protein coding gene - pim1 (SPBC557.03c) - RCC1 family Ran GEF

Gene summary

Standard name

pim1

Systematic ID

SPBC557.03c

Product

RCC1 family Ran GEF

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

dcd1, ptr2

UniProt ID

P28745

ORFeome ID

40/40G01

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 2489019..2491035 reverse strand

Annotation

Protein features

Orthologs

• RCC1 (HGNC:1913) Homo sapiens
• pim1 (SJAG_04464) Schizosaccharomyces japonicus
• SRM1 (YGL097W) Saccharomyces cerevisiae

References / Literature

PMID:17614284 - The chromatin-remodeling factor FACT contributes to centromeric heterochromatin independently of RNAi.

Lejeune E et al. Curr Biol 2007 Jul 17;17(14):1219-24

PMID:16371130 - Loss of RanGEF/Pim1 activity abolishes the orchestration of Ran-mediated mitotic cellular events in S. pombe.

Hirose E et al. Genes Cells 2006 Jan;11(1):29-46

PMID:17476213 - Alp7/TACC is a crucial target in Ran-GTPase-dependent spindle formation in fission yeast.

Sato M et al. Nature 2007 May 17;447(7142):334-7

PMID:12446769 - The Ran GTPase system in fission yeast affects microtubules and cytokinesis in cells that are competent for nucleocytoplasmic protein transport.

Salus SS et al. Mol Cell Biol 2002 Dec;22(24):8491-505

PMID:20970342 - Virtual breakdown of the nuclear envelope in fission yeast meiosis.

Asakawa H et al. Curr Biol 2010 Nov 09;20(21):1919-25

PMID:25963819 - Nucleocytoplasmic transport in the midzone membrane domain controls yeast mitotic spindle disassembly.

Lucena R et al. J Cell Biol 2015 May 11;209(3):387-402

PMID:12181330 - Crp79p, like Mex67p, is an auxiliary mRNA export factor in Schizosaccharomyces pombe.

Thakurta AG et al. Mol Biol Cell 2002 Aug;13(8):2571-84

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:12376568 - An evolutionarily conserved fission yeast protein, Ned1, implicated in normal nuclear morphology and chromosome stability, interacts with Dis3, Pim1/RCC1 and an essential nucleoporin.

Tange Y et al. J Cell Sci 2002 Nov 15;115(Pt 22):4375-85

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134

PMID:7687541 - Regulation of RNA processing and transport by a nuclear guanine nucleotide release protein and members of the Ras superfamily.

Kadowaki T et al. EMBO J 1993 Jul;12(7):2929-37

PMID:11927555 - The fission yeast NIMA kinase Fin1p is required for spindle function and nuclear envelope integrity.

Krien MJ et al. EMBO J 2002 Apr 02;21(7):1713-22

PMID:7877997 - A mutation in the RCC1-related protein pim1 results in nuclear envelope fragmentation in fission yeast.

Demeter J et al. Proc Natl Acad Sci U S A 1995 Feb 28;92(5):1436-40

PMID:7987414 - Phenotype of the fission yeast cell cycle regulatory mutant pim1-46 is suppressed by a tobacco cDNA encoding a small, Ran-like GTP-binding protein.

Merkle T et al. Plant J 1994 Oct;6(4):555-65

PMID:8016079 - A small nuclear GTP-binding protein from tomato suppresses a Schizosaccharomyces pombe cell-cycle mutant.

Ach RA et al. Proc Natl Acad Sci U S A 1994 Jun 21;91(13):5863-7

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:8313905 - A fission yeast RCC1-related protein is required for the mitosis to interphase transition.

Sazer S et al. EMBO J 1994 Feb 01;13(3):606-15

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:9168469 - Isolation and molecular characterization of mRNA transport mutants in Schizosaccharomyces pombe.

Azad AK et al. Mol Biol Cell 1997 May;8(5):825-41

PMID:31474649 - Identification of 15 New Bypassable Essential Genes of Fission Yeast.

Takeda A et al. Cell Struct Funct 2019 Sep 27;44(2):113-119

PMID:9560394 - Isolation and characterization of fission yeast sns mutants defective at the mitosis-to-interphase transition.

Matynia A et al. Genetics 1998 Apr;148(4):1799-811

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:9786952 - imp2, a new component of the actin ring in the fission yeast Schizosaccharomyces pombe.

Demeter J et al. J Cell Biol 1998 Oct 19;143(2):415-27

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:19571115 - Nuclear shape, growth and integrity in the closed mitosis of fission yeast depend on the Ran-GTPase system, the spindle pole body and the endoplasmic reticulum.

Gonzalez Y et al. J Cell Sci 2009 Jul 15;122(Pt 14):2464-72

PMID:22540024 - Fission yeast Lem2 and Man1 perform fundamental functions of the animal cell nuclear lamina.

Gonzalez Y et al. Nucleus 2012;3(1):60-76

PMID:10233152 - Active nucleocytoplasmic shuttling required for function and regulation of stress-activated kinase Spc1/StyI in fission yeast.

Gaits F et al. Mol Biol Cell 1999 May;10(5):1395-407

PMID:17579515 - The spindle pole bodies facilitate nuclear envelope division during closed mitosis in fission yeast.

Zheng L et al. PLoS Biol 2007 Jul;5(7):e170

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:8387358 - Interaction of the pim1/spi1 mitotic checkpoint with a protein phosphatase.

Matsumoto T et al. Mol Biol Cell 1993 Mar;4(3):337-45

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:18422602 - Schizosaccharomyces pombe Snf2SR, a novel SNF2 family protein, interacts with Ran GTPase and modulates both RanGEF and RanGAP activities.

Ohba T et al. Genes Cells 2008 Jun;13(6):571-82

PMID:9504913 - The identification of cDNAs that affect the mitosis-to-interphase transition in Schizosaccharomyces pombe, including sbp1, which encodes a spi1p-GTP-binding protein.

He X et al. Genetics 1998 Feb;148(2):645-56

PMID:8896453 - Dis3, implicated in mitotic control, binds directly to Ran and enhances the GEF activity of RCC1.

Noguchi E et al. EMBO J 1996 Oct 15;15(20):5595-605

PMID:21324894 - Nuclear protein quality is regulated by the ubiquitin-proteasome system through the activity of Ubc4 and San1 in fission yeast.

Matsuo Y et al. J Biol Chem 2011 Apr 15;286(15):13775-90

PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.

Køhler JB et al. Nat Commun 2015 Nov 05;6:8827

PMID:9490640 - A NIMA homologue promotes chromatin condensation in fission yeast.

Krien MJ et al. J Cell Sci 1998 Apr;111 ( Pt 7):967-76

PMID:9585505 - Regulation of the fission yeast transcription factor Pap1 by oxidative stress: requirement for the nuclear export factor Crm1 (Exportin) and the stress-activated MAP kinase Sty1/Spc1.

Toone WM et al. Genes Dev 1998 May 15;12(10):1453-63

PMID:19111658 - HP1 proteins form distinct complexes and mediate heterochromatic gene silencing by nonoverlapping mechanisms.

Motamedi MR et al. Mol Cell 2008 Dec 26;32(6):778-90

PMID:15548596 - Analysis of mutant phenotypes and splicing defects demonstrates functional collaboration between the large and small subunits of the essential splicing factor U2AF in vivo.

Webb CJ et al. Mol Biol Cell 2005 Feb;16(2):584-96

PMID:31883795 - Positioning Heterochromatin at the Nuclear Periphery Suppresses Histone Turnover to Promote Epigenetic Inheritance.

Holla S et al. Cell 2020 Jan 09;180(1):150-164.e15

PMID:1855255 - Premature initiation of mitosis in yeast lacking RCC1 or an interacting GTPase.

Matsumoto T et al. Cell 1991 Jul 26;66(2):347-60

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.

Mata J et al. Nat Genet 2002 Sep;32(1):143-7

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:11086011 - The fission yeast ran GTPase is required for microtubule integrity.

Fleig U et al. J Cell Biol 2000 Nov 27;151(5):1101-11

PMID:19443688 - Diverse roles of HP1 proteins in heterochromatin assembly and functions in fission yeast.

Fischer T et al. Proc Natl Acad Sci U S A 2009 Jun 02;106(22):8998-9003

PMID:21340088 - Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.

Arita Y et al. Mol Biosyst 2011 May;7(5):1463-72

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:8887664 - Perturbations in the spi1p GTPase cycle of Schizosaccharomyces pombe through its GTPase-activating protein and guanine nucleotide exchange factor components result in similar phenotypic consequences.

Matynia A et al. Mol Cell Biol 1996 Nov;16(11):6352-62

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623