PomBase home

protein coding gene - hsp78 (SPBC4F6.17c) - ATP-dependent protein disaggregase and folding chaperone Hsp78

Gene summary

Standard name
hsp78
Systematic ID
SPBC4F6.17c
Product
ATP-dependent protein disaggregase and folding chaperone Hsp78
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O74402
ORFeome ID
28/28F09
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 2723119..2725662 reverse strand

Annotation

GO biological process

GO:0042026 - protein refolding

References:

GO:0043335 - protein unfolding

References:

GO cellular component

GO:0005759 - mitochondrial matrix

References:

GO molecular function

GO:0005524 - ATP binding

References:

GO:0016887 - ATP hydrolysis activity

References:

GO:0140545 - ATP-dependent protein disaggregase activity

References:

Modification

MOD:01148 - ubiquitinylated lysine

References:

Protein features

PBO:0111792 - AAA family ATPase

Protein sequence feature

SO:0001808 - mitochondrial_targeting_signal

References:

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002111 - inviable tapered vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0112743 - yeast hsp78 and hsp104 are related to human CLBP at the C-term but have different N-terminal domains possibly due to some rearrangement in the metazoan lineage

References:

Protein features

IDNameInterPro nameDB name
PF00004AAAATPase_AAA_corePfam
PF07724AAA_2ATPase_AAA_corePfam
PF10431ClpB_D2-smallClp_ATPase_CPfam
PF17871AAA_lid_9ClpA/ClpB_AAA_lidPfam
cd00009AAACDD
cd19499RecA-like_ClpB_Hsp104-likeCDD
PS00870CLPAB_1ClpA/B_CS1PROSITE patterns
PS00871CLPAB_2ClpA/B_CS2PROSITE patterns
SM00382AAAAAA+_ATPaseSMART
SM01086ClpB_D2-smallClp_ATPase_CSMART
PR00300CLPPROTEASEAClpA/BPRINTS
G3DSA:1.10.8.60:FF:000017CATH-FunFam
G3DSA:3.40.50.300:FF:000010CATH-FunFam
G3DSA:3.40.50.300:FF:000025CATH-FunFam
G3DSA:3.40.50.300:FF:000120CATH-FunFam
G3DSA:1.10.8.60CATH-Gene3D
G3DSA:3.40.50.300P-loop_NTPaseCATH-Gene3D
SSF52540P-loop_NTPaseSUPERFAMILY
PTHR11638ClpA_ClpBPANTHER
CoilCOILS

Orthologs

References / Literature

PMID:22730331 - Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions.
Nie M et al. J Biol Chem 2012 Aug 24;287(35):29610-9
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:12529438 - Global transcriptional responses of fission yeast to environmental stress.
Chen D et al. Mol Biol Cell 2003 Jan;14(1):214-29
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:25710177 - Metabolic and chaperone gene loss marks the origin of animals: evidence for Hsp104 and Hsp78 chaperones sharing mitochondrial enzymes as clients.
Erives AJ et al. PLoS One 2015;10(2):e0117192
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:19371376 - Schizosaccharomyces pombe cell division cycle under limited glucose requires Ssp1 kinase, the putative CaMKK, and Sds23, a PP2A-related phosphatase inhibitor.
Hanyu Y et al. Genes Cells 2009 May;14(5):539-54
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
GO_REF:0000002 - Comments
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:35416247 - Tschimganine has different targets for chronological lifespan extension and growth inhibition in fission yeast.
Ohtsuka H et al. Biosci Biotechnol Biochem 2022 May 24;86(6):775-779
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.
Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895
PMID:21828039 - Mfc1 is a novel forespore membrane copper transporter in meiotic and sporulating cells.
Beaudoin J et al. J Biol Chem 2011 Sep 30;286(39):34356-72
PMID:31474649 - Identification of 15 New Bypassable Essential Genes of Fission Yeast.
Takeda A et al. Cell Struct Funct 2019 Sep 27;44(2):113-119
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623