protein coding gene - pek1 (SPBC543.07) - MAP kinase kinase Pek1

Gene summary

Standard name

pek1

Systematic ID

SPBC543.07

Product

MAP kinase kinase Pek1

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

skh1, mkk1

UniProt ID

Q9Y884

ORFeome ID

32/32E04

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 4312443..4314140 forward strand

Annotation

Protein features

Orthologs

• MAP2K1 (HGNC:6840) Homo sapiens
• MAP2K2 (HGNC:6842) Homo sapiens
• pek1 (SJAG_01181) Schizosaccharomyces japonicus
• MKK1 (YOR231W) Saccharomyces cerevisiae
• MKK2 (YPL140C) Saccharomyces cerevisiae

References / Literature

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:17881729 - Atf1 is a target of the mitogen-activated protein kinase Pmk1 and regulates cell integrity in fission yeast.

Takada H et al. Mol Biol Cell 2007 Dec;18(12):4794-802

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:25452419 - Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.

Sideri T et al. G3 (Bethesda) 2014 Dec 01;5(1):145-55

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:27451356 - Skb5, an SH3 adaptor protein, regulates Pmk1 MAPK signaling by controlling the intracellular localization of the MAPKKK Mkh1.

Kanda Y et al. J Cell Sci 2016 Aug 15;129(16):3189-202

PMID:15821139 - Systematic deletion analysis of fission yeast protein kinases.

Bimbó A et al. Eukaryot Cell 2005 Apr;4(4):799-813

PMID:39540318 - Pck2 association with the plasma membrane and efficient response of the cell integrity pathway require regulation of PI4P homeostasis by exomer.

Moscoso-Romero E et al. Open Biol 2024 Nov;14(11):240101

PMID:19264558 - Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance.

Deshpande GP et al. DNA Repair (Amst) 2009 May 01;8(5):672-9

PMID:35820914 - Antagonistic effects of mitochondrial matrix and intermembrane space proteases on yeast aging.

Vega M et al. BMC Biol 2022 Jul 12;20(1):160

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:19037094 - The Rho1p exchange factor Rgf1p signals upstream from the Pmk1 mitogen-activated protein kinase pathway in fission yeast.

Garcia P et al. Mol Biol Cell 2009 Jan;20(2):721-31

PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.

Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160

PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.

Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895

PMID:34984977 - Functional profiling of long intergenic non-coding RNAs in fission yeast.

Rodriguez-Lopez M et al. Elife 2022 Jan 05;11

PMID:23294323 - The Kin1 kinase and the calcineurin phosphatase cooperate to link actin ring assembly and septum synthesis in fission yeast.

Cadou A et al. Biol Cell 2013 Mar;105(3):129-48

PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.

UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:16291757 - Stress-induced response, localization, and regulation of the Pmk1 cell integrity pathway in Schizosaccharomyces pombe.

Madrid M et al. J Biol Chem 2006 Jan 27;281(4):2033-43

PMID:20501954 - Search for kinases related to transition of growth polarity in fission yeast.

Koyano T et al. Biosci Biotechnol Biochem 2010;74(5):1129-33

PMID:20537132 - Global fitness profiling of fission yeast deletion strains by barcode sequencing.

Han TX et al. Genome Biol 2010;11(6):R60

PMID:17005909 - Rho2 is a target of the farnesyltransferase Cpp1 and acts upstream of Pmk1 mitogen-activated protein kinase signaling in fission yeast.

Ma Y et al. Mol Biol Cell 2006 Dec;17(12):5028-37

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:10591634 - Skh1, the MEK component of the mkh1 signaling pathway in Schizosaccharomyces pombe.

Loewith R et al. J Cell Sci 2000 Jan;113 ( Pt 1):153-60

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:23738021 - A genome-wide screening of potential target genes to enhance the antifungal activity of micafungin in Schizosaccharomyces pombe.

Zhou X et al. PLoS One 2013;8(5):e65904

PMID:10365961 - The MAPK kinase Pek1 acts as a phosphorylation-dependent molecular switch.

Sugiura R et al. Nature 1999 Jun 03;399(6735):479-83

PMID:21811607 - Transient receptor potential (TRP) and Cch1-Yam8 channels play key roles in the regulation of cytoplasmic Ca2+ in fission yeast.

Ma Y et al. PLoS One 2011;6(7):e22421

PMID:33419777 - Identification of mutants with increased variation in cell size at onset of mitosis in fission yeast.

Scotchman E et al. J Cell Sci 2021 Feb 11;134(3)

PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.

Roguev A et al. Science 2008 Oct 17;322(5900):405-10

PMID:23695164 - Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.

Das J et al. Sci Signal 2013 May 21;6(276):ra38

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:27887640 - Functional and regulatory profiling of energy metabolism in fission yeast.

Malecki M et al. Genome Biol 2016 Nov 25;17(1):240

PMID:26432170 - Distinct biological activity of threonine monophosphorylated MAPK isoforms during the stress response in fission yeast.

Vázquez B et al. Cell Signal 2015 Dec;27(12):2534-42

PMID:12931193 - Feedback regulation of MAPK signalling by an RNA-binding protein.

Sugiura R et al. Nature 2003 Aug 21;424(6951):961-5

PMID:19672306 - Genome-wide screen of genes required for caffeine tolerance in fission yeast.

Calvo IA et al. PLoS One 2009 Aug 12;4(8):e6619

PMID:16928959 - Real-time monitoring of calcineurin activity in living cells: evidence for two distinct Ca2+-dependent pathways in fission yeast.

Deng L et al. Mol Biol Cell 2006 Nov;17(11):4790-800

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:32142608 - Mutations in a Single Signaling Pathway Allow Cell Growth in Heavy Water.

Kampmeyer C et al. ACS Synth Biol 2020 Apr 17;9(4):733-748

PMID:19279143 - Role of the RNA-binding protein Nrd1 and Pmk1 mitogen-activated protein kinase in the regulation of myosin mRNA stability in fission yeast.

Satoh R et al. Mol Biol Cell 2009 May;20(9):2473-85

PMID:37792890 - Elevated levels of sphingolipid MIPC in the plasma membrane disrupt the coordination of cell growth with cell wall formation in fission yeast.

Willet AH et al. PLoS Genet 2023 Oct;19(10):e1010987

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:23861937 - Genome-wide screening for genes associated with valproic acid sensitivity in fission yeast.

Zhang L et al. PLoS One 2013;8(7):e68738