PomBase - protein coding gene - arf1 (SPBC4F6.18c) - Arf family GTPase Arf1 - The Schizosaccharomyces pombe genome database

Protein features

ID	Name	InterPro name	DB name
PF00025	Arf	Small_GTPase_ARF/SAR	PFAM
cd04150	Arf1_5_like	Arf1-5-like	CDD
PS51417	ARF		PROSITE_PROFILES
SM00177	arf_sub_2		SMART
SM00175	rab_sub_5		SMART
SM00178	sar_sub_1	Small_GTPase_ARF/SAR	SMART
PR00328	SAR1GTPBP	Small_GTPase_ARF/SAR	PRINTS
G3DSA:3.40.50.300:FF:000554			FUNFAM
SSF52540	P-loop containing nucleoside triphosphate hydrolases	P-loop_NTPase	SUPERFAMILY
G3DSA:3.40.50.300		P-loop_NTPase	GENE3D
PTHR11711	ADP RIBOSYLATION FACTOR-RELATED	Small_GTPase_ARF	PANTHER
Coil	Coil		COILS
TIGR00231	small_GTP	Small_GTP-bd	NCBIFAM

References / Literature

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.: Halova L et al. Open Biol 2021 Apr;11(4):200405
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:34496258 - Transcription and chromatin-based surveillance mechanism controls suppression of cryptic antisense transcription.: Heo DH et al. Cell Rep 2021 Sep 07;36(10):109671
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.: UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.: Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:8212899 - Cloning and sequence of ADP-ribosylation factor 1 (ARF1) from Schizosaccharomyces pombe.: Erickson FL et al. Yeast 1993 Aug;9(8):923-7
PMID:23457617 - Haploinsufficiency of the Sec7 guanine nucleotide exchange factor gea1 impairs septation in fission yeast.: Eckler AM et al. PLoS One 2013;8(2):e56807
PMID:22730331 - Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions.: Nie M et al. J Biol Chem 2012 Aug 24;287(35):29610-9
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.: Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.: Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.: Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.: Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PB_REF:0000003 - Disease Association Curation
PMID:22540037 - Predicting the fission yeast protein interaction network.: Pancaldi V et al. G3 (Bethesda) 2012 Apr;2(4):453-67
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.: Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:23297348 - Comprehensive proteomics analysis reveals new substrates and regulators of the fission yeast clp1/cdc14 phosphatase.: Chen JS et al. Mol Cell Proteomics 2013 May;12(5):1074-86
PMID:20603077 - Dephosphorylation of F-BAR protein Cdc15 modulates its conformation and stimulates its scaffolding activity at the cell division site.: Roberts-Galbraith RH et al. Mol Cell 2010 Jul 09;39(1):86-99
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

protein coding gene - arf1 (SPBC4F6.18c) - Arf family GTPase Arf1

Gene summary

Annotation

Disease association

MONDO:0020341 - periventricular nodular heterotopia

MONDO:0032588 - periventricular nodular heterotopia 8

GO biological process

GO:0006886 - intracellular protein transport

GO:0016192 - vesicle-mediated transport

GO cellular component

GO:0005794 - Golgi apparatus

GO:0005886 - plasma membrane

GO molecular function

GO:0005525 - GTP binding

GO:0003924 - GTPase activity

Modification

MOD:00068 - N-myristoylglycine

MOD:00046 - O-phospho-L-serine

MOD:01148 - ubiquitinylated lysine

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

Quantitative gene expression

PBO:0006310 - protein level

PBO:0011963 - RNA level

Single locus phenotype

FYPO:0000311 - inviable after spore germination with normal, unseptated germ tube morphology

FYPO:0002061 - inviable vegetative cell population

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

Orthologs

References / Literature