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protein coding gene - dss4 (SPBC4C3.04c) - guanyl-nucleotide exchange factor, meiosis specific

Gene summary

Standard name
dss4
Systematic ID
SPBC4C3.04c
Product
guanyl-nucleotide exchange factor, meiosis specific
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O43057
ORFeome ID
01/01D12
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 3137606..3138228 forward strand

Annotation

GO biological process

GO:0006892 - post-Golgi vesicle-mediated transport

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GO cellular component

GO:0005829 - cytosol

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GO:0016020 - membrane

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GO molecular function

GO:0005085 - guanyl-nucleotide exchange factor activity

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GO:0008270 - zinc ion binding

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Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000151 - abnormal meiotic chromosome segregation

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Genotypes:

FYPO:0006010 - abolished shmoo contact with partner cell

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Genotypes:

FYPO:0000478 - normal meiosis

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0000725 - resistance to methyl methanesulfonate

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0000022 - shmoo with long tip

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF04421Mss4Mss4Pfam
cd00246RabGEFMss4CDD
PS51796MSS4Mss4PROSITE profiles
G3DSA:2.170.150.10:FF:000005CATH-FunFam
G3DSA:2.170.150.10Mss4/transl-control_tumourCATH-Gene3D
SSF51316Mss4-like_sfSUPERFAMILY
PTHR13276Mss4PANTHER

Orthologs

References / Literature

PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.
Blyth J et al. Genetics 2018 Feb;208(2):589-603
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:16169489 - Novel genes required for meiotic chromosome segregation are identified by a high-throughput knockout screen in fission yeast.
Gregan J et al. Curr Biol 2005 Sep 20;15(18):1663-9
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721