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protein coding gene - rec27 (SPBC577.05c) - meiotic recombination protein Rec27

Gene summary

Standard name
rec27
Systematic ID
SPBC577.05c
Product
meiotic recombination protein Rec27
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
mug41
UniProt ID
Q9USR4
ORFeome ID
42/42E10
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 757399..758042 reverse strand

Annotation

GO biological process

GO:0010780 - meiotic DNA double-strand break formation involved in reciprocal meiotic recombination

References:

GO:0007131 - reciprocal meiotic recombination

References:

GO cellular component

GO:0000785 - chromatin

References:

GO:0005829 - cytosol

References:

GO:0030998 - linear element

References:

GO:0005634 - nucleus

References:

GO molecular function

GO:0031490 - chromatin DNA binding

References:

Multi-locus phenotype

FYPO:0002485 - decreased intergenic meiotic recombination

References:

Genotypes:

FYPO:0003179 - decreased intragenic meiotic recombination

References:

Genotypes:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PomGeneEx:0000018 - protein level increased

References:

PomGeneEx:0000021 - protein present

References:

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0004585 - abnormal linear element morphology

References:

Genotypes:

FYPO:0000909 - abnormal protein localization to linear element

References:

Genotypes:

FYPO:0003066 - abnormal sporulation resulting in formation of ascus with fewer than four spores

References:

Genotypes:

FYPO:0003181 - abolished meiotic DNA double-strand break formation

References:

Genotypes:

FYPO:0006161 - abolished protein localization to chromatin during meiosis I

References:

Genotypes:

FYPO:0003743 - decreased cell population growth during glucose starvation

References:

Genotypes:

FYPO:0002485 - decreased intergenic meiotic recombination

References:

Genotypes:

FYPO:0003179 - decreased intragenic meiotic recombination

References:

Genotypes:

FYPO:0003615 - decreased meiotic DNA double-strand break formation

References:

Genotypes:

FYPO:0004058 - decreased meiotic recombination at CRE promoter

References:

Genotypes:

FYPO:0003540 - decreased regional homologous chromosome pairing

References:

Genotypes:

FYPO:0004665 - linear elements absent from cell

References:

Genotypes:

FYPO:0003891 - normal intragenic meiotic recombination

References:

Genotypes:

FYPO:0004606 - normal protein level during meiotic cell cycle

References:

Genotypes:

FYPO:0006162 - normal protein localization to chromatin during meiosis I

References:

Genotypes:

FYPO:0003538 - premature meiosis I

References:

Genotypes:

FYPO:0009035 - resistance to formamide

References:

Genotypes:

FYPO:0000830 - resistance to vanadate

References:

Genotypes:

FYPO:0000799 - sensitive to diamide

References:

Genotypes:

FYPO:0007931 - sensitive to egtazic acid

References:

Genotypes:

FYPO:0009071 - sensitive to itraconazole

References:

Genotypes:

FYPO:0001719 - sensitive to lithium

References:

Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0016885 - Schizosaccharomyces specific

Warnings

PBO:0000070 - gene structure updated

References:

Protein features

IDNameInterPro nameDB name
CoilCoilCOILS

Orthologs

References / Literature

PMID:25579976 - Phosphorylation of cohesin Rec11/SA3 by casein kinase 1 promotes homologous recombination by assembling the meiotic chromosome axis.
Sakuno T et al. Dev Cell 2015 Jan 26;32(2):220-30
PMID:23395004 - Protein determinants of meiotic DNA break hot spots.
Fowler KR et al. Mol Cell 2013 Mar 07;49(5):983-96
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:19756689 - SUMOylation is required for normal development of linear elements and wild-type meiotic recombination in Schizosaccharomyces pombe.
Spirek M et al. Chromosoma 2010 Feb;119(1):59-72
PMID:16303567 - A large-scale screen in S. pombe identifies seven novel genes required for critical meiotic events.
Martín-Castellanos C et al. Curr Biol 2005 Nov 22;15(22):2056-62
PMID:16615890 - Meiotic proteins bqt1 and bqt2 tether telomeres to form the bouquet arrangement of chromosomes.
Chikashige Y et al. Cell 2006 Apr 07;125(1):59-69
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.
Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
PMID:28281664 - Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.
Rallis C et al. Sci Rep 2017 Mar 10;7:44257
PMID:18514516 - Rec25 and Rec27, novel linear-element components, link cohesin to meiotic DNA breakage and recombination.
Davis L et al. Curr Biol 2008 Jun 03;18(11):849-54
PMID:28469148 - Functional organization of protein determinants of meiotic DNA break hotspots.
Ma L et al. Sci Rep 2017 May 03;7(1):1393
PMID:30640914 - CDK contribution to DSB formation and recombination in fission yeast meiosis.
Bustamante-Jaramillo LF et al. PLoS Genet 2019 Jan;15(1):e1007876
PMID:33526714 - Activation of meiotic recombination by nuclear import of the DNA break hotspot-determining complex in fission yeast.
Wintrebert M et al. J Cell Sci 2021 Feb 22;134(4)
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:33825974 - Linear elements are stable structures along the chromosome axis in fission yeast meiosis.
Ding DQ et al. Chromosoma 2021 Sep;130(2-3):149-162
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:26670050 - Regulation of mRNA Levels by Decay-Promoting Introns that Recruit the Exosome Specificity Factor Mmi1.
Kilchert C et al. Cell Rep 2015 Dec 22;13(11):2504-2515
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:25993311 - Casein Kinase 1 and Phosphorylation of Cohesin Subunit Rec11 (SA3) Promote Meiotic Recombination through Linear Element Formation.
Phadnis N et al. PLoS Genet 2015 May;11(5):e1005225
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:30217891 - Physical basis for long-distance communication along meiotic chromosomes.
Fowler KR et al. Proc Natl Acad Sci U S A 2018 Oct 02;115(40):E9333-E9342
PMID:33574613 - TOR targets an RNA processing network to regulate facultative heterochromatin, developmental gene expression and cell proliferation.
Wei Y et al. Nat Cell Biol 2021 Mar;23(3):243-256
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12