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protein coding gene - SPBC460.02c - translation elongation factor, glutathione S-transferase

Gene summary

Systematic ID
SPBC460.02c
Product
translation elongation factor, glutathione S-transferase
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
B5BP46
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome Chromosome II telomeric gap: 8856..9803 reverse strand

Annotation

GO biological process

GO:0002182 - cytoplasmic translational elongation

References:

GO cellular component

GO:0005737 - cytoplasm

References:

GO:0005634 - nucleus

References:

GO molecular function

GO:0004364 - glutathione transferase activity

References:

Modification

MOD:00047 - O-phospho-L-threonine

References:

MOD:01148 - ubiquitinylated lysine

References:

Protein features

PBO:0111760 - thioredoxin family

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0009041 - resistance to 2,2′-dipyridyl

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0009798 - faster evolving duplicate

Warnings

PBO:0000082 - new gene

References:

Protein features

IDNameInterPro nameDB name
PF00043GST_CGST_CPfam
PF02798GST_NGlutathione_S-Trfase_NPfam
cd03044GST_N_EF1BgammaCDD
cd03181GST_C_EF1Bgamma_likeCDD
PS50405GST_CTERGlutathione-S-Trfase_C-likePROSITE profiles
G3DSA:3.40.30.10:FF:000142CATH-FunFam
G3DSA:1.20.1050.10CATH-Gene3D
G3DSA:3.40.30.10Thioredoxin-like_sfCATH-Gene3D
SSF47616Glutathione-S-Trfase_C_sfSUPERFAMILY
SSF52833Thioredoxin-like_sfSUPERFAMILY
PTHR43986PANTHER

Orthologs

References / Literature

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:18727152 - The gap-filling sequence on the left arm of chromosome 2 in fission yeast Schizosaccharomyces pombe.
Sasaki M et al. Yeast 2008 Sep;25(9):673-9
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
GO_REF:0000116 - Automatic Gene Ontology annotation based on Rhea mapping.
PMID:26896847 - Ensembl comparative genomics resources.
Herrero J et al. Database (Oxford) 2016;2016
PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.
Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.
Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;