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protein coding gene - SPBC56F2.07c - ribosome biogenesis factor recycling AAA family ATPase

Gene summary

Systematic ID
SPBC56F2.07c
Product
ribosome biogenesis factor recycling AAA family ATPase
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O60058
ORFeome ID
28/28G02
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 4100538..4103224 forward strand

Annotation

Disease association

MONDO:0014698 - microcephaly-intellectual disability-sensorineural hearing loss-epilepsy-abnormal muscle tone syndrome

References:

GO biological process

GO:0042273 - ribosomal large subunit biogenesis

References:

GO cellular component

GO:0005829 - cytosol

References:

GO molecular function

GO:0005524 - ATP binding

References:

GO:0016887 - ATP hydrolysis activity

References:

Protein features

PBO:0111792 - AAA family ATPase

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000311 - inviable after spore germination with normal, unseptated germ tube morphology

References:

Genotypes:

FYPO:0002151 - inviable spore

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00004AAAATPase_AAA_corePfam
PF17862AAA_lid_3AAA_lid_3Pfam
cd19503RecA-like_CDC48_NLV2_r1-likeCDD
cd19511RecA-like_CDC48_r2-likeCDD
PS00674AAAATPase_AAA_CSPROSITE patterns
SM00382AAAAAA+_ATPaseSMART
G3DSA:1.10.8.60:FF:000069CATH-FunFam
G3DSA:1.10.8.60:FF:000071CATH-FunFam
G3DSA:3.40.50.300:FF:000012CATH-FunFam
G3DSA:3.40.50.300:FF:000018CATH-FunFam
G3DSA:1.10.8.60CATH-Gene3D
G3DSA:3.40.50.300P-loop_NTPaseCATH-Gene3D
SSF52540P-loop_NTPaseSUPERFAMILY
PTHR23077AAA_ATPase_domainPANTHER
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder
mobidb-lite-Low-complexitydisorder_predictionMobiDB-Low-complexity

Orthologs

References / Literature

GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:23695164 - Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.
Das J et al. Sci Signal 2013 May 21;6(276):ra38
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
GO_REF:0000002 - Comments
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6