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protein coding gene - vba2 (SPBC460.03) - vacuolar amino acid uptake transporter

Gene summary

Standard name
vba2
Systematic ID
SPBC460.03
Product
vacuolar amino acid uptake transporter
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
B5BP47
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome Chromosome II telomeric gap: 11641..13344 forward strand

Annotation

GO biological process

GO:1990591 - asparagine transmembrane import into vacuole

References:

GO:0090518 - L-arginine transmembrane import into vacuole

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GO:0090513 - L-histidine transmembrane import into vacuole

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GO:0090517 - L-lysine transmembrane import into vacuole

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GO:0110101 - L-valine transmembrane import into vacuole

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GO cellular component

GO:0000329 - fungal-type vacuole membrane

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GO:0005774 - vacuolar membrane

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GO molecular function

GO:0015174 - basic amino acid transmembrane transporter activity

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GO:0015179 - L-amino acid transmembrane transporter activity

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Protein sequence feature

SO:0001812 - transmembrane_helix

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Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

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PomGeneEx:0000014 - RNA present

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0001592 - decreased arginine import

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Genotypes:

FYPO:0001594 - decreased asparagine import

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Genotypes:

FYPO:0001591 - decreased histidine import

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Genotypes:

FYPO:0001590 - decreased lysine import during vegetative growth

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Genotypes:

FYPO:0001593 - decreased valine import

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Genotypes:

FYPO:0009098 - increased cell population growth on mannitol carbon source

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Genotypes:

FYPO:0002758 - resistance to 4-nitroquinoline N-oxide

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Genotypes:

FYPO:0000764 - resistance to cycloheximide

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Genotypes:

FYPO:0002693 - resistance to diamide

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0002757 - resistance to quinidine

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Genotypes:

FYPO:0007933 - sensitive to 2,2′-dipyridyl

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Genotypes:

FYPO:0009067 - sensitive to amorolfine

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Genotypes:

FYPO:0000095 - sensitive to bleomycin

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Genotypes:

FYPO:0000842 - sensitive to ethanol during vegetative growth

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Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0000089 - sensitive to methyl methanesulfonate

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Genotypes:

FYPO:0003656 - sensitive to vanadate

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Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

Warnings

PBO:0000082 - new gene

References:

Protein features

IDNameInterPro nameDB name
PF07690MFS_1MFSPfam
cd17502MFS_Azr1_MDR_likeCDD
PS50850MFSMFS_domPROSITE profiles
G3DSA:1.20.1720.10:FF:000022CATH-FunFam
G3DSA:1.20.1250.20MFS_trans_sfCATH-Gene3D
G3DSA:1.20.1720.10CATH-Gene3D
SSF103473MFS_trans_sfSUPERFAMILY
PTHR23501PANTHER
Transmembrane alpha helixDeepTMHMM

Orthologs

References / Literature

PMID:24018691 - Functional expression of Schizosaccharomyces pombe Vba2p in the vacuolar membrane of Saccharomyces cerevisiae.
Pongcharoen P et al. Biosci Biotechnol Biochem 2013;77(9):1988-90
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:20944394 - Vba2p, a vacuolar membrane protein involved in basic amino acid transport in Schizosaccharomyces pombe.
Sugimoto N et al. Biosci Biotechnol Biochem 2010;74(10):2166-9
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:18727152 - The gap-filling sequence on the left arm of chromosome 2 in fission yeast Schizosaccharomyces pombe.
Sasaki M et al. Yeast 2008 Sep;25(9):673-9
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.
Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83