA

References:

GO_REF:0000024

GO:0045943 - positive regulation of transcription by RNA polymerase I

References:

GO_REF:0000033

GO cellular component

GO:0005829 - cytosol

References:

PMID:16823372

GO:0072686 - mitotic spindle

References:

PMID:16823372

GO:0005730 - nucleolus

References:

PMID:16823372

GO:0032040 - small-subunit processome

References:

GO_REF:0000024

GO:0034455 - t-UTP complex

References:

GO_REF:0000024

GO molecular function

GO:0030515 - snoRNA binding

References:

GO_REF:0000024

Modification

MOD:00046 - O-phospho-L-serine

References:

PMID:25720772

Protein features

PBO:0111751 - WD repeat protein

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PMID:39367033

PomGeneEx:0000018 - protein level increased

References:

PMID:39367033

PomGeneEx:0000027 - ribosomal density decreased

References:

PMID:33313903

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0000059 - abnormal mitotic cell cycle

References:

PMID:23697806

Genotypes:

utp15delta

FYPO:0001490 - inviable elongated vegetative cell

References:

PMID:23697806

Genotypes:

utp15delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

utp15delta

FYPO:0001511 - inviable vegetative cell, abnormal cell shape, normal cell size

References:

PMID:23697806

Genotypes:

utp15delta

FYPO:0002060 - viable vegetative cell population

References:

PMID:12618370

Genotypes:

utp15delta

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

ID	Name	InterPro name	DB name
PF09384	UTP15_C	U3_snoRNA-assocProt_15_C	PFAM
PF00400	WD40	WD40_rpt	PFAM
cd00200	WD40		CDD
PS00678	WD_REPEATS_1	WD40_repeat_CS	PROSITE_PATTERNS
PS50082	WD_REPEATS_2	WD40_rpt	PROSITE_PROFILES
PS50294	WD_REPEATS_REGION		PROSITE_PROFILES
SM00320	WD40_4	WD40_rpt	SMART
PR00320	GPROTEINBRPT	WD40_PAC1	PRINTS
G3DSA:2.130.10.10:FF:001192			FUNFAM
SSF50978	WD40 repeat-like	WD40_repeat_dom_sf	SUPERFAMILY
G3DSA:2.130.10.10		WD40/YVTN_repeat-like_dom_sf	GENE3D
PTHR19924	UTP15 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 FAMILY MEMBER		PANTHER

Orthologs

UTP15 (HGNC:25758) Homo sapiens
utp15 (SJAG_02608) Schizosaccharomyces japonicus
UTP15 (YMR093W) Saccharomyces cerevisiae

References / Literature

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.: Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:21436456 - Clr4/Suv39 and RNA quality control factors cooperate to trigger RNAi and suppress antisense RNA.: Zhang K et al. Science 2011 Mar 25;331(6024):1624-7
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.: Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:12618370 - Schizosaccharomyces pombe essential genes: a pilot study.: Decottignies A et al. Genome Res 2003 Mar;13(3):399-406
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:20519959 - S. pombe genome deletion project: an update.: Spirek M et al. Cell Cycle 2010 Jun 15;9(12):2399-402
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.: Lee J et al. Nat Commun 2017 Feb 20;8:14527
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.: Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:30321377 - Proteomic profiling and functional characterization of post-translational modifications of the fission yeast RNA exosome.: Telekawa C et al. Nucleic Acids Res 2018 Nov 30;46(21):11169-11183