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protein coding gene - smg1 (SPBC4B4.05) - Sm snRNP core protein Smg1

Gene summary

Standard name
smg1
Systematic ID
SPBC4B4.05
Product
Sm snRNP core protein Smg1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O74966
ORFeome ID
02/02E05
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 3421327..3421966 forward strand

Annotation

GO biological process

GO:0000395 - mRNA 5'-splice site recognition

References:

GO:0045292 - mRNA cis splicing, via spliceosome

References:

GO cellular component

GO:0071013 - catalytic step 2 spliceosome

References:

GO:0005829 - cytosol

References:

GO:0005634 - nucleus

References:

GO:0071014 - post-mRNA release spliceosomal complex

References:

GO:0071011 - precatalytic spliceosome

References:

GO:0034719 - SMN-Sm protein complex

References:

GO:0005685 - U1 snRNP

References:

GO:0005686 - U2 snRNP

References:

GO:0071004 - U2-type prespliceosome

References:

GO:0005687 - U4 snRNP

References:

GO:0046540 - U4/U6 x U5 tri-snRNP complex

References:

GO:0005682 - U5 snRNP

References:

GO molecular function

GO:0003723 - RNA binding

References:

Modification

MOD:01148 - ubiquitinylated lysine

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000059 - abnormal mitotic cell cycle

References:

Genotypes:

FYPO:0006926 - increased nucleus:cytoplasm ratio

References:

Genotypes:

FYPO:0001490 - inviable elongated vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0001511 - inviable vegetative cell, abnormal cell shape, normal cell size

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF01423LSMSm_dom_euk/arcPfam
cd01719Sm_GSm_GCDD
PS52002SMSmPROSITE profiles
SM00651SmSm_dom_euk/arcSMART
G3DSA:2.30.30.100:FF:000019CATH-FunFam
G3DSA:2.30.30.100CATH-Gene3D
SSF50182LSM_dom_sfSUPERFAMILY
PTHR10553Lsm7/SmG-likePANTHER

Orthologs

References / Literature

PMID:25274039 - A systematic genetic screen identifies new factors influencing centromeric heterochromatin integrity in fission yeast.
Bayne EH et al. Genome Biol 2014;15(10):481
PMID:24014766 - Structural and functional characterization of the N terminus of Schizosaccharomyces pombe Cwf10.
Livesay SB et al. Eukaryot Cell 2013 Nov;12(11):1472-89
PMID:31219728 - Identification of proteins associated with splicing factors Ntr1, Ntr2, Brr2 and Gpl1 in the fission yeast Schizosaccharomyces pombe .
Cipakova I et al. Cell Cycle 2019 Jul;18(14):1532-1536
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:17264129 - Proteomic analysis of the U1 snRNP of Schizosaccharomyces pombe reveals three essential organism-specific proteins.
Newo AN et al. Nucleic Acids Res 2007;35(5):1391-401
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:24442611 - Endogenous U2·U5·U6 snRNA complexes in S. pombe are intron lariat spliceosomes.
Chen W et al. RNA 2014 Mar;20(3):308-20
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:24298023 - Characterization and in vivo functional analysis of the Schizosaccharomyces pombe ICLN gene.
Barbarossa A et al. Mol Cell Biol 2014 Feb;34(4):595-605
PMID:24713849 - Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex.
Egan ED et al. RNA 2014 Jun;20(6):867-81
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:21386897 - Systematic two-hybrid and comparative proteomic analyses reveal novel yeast pre-mRNA splicing factors connected to Prp19.
Ren L et al. PLoS One 2011 Feb 28;6(2):e16719
PMID:30759079 - A systematic genetic screen identifies essential factors involved in nuclear size control.
Cantwell H et al. PLoS Genet 2019 Feb;15(2):e1007929
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:36361590 - Defining the Functional Interactome of Spliceosome-Associated G-Patch Protein Gpl1 in the Fission Yeast Schizosaccharomyces pombe .
Selicky T et al. Int J Mol Sci 2022 Oct 24;23(21)
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:26292707 - Structure of a yeast spliceosome at 3.6-angstrom resolution.
Yan C et al. Science 2015 Sep 11;349(6253):1182-91
PMID:28947618 - Sde2 is an intron-specific pre-mRNA splicing regulator activated by ubiquitin-like processing.
Thakran P et al. EMBO J 2018 Jan 04;37(1):89-101
PMID:39833470 - Structures of aberrant spliceosome intermediates on their way to disassembly.
Soni K et al. Nat Struct Mol Biol 2025 Jan 20;
PMID:15755920 - Dim1p is required for efficient splicing and export of mRNA encoding lid1p, a component of the fission yeast anaphase-promoting complex.
Carnahan RH et al. Eukaryot Cell 2005 Mar;4(3):577-87
PMID:24874881 - The proper splicing of RNAi factors is critical for pericentric heterochromatin assembly in fission yeast.
Kallgren SP et al. PLoS Genet 2014;10(5):e1004334
PMID:41844616 - Phosphoregulation of the novel hemi-arrestin MAPK scaffold Sms1 prevents untimely mating.
Sieber B et al. Nat Commun 2026 Mar 17;