protein coding gene - ubp10 (SPBC577.07) - ubiquitin C-terminal hydrolase Ubp10

Gene summary

Standard name: ubp10
Systematic ID: SPBC577.07
Product: ubiquitin C-terminal hydrolase Ubp10
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: Q9USR2
ORFeome ID: 34/34G07
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome II: 764512..766395 forward strand

Annotation

GO biological process

GO:0000245 - spliceosomal complex assembly

References:

GO_REF:0000033

GO cellular component

GO:0005634 - nucleus

References:

PMID:16823372

GO:0046540 - U4/U6 x U5 tri-snRNP complex

References:

GO_REF:0000024

GO molecular function

GO:0004843 - cysteine-type deubiquitinase activity

References:

GO_REF:0000002

GO:0008270 - zinc ion binding

References:

GO_REF:0000002

Protein features

PBO:0111784 - zf-UBP type

PBO:0111743 - zinc finger protein

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PMID:39367033

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0001490 - inviable elongated vegetative cell

References:

PMID:23697806

Genotypes:

ubp10delta

FYPO:0001489 - inviable vegetative cell

References:

PMID:23697806

Genotypes:

ubp10delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

ubp10delta

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

ID	Name	InterPro name	DB name
PF02148	zf-UBP	Znf_UBP	PFAM
PF00443	UCH	Peptidase_C19_UCH	PFAM
cd02669	Peptidase_C19M	USP39	CDD
PS50235	USP_3	USP	PROSITE_PROFILES
PS50271	ZF_UBP	Znf_UBP	PROSITE_PROFILES
SM00290	Zf_UBP_1	Znf_UBP	SMART
G3DSA:3.30.40.10:FF:000068			FUNFAM
SSF57850	RING/U-box		SUPERFAMILY
SSF54001	Cysteine proteinases	Papain-like_cys_pep_sf	SUPERFAMILY
G3DSA:3.90.70.10	Cysteine proteinases		GENE3D
G3DSA:3.30.40.10	Zinc/RING finger domain, C3HC4 (zinc finger)	Znf_RING/FYVE/PHD	GENE3D
PTHR21646	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE	Ub_carboxyl-term_hydrolase	PANTHER

Orthologs

USP39 (HGNC:20071) Homo sapiens
ubp10 (SJAG_04538) Schizosaccharomyces japonicus
SAD1 (YFR005C) Saccharomyces cerevisiae

References / Literature

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
GO_REF:0000002 - Comments
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.: Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.: Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7
GO_REF:0000033 - Annotation inferences using phylogenetic trees
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:28446597 - The histone variant H2A.Z promotes splicing of weak introns.: Nissen KE et al. Genes Dev 2017 Apr 01;31(7):688-701
PMID:30355493 - Expanded Interactome of the Intrinsically Disordered Protein Dss1.: Schenstrøm SM et al. Cell Rep 2018 Oct 23;25(4):862-870
PMID:29464330 - The interplay of histone H2B ubiquitination with budding and fission yeast heterochromatin.: Zukowski A et al. Curr Genet 2018 Aug;64(4):799-806
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:30824696 - Systematic analysis reveals the prevalence and principles of bypassable gene essentiality.: Li J et al. Nat Commun 2019 Mar 01;10(1):1002
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36