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protein coding gene - emp43 (SPBC4F6.05c) - lectin family glycoprotein receptor Emp43

Gene summary

Standard name
emp43
Systematic ID
SPBC4F6.05c
Product
lectin family glycoprotein receptor Emp43
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
emp46
UniProt ID
O42707
ORFeome ID
18/18C04
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 2691758..2693425 reverse strand

Annotation

Disease association

MONDO:0018175 - combined deficiency of factor V and factor VIII

References:

MONDO:0009206 - factor V and factor VIII, combined deficiency of, type 1

References:

GO biological process

GO:0006888 - endoplasmic reticulum to Golgi vesicle-mediated transport

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GO cellular component

GO:0030134 - COPII-coated ER to Golgi transport vesicle

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GO:0005783 - endoplasmic reticulum

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GO:0005789 - endoplasmic reticulum membrane

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GO:0005793 - endoplasmic reticulum-Golgi intermediate compartment

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GO:0005794 - Golgi apparatus

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GO:0000139 - Golgi membrane

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GO molecular function

GO:0097020 - COPII receptor activity

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GO:0005537 - D-mannose binding

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Multi-locus phenotype

FYPO:0001367 - normal cytokinesis

References:

Genotypes:

FYPO:0005970 - normal growth on magnesium chloride

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Genotypes:

FYPO:0006836 - sensitive to magnesium chloride

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Genotypes:

Protein sequence feature

SO:0000418 - signal_peptide

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SO:0001812 - transmembrane_helix

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000443 - abnormal protein localization during vegetative growth

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Genotypes:

FYPO:0003440 - cell lysis during cytokinesis

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Genotypes:

FYPO:0000684 - decreased cell population growth on glycerol carbon source

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Genotypes:

FYPO:0002871 - decreased protein localization to growing cell tip

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Genotypes:

FYPO:0002719 - decreased protein localization to septum

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Genotypes:

FYPO:0009077 - increased cell population growth on ethanol carbon source

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Genotypes:

FYPO:0009094 - increased cell population growth on lysine and proline nitrogen source

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Genotypes:

FYPO:0009072 - increased cell population growth on lysine nitrogen source

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Genotypes:

FYPO:0000245 - loss of viability in stationary phase

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Genotypes:

FYPO:0000674 - normal cell population growth at high temperature

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Genotypes:

FYPO:0001020 - normal growth on calcium

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Genotypes:

FYPO:0000644 - normal protein localization during vegetative growth

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Genotypes:

FYPO:0001357 - normal vegetative cell population growth

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Genotypes:

FYPO:0003657 - protein mislocalized to endoplasmic reticulum during vegetative growth

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Genotypes:

FYPO:0005514 - protein mislocalized to vacuole

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Genotypes:

FYPO:0009031 - resistance to bleomycin

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Genotypes:

FYPO:0000067 - resistance to brefeldin A

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Genotypes:

FYPO:0000073 - resistance to caffeine

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Genotypes:

FYPO:0000764 - resistance to cycloheximide

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0002767 - resistance to terbinafine

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Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

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Genotypes:

FYPO:0000799 - sensitive to diamide

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Genotypes:

FYPO:0000785 - sensitive to formamide

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Genotypes:

FYPO:0001719 - sensitive to lithium

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Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0006836 - sensitive to magnesium chloride

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Genotypes:

FYPO:0009088 - sensitive to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0001214 - sensitive to potassium chloride

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Genotypes:

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0000086 - sensitive to tacrolimus

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Genotypes:

FYPO:0000115 - sensitive to valproic acid

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF03388Lectin_leg-likeLectin_legPfam
cd07308lectin_leg-likeCDD
PS51328L_LECTIN_LIKELectin_legPROSITE profiles
G3DSA:2.60.120.200CATH-Gene3D
SSF49899ConA-like_dom_sfSUPERFAMILY
PTHR12223Intracellular_Lectin-GPTPANTHER
Transmembrane alpha helixDeepTMHMM
Signal PeptideDeepTMHMM-Signal-Peptide
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder

Orthologs

References / Literature

PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:28281664 - Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.
Rallis C et al. Sci Rep 2017 Mar 10;7:44257
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.
Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.
Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:41203586 - Identification of an ERGIC-Like Compartment in Fission Yeast: Emp43 Functions as a Lectin-Like Cargo Receptor for Glycosylated Proteins.
Imamura I et al. Mol Microbiol 2025 Nov 07;
PB_REF:0000003 - Disease Association Curation
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36